Abstract：
:This work aimed to clarify the relationship between polymer function and insulin absorption, and to evaluate the optimized preparative formulation predicted from this relationship. Insulin-loaded polymer (ILP) carrier systems were prepared following a two-factor composite second-order spherical experimental design. To investigate the polymer function, we evaluated its insulin release, bioadhesiveness, and protective effect. Each ILP was administered intestinally, and glucose reduction was monitored as the pharmacological effect. Based on these data, an optimized formulation was predicted and how the polymer function affects insulin absorption was clarified by multivariate spline (MVS) interpolation. A greater pharmacological effect was apparent in ILPs with a smaller particle size and loaded with more insulin. The pharmacological effect predicted by MVS after the administration of ILP made under optimized preparative conditions was almost identical to the observed effect. Moreover, MVS clarified the relationship between the polymer function and the pharmacological effect. These results supported that MVS can be an effective tool with which to approximate the relationship between the function of a dosage form and its absorption, and to explore the optimized preparative conditions.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Nakamura K,Morishita M,Ehara J,Onuki Y,Yamagata T,Kamei N,Lowman AM,Peppas NA,Takayma Kdoi
10.1016/j.ijpharm.2007.10.050subject
Has Abstractpub_date
2008-04-16 00:00:00pages
135-42issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(07)00872-1journal_volume
354pub_type
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