Abstract：
:In this note we describe the substitution of the phospholipid component in classical ISCOMs (immune-stimulating complexes) with the cationic lipid dioleoyl-trimethyl-ammonium-propane (DOTAP). The self-assembled colloidal structures formed by DOTAP, Quil-A and cholesterol were characterised using transmission electron microscopy and laser Doppler velocimetry. Samples were prepared using the lipid-film hydration and dialysis techniques. Cage-like structures containing DOTAP were obtained in high numbers using dialysis, but not lipid-film hydration on day 4 post-preparation. The formation of cage-like structures was however only observed at compositions with low weight proportions of DOTAP (less than 25%) resulting in neutral to negative zeta-potentials of the colloidal particles. Compositions with high weight proportions of DOTAP displayed phase separation phenomena. Thus, whilst DOTAP can be incorporated with Quil-A and cholesterol to form cage-like particles, it appears to be unsuitable to prepare cationic equivalents of ISCOMs.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Lendemans DG,Egert AM,Hook S,Rades Tdoi
10.1016/j.ijpharm.2006.09.029subject
Has Abstractpub_date
2007-03-06 00:00:00pages
192-5issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(06)00780-0journal_volume
332pub_type
杂志文章abstract：:Many medicines prescribed for children are unlicensed. Solid dosage forms present problems as children have difficulty swallowing whole tablets or capsules. When medicines are not licensed for children, it is unlikely that there will be a suitable, licensed liquid formulation and so extemporaneous liquid preparations ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2005.05.006
更新日期：2005-08-26 00:00:00
abstract：:Floating (F) microcapsules containing melatonin (MT) were prepared by the ionic interaction of chitosan and a negatively charged surfactant, sodium dioctyl sulfosuccinate (DOS). The DOS/chitosan complex formation was confirmed employing infrared spectroscopy, differential scanning calorimetry (DSC), solubility and X-r...
journal_title：International journal of pharmaceutics
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doi：10.1016/s0378-5173(02)00396-4
更新日期：2002-12-05 00:00:00
abstract：:Niacinamide-containing moisturisers are known be efficacious in alleviating dry skin conditions and improving stratum corneum (SC) barrier function. However, the mechanisms of action of niacinamide at the molecular level in the SC are still not well understood. Previously, we have reported the development of novel met...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章,随机对照试验
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更新日期：2013-01-30 00:00:00
abstract：:Amphotericin B (AmB) is a wide spectrum antifungal with low incidence of clinical resistance. However, there are no licensed topical formulations with AmB in most developed countries. Extemporaneous preparations of AmB are frequently prepared from available marketed parenteral formulations. Herein, a solution of AmB w...
journal_title：International journal of pharmaceutics
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doi：10.1016/j.ijpharm.2012.07.065
更新日期：2012-11-01 00:00:00
abstract：:Development of an oral docetaxel formulation has been hindered mainly due to its poor solubility and oral bioavailability. The aim of this study was to develop poloxamer F68/P85-based solid dispersions (SDs) for the oral delivery of docetaxel and investigate their in vivo pharmacokinetic impacts on the systemic absorp...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2016.05.002
更新日期：2016-06-30 00:00:00
abstract：:A simple in vitro method for the detection of precipitation using 96-well microplates and a SpectraMax Plus microtiter plate reader has been developed and described. The method requires only small amount of drug and is, therefore, potentially applicable in early pre-formulation. The method is based on opacity changes ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2005.08.012
更新日期：2005-11-04 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2004.05.025
更新日期：2004-08-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2018.06.039
更新日期：2018-08-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2008-01-22 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2009.05.017
更新日期：2009-07-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2015-11-10 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2006.11.052
更新日期：2007-05-04 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2003.11.027
更新日期：2004-03-01 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2020-11-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2003.10.040
更新日期：2004-06-11 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/s0378-5173(02)00009-1
更新日期：2002-04-02 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2013.07.079
更新日期：2013-11-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2019-07-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2000-03-20 00:00:00
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更新日期：2008-11-03 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2015-05-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2010-08-16 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2021-01-05 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2006-01-03 00:00:00
abstract：:As none of the pharmacopoeial dissolution methods are suitable to evaluate the release rate of artemether and dihydroartemisinin from tablets, a 'two-phase partition-dissolution' method, based on the one of [J. Pharm. Sci. 85 (1996) 1060] was developed. It consists of an organic solvent in the upper part and the aqueo...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2004-04-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2008.01.060
更新日期：2008-06-05 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2008-11-19 00:00:00
abstract：:The high incidence of degenerative tears and prevalence of retears (20-95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
doi：10.1016/j.ijpharm.2018.01.006
更新日期：2018-06-15 00:00:00
abstract：:Cascade impactor analysis is the standard technique for in vitro characterization of aerosol clouds generated by medical aerosol generators. One important reason for using this inertial separation principle is that drug fractions are classified into aerodynamic size ranges that are relevant to the deposition in the re...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2002-12-05 00:00:00
