Biodegradable microparticulate system of captopril.


:Albumin microparticles have found many applications in diagnosis and treatment in recent years and more than 100 diagnostic agents and drugs have been incorporated into albumin microparticles. In the present study, bovine serum albumin (BSA) based microparticles bearing captopril were prepared by an emulsification-heat stabilization technique. Four batches of microparticles with varying ratio of drug and polymer were prepared. The prepared microparticles were studied for drug loading, particle size distribution, in vitro release characteristics, in vivo tissue distribution study and stability studies. The microparticles had mean diameter between 2 and 11 microm of which more than 70% were below 5 microm and incorporation efficiency of 41-63% was obtained. In vitro release profile for formulations containing captopril-loaded albumin microparticles with heat stabilizing technique shows slow controlled release up to 24 h. The in vivo result of drug-loaded microparticles showed preferential drug targeting to liver followed by lungs, kidneys and spleen. Stability studies showed that maximum drug content and closest in vitro release to initial data were found in the formulation stored at 4 degrees C. In the present study, captopril-loaded BSA microparticles were prepared and targeted to various organs to a satisfactory level and were found to be stable at 4 degrees C.


Int J Pharm


Dandagi PM,Mastiholimath VS,Patil MB,Gupta MK





Has Abstract


2006-01-03 00:00:00














  • Development of novel diolein-niosomes for cutaneous delivery of tretinoin: influence of formulation and in vitro assessment.

    abstract:UNLABELLED:This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol(®), as carriers for cutaneous drug delivery. The model drug was tretinoin and conventional, and Labrasol(®) containing liposomes was used as controls to evaluate the influen...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Manca ML,Manconi M,Nacher A,Carbone C,Valenti D,Maccioni AM,Sinico C,Fadda AM

    更新日期:2014-12-30 00:00:00

  • Effect of granule properties on rough mouth feel and palatability of orally disintegrating tablets.

    abstract::In this study, we evaluated the palatability of orally disintegrating tablets (ODTs) containing core granules with different particle sizes, coating, and types of materials using visual analog scales (VAS). Tableting the core granules into ODTs reduced rough mouth feel and improved overall palatability compared to the...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,随机对照试验


    authors: Kimura S,Uchida S,Kanada K,Namiki N

    更新日期:2015-04-30 00:00:00

  • 3D printed medicines: A new branch of digital healthcare.

    abstract::Three-dimensional printing (3DP) is a highly disruptive technology with the potential to change the way pharmaceuticals are designed, prescribed and produced. Owing to its low cost, diversity, portability and simplicity, fused deposition modeling (FDM) is well suited to a multitude of pharmaceutical applications in di...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Awad A,Trenfield SJ,Gaisford S,Basit AW

    更新日期:2018-09-05 00:00:00

  • Novel methods of drug administration for the treatment and care of older patients.

    abstract::The number of older people globally is increasing, contributing to a growing burden of morbidity and mortality. With this shift in population demographic, comes a new challenge in terms of appropriate healthcare for the over 65 years age group. As medication is the principal therapeutic intervention, it is essential t...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Quinn HL,Hughes CM,Donnelly RF

    更新日期:2016-10-30 00:00:00

  • Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.

    abstract::Nanoparticles delivery of oligonucleotides represents a potential approach for cancer treatment. However, most of the experiments were based on established cancer cell lines and may not reflect the original solid tumor in vivo. Both, tumor microenvironment and tumor cell biological properties in the tumor can influenc...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Dong M,Philippi C,Loretz B,Nafee N,Schaefer UF,Friedel G,Ammon-Treiber S,Griese EU,Lehr CM,Klotz U,Mürdter TE

    更新日期:2011-10-31 00:00:00

  • Gelatin-based membrane containing usnic acid-loaded liposome improves dermal burn healing in a porcine model.

    abstract::There are a range of products available which claim to accelerate the healing of burns; these include topical agents, interactive dressings and biomembranes. The aim of this study was to assess the effect of a gelatin-based membrane containing usnic acid/liposomes on the healing of burns in comparison to silver sulfad...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nunes PS,Rabelo AS,Souza JC,Santana BV,da Silva TM,Serafini MR,Dos Passos Menezes P,Dos Santos Lima B,Cardoso JC,Alves JC,Frank LA,Guterres SS,Pohlmann AR,Pinheiro MS,de Albuquerque RL Júnior,Araújo AA

    更新日期:2016-11-20 00:00:00

  • The degradation of N,N',N"-triethylenephosphoramide in aqueous solutions: a qualitative and kinetic study.

    abstract::The degradation of N,N',N"-triethylenephosphoramide (TEPA) in aqueous solutions has been investigated over a pH range of 3-14. Samples were analyzed using a gas chromatographic system with nitrogen/phosphorus selective detection. The degradation kinetics were studied as function of pH, sodium chloride concentration an...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: van Maanen RJ,Tijhof IM,Damen JM,Zwikker JW,Beijnen JH

    更新日期:2000-02-25 00:00:00

  • MiRNA-204-5p and oxaliplatin-loaded silica nanoparticles for enhanced tumor suppression effect in CD44-overexpressed colon adenocarcinoma.

    abstract::Main purpose of present study was to enhance the therapeutic efficacy in the treatment of colon adenocarcinoma by combining the benefits of chemotherapy and gene therapy. In this study, we have successfully formulated oxaliplatin (OXL) and miRNA-204-5p loaded polyethyleneimine (PEI)/hyaluronic acid (HA)-assembled meso...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Yang H,Liu Y,Qiu Y,Ding M,Zhang Y

    更新日期:2019-07-20 00:00:00

  • Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery.

    abstract::Emulsion technology has been utilized extensively in the pharmaceutical industry. This article presents a comprehensive review of the literature on an important subcategory of emulsions, microemulsions. Microemulsions are optically transparent, thermodynamically stable colloidal systems, 10-100nm diameter, that form s...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Callender SP,Mathews JA,Kobernyk K,Wettig SD

    更新日期:2017-06-30 00:00:00

  • A preliminary study for the development and optimization by experimental design of an in vitro method for prediction of drug buccal absorption.

    abstract::The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation coefficient (Papp) through excised porci...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Mura P,Orlandini S,Cirri M,Maestrelli F,Mennini N,Casella G,Furlanetto S

    更新日期:2018-08-25 00:00:00

  • Blending of agglomerates into powders 1: Quantification of abrasion rate.

    abstract::A very common situation in the pharmaceutical arena is that a small amount of cohesive drug substance needs to be distributed in a large bulk of free-flowing filler such as lactose. The key topic of attention is that aggregates of a cohesive drug substance need to be sufficiently broken up in an acceptable time-frame....

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Willemsz TA,Oostra W,Hooijmaijers R,de Vegt O,Morad N,Vromans H,Frijlink HW,Van der Voort Maarschalk K

    更新日期:2010-03-15 00:00:00

  • Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan capsules.

    abstract::In general, absorption enhancing effects of various absorption enhancers were greater in the large intestine than those in the small intestinal regions. Therefore, the effectiveness of absorption enhancers is expected to be remarkably observed, if these enhancers can be delivered to the large intestine with some poorl...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Fetih G,Lindberg S,Itoh K,Okada N,Fujita T,Habib F,Artersson P,Attia M,Yamamoto A

    更新日期:2005-04-11 00:00:00

  • Selegiline-functionalized, PEGylated poly(alkyl cyanoacrylate) nanoparticles: Investigation of interaction with amyloid-β peptide and surface reorganization.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder for which the research of new treatments is highly challenging. Since the fibrillogenesis of amyloid-β peptide 1-42 (Aβ(1-42)) peptide is considered as a major cause of neuronal degeneration, specific interest has been focused on aromatic molecules for targeting...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Le Droumaguet B,Souguir H,Brambilla D,Verpillot R,Nicolas J,Taverna M,Couvreur P,Andrieux K

    更新日期:2011-09-20 00:00:00

  • A new expanded solubility parameter approach.

    abstract::The partial or Hansen solubility parameters (HSP) are important properties of the various substances and very useful tools for the selection of their solvents or the prediction of their behaviour in numerous applications. Their design and evaluation relies on the basic rule of "similarity matching" for solubility. The...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Stefanis E,Panayiotou C

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Gârea SA,Mihai AI,Ghebaur A,Nistor C,Sârbu A

    更新日期:2015-08-01 00:00:00

  • On the mechanism of reduced tabletability of granules prepared by roller compaction.

    abstract::In a recent paper published in this journal, authors were perplexed by their results seemingly conflicting with our earlier findings [Sun, C.C., Himmelspach, M.W., 2006. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J. Pharm. Sci. 95, 200-206]. After carefully reviewing th...

    journal_title:International journal of pharmaceutics

    pub_type: 评论,信件


    authors: Sun CC

    更新日期:2008-01-22 00:00:00

  • Particle engineering of materials for oral inhalation by dry powder inhalers. II-Sodium cromoglicate.

    abstract::Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler. In the present study we sought to examine the feasibility of producing nanoporous microparticles (NPMPs) of this hydrophilic material by adaptation of a spray drying process pre...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nolan LM,Li J,Tajber L,Corrigan OI,Healy AM

    更新日期:2011-02-28 00:00:00

  • Selection and fabrication of a non-woven polycarbonate urethane cover for a tissue engineered airway stent.

    abstract::One of the major problems in end-stage bronchotracheal cancer is stenosis of the upper airways, either due to luminal ingrowth of the tumor or mucus plugging. Airway stents that suppress tumor ingrowth and sustain mucociliary transport can alleviate these problems in end-stage bronchial cancer. We evaluated different ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Chen W,Clauser J,Thiebes AL,McGrath DJ,McHugh PE,Steinseifer U,Jockenhoevel S,Hennink WE,Kok RJ

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  • Development of Ussing model coupled with artificial membrane for predicting intestinal absorption mechanisms of drugs.

    abstract::The absorption mechanisms of drugs play an important role on development and various application of drugs. However, the present methods of absorption mechanisms are not perfect enough. Hence, exploring a novel method to accurately predict the absorption mechanisms is necessary. In this study, we developed an Ussing mo...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Huang S,Huang Y,Yin X,Wang D,Xiang W,Wang M,Xia Z

    更新日期:2020-04-15 00:00:00

  • Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals.

    abstract::Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-car...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Chu J,Cheng YL,Rao AV,Nouraei M,Zarate-Muñoz S,Acosta EJ

    更新日期:2014-08-25 00:00:00

  • Sinomenine hydrochloride loaded thermosensitive liposomes combined with microwave hyperthermia for the treatment of rheumatoid arthritis.

    abstract::The conventional medications are still facing a huge challenge for the treatment of rheumatoid arthritis (RA). Thus, looking for an effective therapy of RA has became an urgent issue nowadays. In this study, a novel thermosensitive liposome loaded with sinomenine hydrochloride (SIN-TSL) was developed by a pH gradient ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Shen Q,Zhang X,Qi J,Shu G,Du Y,Ying X

    更新日期:2020-02-25 00:00:00

  • Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination.

    abstract::This work reports a novel approach to the assessment of the surface properties of compacts used in Surface Dissolution Imaging (SDI). SDI is useful for determining intrinsic dissolution rate (IDR), an important parameter in early stage drug development. Surface topography, post-compaction and post-SDI run, have been m...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Ward A,Walton K,Box K,Østergaard J,Gillie LJ,Conway BR,Asare-Addo K

    更新日期:2017-09-15 00:00:00

  • Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro.

    abstract::A physiologically pertinent in vitro model is urgently needed for probing interactions between inhaled drugs and the organic cation transporters (OCT) in the bronchial epithelium. This study evaluated OCT expression, functionality, inhibition by common inhaled drugs and impact on formoterol transepithelial transport i...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Mukherjee M,Pritchard DI,Bosquillon C

    更新日期:2012-04-15 00:00:00

  • Dual-responsive lidocaine in situ gel reduces pain of intrauterine device insertion.

    abstract::The most effective and safe contraceptive method, intrauterine devices (IUDs), is still underutilized due to the pain barrier during IUD insertion. Lidocaine, a well-known local anesthetic, can be used to relieve IUD insertion pain. This study aimed at formulation, in vitro, in vivo and clinical evaluation of a novel ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,随机对照试验


    authors: Abd Ellah NH,Abouelmagd SA,Abbas AM,Shaaban OM,Hassanein KMA

    更新日期:2018-03-01 00:00:00

  • Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Shen J,Zhang D,Zhao Z,Jia L,Zheng D,Liu G,Hao L,Zhang Q,Tian X,Li C,Guo H

    更新日期:2013-11-01 00:00:00

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Van Eerdenbrugh B,Froyen L,Martens JA,Blaton N,Augustijns P,Brewster M,Van den Mooter G

    更新日期:2007-06-29 00:00:00

  • In-situ single pass intestinal permeability and pharmacokinetic study of developed Lumefantrine loaded solid lipid nanoparticles.

    abstract::The present investigation aims to develop lumefantrine loaded binary solid lipid nanoparticles (LF-SLNs) to improve its poor and variable oral bioavailability. The oral bioavailability of LF is poor and variable due to its limited aqueous solubility and P-gp mediated efflux occurring in small intestine. LF-SLNs were p...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Garg A,Bhalala K,Tomar DS,Wahajuddin

    更新日期:2017-01-10 00:00:00

  • Design of surface ligands for blood compatible gold nanoparticles: Effect of charge and binding energy.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Beurton J,Lavalle P,Pallotta A,Chaigneau T,Clarot I,Boudier A

    更新日期:2020-04-30 00:00:00

  • Development and characterisation of sustained release solid dispersion oral tablets containing the poorly water soluble drug disulfiram.

    abstract::Administration of drugs via the oral route is the most common and preferred route due to its ease of administration, cost-effectiveness and flexibility in design. However, if the drug being administered has limited aqueous solubility it can result in poor bioavailability. Furthermore, the low pH of the stomach as well...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Shergill M,Patel M,Khan S,Bashir A,McConville C

    更新日期:2016-01-30 00:00:00

  • Development of machine learning models of β-cyclodextrin and sulfobutylether-β-cyclodextrin complexation free energies.

    abstract::A new set of 142 experimentally determined complexation constants between sulfobutylether-β-cyclodextrin and diverse organic guest molecules, and 78 observations reported in literature, were used for the development of the QSPR models by the two machine learning regression methods - Cubist and Random Forest. Similar m...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Merzlikine A,Abramov YA,Kowsz SJ,Thomas VH,Mano T

    更新日期:2011-10-14 00:00:00