Abstract：
:Albumin microparticles have found many applications in diagnosis and treatment in recent years and more than 100 diagnostic agents and drugs have been incorporated into albumin microparticles. In the present study, bovine serum albumin (BSA) based microparticles bearing captopril were prepared by an emulsification-heat stabilization technique. Four batches of microparticles with varying ratio of drug and polymer were prepared. The prepared microparticles were studied for drug loading, particle size distribution, in vitro release characteristics, in vivo tissue distribution study and stability studies. The microparticles had mean diameter between 2 and 11 microm of which more than 70% were below 5 microm and incorporation efficiency of 41-63% was obtained. In vitro release profile for formulations containing captopril-loaded albumin microparticles with heat stabilizing technique shows slow controlled release up to 24 h. The in vivo result of drug-loaded microparticles showed preferential drug targeting to liver followed by lungs, kidneys and spleen. Stability studies showed that maximum drug content and closest in vitro release to initial data were found in the formulation stored at 4 degrees C. In the present study, captopril-loaded BSA microparticles were prepared and targeted to various organs to a satisfactory level and were found to be stable at 4 degrees C.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Dandagi PM,Mastiholimath VS,Patil MB,Gupta MKdoi
10.1016/j.ijpharm.2005.10.025keywords:
subject
Has Abstractpub_date
2006-01-03 00:00:00pages
83-8issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(05)00674-5journal_volume
307pub_type
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2006-09-14 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2004.11.017
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journal_title：International journal of pharmaceutics
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更新日期：1999-10-05 00:00:00
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更新日期：2019-10-05 00:00:00
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pub_type： 杂志文章
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更新日期：2010-12-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0378-5173(03)00023-1
更新日期：2003-04-14 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2005.02.007
更新日期：2005-05-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2004.11.009
更新日期：2005-01-31 00:00:00
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更新日期：2021-01-20 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.ijpharm.2017.02.006
更新日期：2017-04-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2007.01.014
更新日期：2007-06-29 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2013.01.008
更新日期：2013-02-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2003.09.025
更新日期：2004-01-09 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.ijpharm.2007.02.018
更新日期：2007-07-18 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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更新日期：2017-05-30 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2017-10-30 00:00:00
abstract：:Maedi Visna virus (MVV) is an ovine lentivirus with high prevalence all over the world. Since conventional vaccines had failed in protecting animals against the infection, the development of a DNA vaccine can be an alternative. The candidate vaccine was constructed by cloning the sequence encoding MVV p25 protein and ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2009.05.005
更新日期：2009-07-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2019.01.029
更新日期：2019-03-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2005.04.019
更新日期：2005-08-26 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/s0378-5173(98)00370-6
更新日期：1999-02-01 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2017.09.007
更新日期：2018-01-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
doi：10.1016/s0378-5173(98)00335-4
更新日期：1999-03-15 00:00:00
abstract：:Di-isononyl phthalate (DINP) is a general-purpose plasticizer for polyvinyl chloride. However, this industrial chemical plasticizer used as a clouding agent has recently contaminated food and beverages that had been inspected by Taiwan Food and Drug Administration. This study develops a sensitive and specific method c...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2013.04.033
更新日期：2013-06-25 00:00:00
