Abstract：
:Ciclopirox olamine (CPO) metal complexes have been prepared and characterized using elemental analysis, infra red (IR), melting point and differential scanning calorimetry (DSC). Spectroscopic titration using molar ratio method indicated the occurrence of 1:1 complexes for CPO with almost all the examined metals. Physicochemical properties were also studied including aqueous solubility and apparent partition coefficient. Results showed that generally complex formation dramatically decreased the solubility and increased apparent partition coefficient. However, some metal complexes exhibited opposite effect. It could be concluded that complex formation can modify the solubility and apparent partition coefficient, which may suggest the use of complexes to manipulate the physicochemical properties of the drug.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Tarawneh RT,Hamdan II,Bani-Jaber A,Darwish RMdoi
10.1016/j.ijpharm.2004.11.009keywords:
subject
Has Abstractpub_date
2005-01-31 00:00:00pages
179-87issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(04)00644-1journal_volume
289pub_type
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