Abstract：
PURPOSE:Evaluate ex vivo the bacterial metabolism induced degradation rates of mesalamine (negative control), metronidazole and olsalazine in distal ileum and in cecum. METHODS:The contents of distal ileum and cecum were collected during colonoscopy under anaerobic conditions from twelve healthy adults in the fasted and in the fed state. To eliminate potential effects of enzymes that may exist in the fluid of lower intestine, each sample was ultracentrifuged and the precipitate was diluted with a volume of normal saline equivalent to that of the supernatant, after ultracentrifugation of intestinal contents from which the specific precipitate had been obtained. Degradation of the three model drugs in individual materials was evaluated anaerobically. RESULTS:Mesalamine was stable in all cases. Degradation rates of metronidazole and olsalazine were higher in cecum than in distal ileum, only in the fasted state; no trend could be observed in the fed state. Degradation rates of metronidazole and olsalazine were decreased in the fed state in the cecum; no trend could be observed in distal ileum. CONCLUSIONS:In the fasted state, bacterial activity is higher in cecum than in distal ileum. Food residues decrease bacterial metabolism degradation rates of drugs in cecum.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Karatza E,Goumas C,Muenster U,Reppas C,Vertzoni Mdoi
10.1016/j.ijpharm.2017.10.015subject
Has Abstractpub_date
2017-12-20 00:00:00pages
237-241issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30974-2journal_volume
534pub_type
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