Abstract：
:An innovative strategy of fabricating uniform spore like drug particles to improve pulmonary drug delivery efficiency was disclosed in the present study. Spore like particles were prepared through combination of high gravity controlled precipitation and spray drying process with insulin as model drug first, showing rough surface and hollow core. The shell of such spore-like particle was composed of nanoparticles in loose agglomerate and could form nanosuspension upon contacting antisolvent. Further characterization confirmed secondary structure and bio-activity was well preserved in spore like particles of insulin. Stable aerosol performance at different dosages with fine powder fraction (FPF) of 80% and comparable FPF (69-76%) for formulated powder were achieved, significantly higher than marketed product Exubera. On the other hand spore like particles of bovine serum albumin, lysozyme and salbutamol sulfate showed similar high FPF of 80%, regardless of different shape of primary nanoparticles, indicating various application of this new process in significant improvement of pulmonary drug delivery.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Shen ZG,Chen WH,Jugade N,Gao LY,Glover W,Shen JY,Yun J,Chen JFdoi
10.1016/j.ijpharm.2012.03.044subject
Has Abstractpub_date
2012-07-01 00:00:00pages
98-103issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(12)00285-2journal_volume
430pub_type
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