当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media.

Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media.

Abstract：

:The objective of this study was to investigate the integrtity and stability of oral liposomes containing glycocholate (SGC-Lip) in simulated gastrointestinal (GI) media and ex vivo GI media from rats in comparison with conventional liposomes (CH-Lip) composed of soybean phosphatidylcholine and cholesterol. Membrane integrity of liposomes was evaluated by monitoring calcein release, particle size and distribution in different simulated GI media. The stability of liposomes encapsulating insulin was investigated in simulated GI fluids containing pepsin or pancreatin and ex vivo GI enzyme fluids. Simulated GI media with low pH or physiological bile salts resulted in significant increase in calcein release, but dynamic laser scattering data showed that the size and distribution were generally stable. SGC-Lip retained the major amount of the initially encapsulated insulin as compared with CH-Lip in simulated GI fluids (SGF, FaSSGF, SIF and FeSSIF-V2). SGC-Lip retained respectively 17.1% and 20.5% of the initially encapsulated insulin in ex vivo GI fluid, which were also significantly more than CH-Lip. These results suggested that SGC-Lip could protect insulin from degradation to some degree during their transit through the gastrointestinal tract and contributed to enhanced oral absorption.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Hu S,Niu M,Hu F,Lu Y,Qi J,Yin Z,Wu W

doi

10.1016/j.ijpharm.2012.10.025

subject

Has Abstract

pub_date

2013-01-30 00:00:00

pages

693-700

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(12)00965-9

journal_volume

441

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Impact of blend properties on die filling during tableting.

    abstract：:Based on characterization of a wide range of fillers and APIs, thirty divergent blends were composed and subsequently compressed on a rotary tablet press, varying paddle speed and turret speed. The tablet weight variability was determined of 20 grab samples consisting of each 20 tablets. Additionally, the bulk residen...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.08.015

    authors： Van Snick B,Grymonpré W,Dhondt J,Pandelaere K,Di Pretoro G,Remon JP,De Beer T,Vervaet C,Vanhoorne V

    更新日期：2018-10-05 00:00:00

  • Hydrodynamics-induced variability in the USP apparatus II dissolution test.

    abstract：:The USP tablet dissolution test is an analytical tool used for the verification of drug release processes and formulation selection within the pharmaceutical industry. Given the strong impact of this test, it is surprising that operating conditions and testing devices have been selected empirically. In fact, the flow ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.08.003

    authors： Baxter JL,Kukura J,Muzzio FJ

    更新日期：2005-03-23 00:00:00

  • Influence of ethanol on aspirin release from hypromellose matrices.

    abstract：:Release profiles of aspirin from hypromellose matrices in hydro-ethanolic media were studied. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however, dose dumping of aspirin did not occur. An initial rapid release was observed in m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.09.055

    authors： Roberts M,Cespi M,Ford JL,Dyas AM,Downing J,Martini LG,Crowley PJ

    更新日期：2007-03-06 00:00:00

  • Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals.

    abstract：:Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-car...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.05.001

    authors： Chu J,Cheng YL,Rao AV,Nouraei M,Zarate-Muñoz S,Acosta EJ

    更新日期：2014-08-25 00:00:00

  • Optimization of PLG microspheres for tailored drug release.

    abstract：:Here we explore the opportunity to design and then produce tailored release of therapeutic drugs from microcapsules. By use of "building blocks," formed from well characterized microcapsule populations, an inverse design algorithm has been developed that provides an optimal (in a least squares sense) combination of bu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.09.010

    authors： Berchane NS,Jebrail FF,Andrews MJ

    更新日期：2010-01-04 00:00:00

  • Interfacial elastic relaxation during the ejection of bi-layered tablets.

    abstract：:The predilection of a bi-layered tablet to fail in the interface region after its initial formation in the compaction process reduces its practicality as a choice for controlled release solid drug delivery system. Hence, a fundamental appreciation of the governing mechanism that causes the weakening of the interfacial...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.11.031

    authors： Anuar MS,Briscoe BJ

    更新日期：2010-03-15 00:00:00

  • Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines.

    abstract：:Formulations of ultra-deformable liposomes containing bleomycin (Bleosome) have previously been described and proposed for topical treatment of skin cancer [Lau, K.G., Chopra, S., Maitani, Y., 2003. Entrapment of bleomycin in ultra-deformable liposomes. S. T. P. Pharm. Sci. 13, 237-239]. In this study, the stability o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.04.019

    authors： Lau KG,Hattori Y,Chopra S,O'Toole EA,Storey A,Nagai T,Maitani Y

    更新日期：2005-08-26 00:00:00

  • The influence of carrier morphology on drug delivery by dry powder inhalers.

    abstract：:Alpha-lactose monohydrate was prepared to have different morphological features but with similar particle size. The crystal shape and surface smoothness of lactose were quantified by a number of shape descriptors and these were supported qualitatively by the visual examination of scanning electron (SE) micrographs of ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00347-1

    authors： Zeng XM,Martin GP,Marriott C,Pritchard J

    更新日期：2000-04-25 00:00:00

  • Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime.

    abstract：:Radiation sterilisation is a promising method to sterilise pharmaceutical products. However, this process is accompanied by a modification of odour due to volatile compounds formation. The origin of malodorous compounds produced during solid cefotaxime radiosterilisation has been investigated and several mechanisms ar...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(98)00374-3

    authors： Barbarin N,Rollmann B,Tilquin B

    更新日期：1999-02-15 00:00:00

  • Effect of camphor/cyclodextrin complexation on the stability of O/W/O multiple emulsions.

    abstract：:Camphor (CA) encapsulation in oil/water/oil multiple emulsions prepared with cyclodextrin disturbs the emulsifier potential of alpha- and beta-natural cyclodextrins (CD). It was suggested that the size and geometrical fit between the CD cavity and CA could induce CD/CA complex formation in place of emulsifier formatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00261-8

    authors： Yu SC,Bochot A,Bas GL,Chéron M,Mahuteau J,Grossiord JL,Seiller M,Duchêne D

    更新日期：2003-08-11 00:00:00

  • Anticancer effect of X-Ray triggered methotrexate conjugated albumin coated bismuth sulfide nanoparticles on SW480 colon cancer cell line.

    abstract：:The application of nanoparticles (NPs) as radio-sensitizers and carriers has opened up a new horizon to overcome the limitations of chemo and radiotherapy. In this study, bovine serum albumin-coated Bi2S3 NPs (Bi2S3@BSA NPs) were synthesized and evaluated in terms of their ability to be used as a radio-sensitizer and ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119320

    authors： Faghfoori MH,Nosrati H,Rezaeejam H,Charmi J,Kaboli S,Johari B,Danafar H

    更新日期：2020-05-30 00:00:00

  • Strategies for maintaining the particle size of peptide DNA condensates following freeze-drying.

    abstract：:The particle size of peptide DNA condensates were studied after freeze-drying and rehydration as a function of sugar excipient, concentration, pH, DNA concentration, and peptide condensing agent. In the absence of an excipient, freeze-dried 50 microg/ml AlkCWK(18) (iodoacetic acid alkylated Cys-Typ-Lys(18)) DNA conden...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00435-x

    authors： Kwok KY,Adami RC,Hester KC,Park Y,Thomas S,Rice KG

    更新日期：2000-08-10 00:00:00

  • Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process parameters.

    abstract：:Enteric-coated fixed-dose combinations of ezetimibe and lovastatin were prepared by fluid bed coating aiming to avoid the acidic conversion of lovastatin to its hydroxyacid derivative. In a two-step process, sucrose beads were layered with a glass solution of ezetimibe, lovastatin and Soluplus®, top-coated with an ent...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.01.053

    authors： Riekes MK,Dereymaker A,Berben P,Augustijns P,Stulzer HK,Van den Mooter G

    更新日期：2017-03-30 00:00:00

  • Critical attributes of formulation and of elaboration process of PLGA-protein microparticles.

    abstract：:Low drug loading, burst effect during release and drug inactivation account for the main drawbacks of protein microencapsulation in poly(d,l-lactic-co-glycolic) acid (PLGA) matrix by the water-in oil-in water (W/O/W) solvent evaporation method. Thus, the current study was set to invest the critical attributes of formu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.01.008

    authors： Martín-Sabroso C,Fraguas-Sánchez AI,Aparicio-Blanco J,Cano-Abad MF,Torres-Suárez AI

    更新日期：2015-03-01 00:00:00

  • Influence of different parameters on reconstitution of lyophilized SLN.

    abstract：:Drug-loaded solid lipid nanoparticles (SLN) suitable for parenteral administration were freeze-dried. The lipid matrix Imwitor 900 (concentration, 2.5%) was stabilized with Lipoid E 80 and sodium glycocholate. The influence of different parameters of lyophilization like the protective effect of cryoprotectants, freezi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00424-x

    authors： Zimmermann E,Müller RH,Mäder K

    更新日期：2000-03-10 00:00:00

  • Radioprotective effect of self-assembled low molecular weight Fucoidan-Chitosan nanoparticles.

    abstract：:Fucoidan, a sulphated polysaccharide, plays a vital role in reducing cellular oxidative damage by exerting potential antioxidant activity. However, because of the negative surface charges of oligofucoidan, it shows poor oral intestinal absorption. To overcome this drawback, the oligofucoidan polysaccharides self-assem...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119161

    authors： Wu SY,Parasuraman V,Hsieh-Chih-Tsai,Arunagiri V,Gunaseelan S,Chou HY,Anbazhagan R,Lai JY,Prasad N R

    更新日期：2020-04-15 00:00:00

  • Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen.

    abstract：:A novel delivery system based on drug-cyclodextrin (CD) complexation and liposomes has been developed to improve therapeutic effect. Three different means, i.e., co-evaporation (COE), co-ground (GR) and co-lyophilization (COL) and three different CDs (β-CD, HP-β-CD and SBE-β-CD) were contrasted to investigate the char...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.07.011

    authors： Zhang L,Zhang Q,Wang X,Zhang W,Lin C,Chen F,Yang X,Pan W

    更新日期：2015-08-15 00:00:00

  • Cell uptake, cytoplasmic diffusion and nuclear access of a 6.5 nm diameter dendrimer.

    abstract：:Macromolecular crowding and the presence of organelles in the cytosol present barriers to particle mobility, such that it is unclear how nano-carriers can deliver their active agents to the nucleus. In this work a sixth generation amino terminated polyamide polylysine dendrimer (Gly-Lys(63) (NH(2))(64)) (MW 8149, diam...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.12.012

    authors： Ruenraroengsak P,Al-Jamal KT,Hartell N,Braeckmans K,De Smedt SC,Florence AT

    更新日期：2007-03-01 00:00:00

  • Design of a dissolution system for the evaluation of the release rate characteristics of artemether and dihydroartemisinin from tablets.

    abstract：:As none of the pharmacopoeial dissolution methods are suitable to evaluate the release rate of artemether and dihydroartemisinin from tablets, a 'two-phase partition-dissolution' method, based on the one of [J. Pharm. Sci. 85 (1996) 1060] was developed. It consists of an organic solvent in the upper part and the aqueo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.01.022

    authors： Gabriëls M,Plaizier-Vercammen J

    更新日期：2004-04-15 00:00:00

  • Efficient incorporation and protection of lansoprazole in cyclodextrin metal-organic frameworks.

    abstract：:Lansoprazole (LPZ) is an acid pump inhibitor, which readily degrades upon acidic or basic conditions and under heating. We investigated here LPZ stability upon incorporation in particles made of cyclodextrin metal-organic frameworks (CD-MOFs). LPZ loaded CD-MOFs were successfully synthesized, reaching high LPZ payload...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119442

    authors： Li X,Porcino M,Martineau-Corcos C,Guo T,Xiong T,Zhu W,Patriarche G,Péchoux C,Perronne B,Hassan A,Kümmerle R,Michelet A,Zehnacker-Rentien A,Zhang J,Gref R

    更新日期：2020-07-30 00:00:00

  • Preparation, formula optimization and antitumor actions of mannitol coupling camptothecin nanoparticles.

    abstract：:The purpose of this work is to prepare a formulation using mannitol coupling Camptothecin (CPT) nanoparticles (CPT-NPs) to circumvent the difficult solubilization practice based on central composite experimental statistical design. CPT-NPs were prepared with a high-pressure homogenization technique method. The indepen...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.02.019

    authors： Wang Z,Li Q,Zhao X,Sun B,Zhu Q,Gao W,Hua C

    更新日期：2014-04-25 00:00:00

  • Development of novel diolein-niosomes for cutaneous delivery of tretinoin: influence of formulation and in vitro assessment.

    abstract：UNLABELLED:This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol(®), as carriers for cutaneous drug delivery. The model drug was tretinoin and conventional, and Labrasol(®) containing liposomes was used as controls to evaluate the influen...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.10.031

    authors： Manca ML,Manconi M,Nacher A,Carbone C,Valenti D,Maccioni AM,Sinico C,Fadda AM

    更新日期：2014-12-30 00:00:00

  • A novel approach to avoid capping and/or lamination by application of external lower punch vibration.

    abstract：:Capping as well as lamination are two common problems, which affect the resulting product quality of the tablet. Usually, capping and lamination occur during or after tablet manufacturing, and may therefore influence follow-up processes such as the coating. In this context, there is an urgent need for approaches to ov...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119195

    authors： Kalies A,Heinrich T,Leopold CS

    更新日期：2020-04-30 00:00:00

  • Elaboration and evaluation of alginate foam scaffolds for soft tissue engineering.

    abstract：:Controlling microarchitecture in polymer scaffolds is a priority in material design for soft tissue applications. This paper reports for the first time the elaboration of alginate foam-based scaffolds for mesenchymal stem cell (MSC) delivery and a comparative study of various surfactants on the final device performanc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.02.060

    authors： Ceccaldi C,Bushkalova R,Cussac D,Duployer B,Tenailleau C,Bourin P,Parini A,Sallerin B,Girod Fullana S

    更新日期：2017-05-30 00:00:00

  • Dispersibility of lactose fines as compared to API in dry powders for inhalation.

    abstract：:This work investigates the dispersion performance of fine lactose particles as function of processing time, and compares it to the API, using Beclomethasone Dipropionate (BDP) as model API. The total load of fine particles is kept constant in the formulations while the proportions of API and lactose fines are varied. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.03.004

    authors： Thalberg K,Åslund S,Skogevall M,Andersson P

    更新日期：2016-05-17 00:00:00

  • Hydrophobically modified inulin as an amphiphilic carbohydrate polymer for micellar delivery of paclitaxel for intravenous route.

    abstract：:Micellization offers several advantages for the delivery of water insoluble drugs including a nanoparticulate 'core-shell' delivery system for drug targeting. Recently, hydrophobically modified polysaccharides (HMPs) are gaining recognition as micelle forming polymers to encapsulate hydrophobic drugs. In this manuscri...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.01.005

    authors： Muley P,Kumar S,El Kourati F,Kesharwani SS,Tummala H

    更新日期：2016-03-16 00:00:00

  • Measurement of residence time distributions and material tracking on three continuous manufacturing lines.

    abstract：:Over the recent decade, benefits of continuous manufacturing (CM) of pharmaceutical products have been acknowledged widely. In contrast to batch processes, the product is not physically separated into batches in CM, which creates a few challenges. Product release is done for batches that should have a uniform quality ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.03.058

    authors： Karttunen AP,Hörmann TR,De Leersnyder F,Ketolainen J,De Beer T,Hsiao WK,Korhonen O

    更新日期：2019-05-30 00:00:00

  • Cancer treatment in the lymphatic system: A prospective targeting employing nanostructured systems.

    abstract：:Cancer related to lymphangiogenesis has gained a great deal of attention in recent decades ever since specific markers of this intriguing system were discovered. Unlike the blood system, the lymphatic system has unique features that can advance cancer in future metastasis, or, conversely, can provide an opportunity to...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119697

    authors： Yukuyama MN,de Araujo GLB,de Souza A,Löbenberg R,Barbosa EJ,Henostroza MAB,Rocha NPD,de Oliveira IF,Folchini BR,Peroni CM,Masiero JF,Bou-Chacra NA

    更新日期：2020-09-25 00:00:00

  • Drug release from and mechanical properties of press-coated tablets with hydroxypropylmethylcellulose acetate succinate and plasticizers in the outer shell.

    abstract：:Dissolution profiles of diltiazem hydrochloride (DIL) contained in core tablets from press-coated (PC) tablets with hydroxypropylmethylcellulose acetate succinate (HPMCAS) and plasticizers-adsorbent in the outer shell were investigated. Although, on the addition of triethyl citrate (TEC), triacetin (TA), and acetyltri...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00578-6

    authors： Fukui E,Miyamura N,Yoneyama T,Kobayashi M

    更新日期：2001-04-17 00:00:00

  • Application of DoE approach in the development of mini-capsules, based on biopolymers and manuka honey polar fraction, as powder formulation for the treatment of skin ulcers.

    abstract：:The aim of the present work was the development of a powder formulation for the delivery of manuka honey (MH) bioactive components in the treatment of chronic skin ulcers. In particular pectin (PEC)/chitosan glutamate (CS)/hyaluronic acid (HA) mini-capsules were obtained by inverse ionotropic gelation in presence of c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.10.050

    authors： Tenci M,Rossi S,Bonferoni MC,Sandri G,Mentori I,Boselli C,Cornaglia AI,Daglia M,Marchese A,Caramella C,Ferrari F

    更新日期：2017-01-10 00:00:00