Influence of different parameters on reconstitution of lyophilized SLN.

abstract：:Cutaneous delivery of combinations of antioxidants offers the possibility of enhanced protection against UV-radiation. In this study, we investigated the potential of sugar-based microemulsions containing monoglycerides to promote simultaneous cutaneous delivery of lycopene and ascorbic acid, and increase tissue antio...

journal_title：International journal of pharmaceutics

authors： Pepe D,Phelps J,Lewis K,Dujack J,Scarlett K,Jahan S,Bonnier E,Milic-Pasetto T,Hass MA,Lopes LB

更新日期：2012-09-15 00:00:00

abstract：:The thermal properties of two polymorphs (A and C) of a Merck development compound were studied using high-speed differential scanning calorimetry (Hyper-DSC). The utility of this novel technique as a fast analytical tool for studying the polymorphic behaviour of metastable polymorphs has previously been demonstrated ...

journal_title：International journal of pharmaceutics

authors： McGregor C,Bines E

更新日期：2008-02-28 00:00:00

abstract：:This study systematically demonstrated the antigenicity kinetics of HBV vaccine microneedles (MNs) during the fabrication, application and storage. To improve the stability of HBsAg in a microneedle patch, several selected saccharides were added to the MN formulations as stabilizers. According to the experimental data...

journal_title：International journal of pharmaceutics

authors： Zhu DD,Zhang XP,Yu HL,Liu RX,Shen CB,Zhang WF,Cui Y,Guo XD

更新日期：2019-08-15 00:00:00

abstract：:The poly(cystaminebis(acrylamide)-diaminohexane) (poly(CBA-DAH)) was designed previously as a bio-reducible efficient gene delivery carrier. However, the high weight ratio required to form the polyplexes between poly(CBA-DAH) with pDNA is still a problem that needs to be addressed. To solve this problem and increase t...

journal_title：International journal of pharmaceutics

authors： Nam JP,Kim S,Kim SW

更新日期：2018-07-10 00:00:00

abstract：:The objective of the present study was to evaluate three formulation parameters for the application of polymethacrylic films from aqueous dispersions in order to obtain multiparticulate sustained release of diclofenac sodium. Film coating of pellet cores was performed in a laboratory fluid bed apparatus. The chosen in...

journal_title：International journal of pharmaceutics

authors： Kramar A,Turk S,Vrecer F

更新日期：2003-04-30 00:00:00

abstract：:Squamous cell carcinoma treatment has limited therapeutic options and the incidence rate is increasing recently. In the present investigation, we developed poly(lactic-co-glycolic acid) (PLGA) nanopatterned films (NPFs) through poly dimethyl siloxane (PDMS) cast molding technique and explored its therapeutic efficacy ...

journal_title：International journal of pharmaceutics

authors： Malathi S,Pavithra PS,Sridevi S,Verma RS

更新日期：2020-03-30 00:00:00

abstract：:Nanocarriers may provide interesting delivery platforms for microbicide drugs and their characterization should be addressed early in development. Differently surface-engineered dapivirine-loaded, poly(epsilon-caprolactone) (PCL)-based nanoparticles (NPs) were obtained by nanoprecipitation using polyethylene oxide (PE...

journal_title：International journal of pharmaceutics

authors： das Neves J,Amiji M,Bahia MF,Sarmento B

更新日期：2013-11-18 00:00:00

abstract：:Sodium salts are often used in drug formulation but their partial solubility parameters are not available. Sodium alters the physical properties of the drug and the knowledge of these parameters would help to predict adhesion properties that cannot be estimated using the solubility parameters of the parent acid. This ...

journal_title：International journal of pharmaceutics

authors： Bustamante P,Pena MA,Barra J

更新日期：2000-01-20 00:00:00

abstract：:Primary objective of this investigation was to delineate the differential impact of efflux transporters P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) on brain disposition and plasma pharmacokinetics of pazopanib. In addition, this research investigated whether inhibition of these efflu...

journal_title：International journal of pharmaceutics

authors： Minocha M,Khurana V,Qin B,Pal D,Mitra AK

更新日期：2012-10-15 00:00:00

abstract：BACKGROUND:Pulmonary administration of the antimicrobial drugs colistin sulphomethate and tobramycin has been shown to be effective in slowing down pulmonary deterioration in cystic fibrosis (CF) patients. Both drugs are administered by liquid nebulisation, a technique known to have disadvantages. Dry powder inhalation...

journal_title：International journal of pharmaceutics

authors： Westerman EM,de Boer AH,Le Brun PPH,Touw DJ,Frijlink HW,Heijerman HGM

更新日期：2007-04-20 00:00:00

abstract：:Hesperetin, an aglycone of the flavanone hesperidin, is a potential candidate for the treatment of diabetic retinopathy and macular edema. The purpose of this investigation was to determine solubility, stability and in vitro permeability characteristics of hesperetin across excised rabbit corneas. Aqueous and pH depen...

journal_title：International journal of pharmaceutics

authors： Srirangam R,Majumdar S

更新日期：2010-07-15 00:00:00

abstract：:The six fragrances, camphor, citronellal, eucalyptol, limonene, menthol and 4-tert-butylcyclohexyl acetate, which represent different chemical functionalities, were encapsulated with a polymer-blend of ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC) and poly(vinyl alcohol) (PV(OH)) using solvent displacement...

journal_title：International journal of pharmaceutics

authors： Sansukcharearnpon A,Wanichwecharungruang S,Leepipatpaiboon N,Kerdcharoen T,Arayachukeat S

更新日期：2010-05-31 00:00:00

abstract：:A multivariate TOF-SIMS methodology has been developed and applied to quantify surface composition and chemical distribution for dry powder blends. Surface properties are often critical to the behavior of powder formulations, especially in the case of dry powders for inhalation, as surface properties directly affect i...

journal_title：International journal of pharmaceutics

authors： Nicholas M,Josefson M,Fransson M,Wilbs J,Roos C,Boissier C,Thalberg K

更新日期：2020-09-25 00:00:00

abstract：:An investigation was carried out to determine the behavior of moisture gain by four anti-tuberculosis drugs, viz. rifampicin, isoniazid, pyrazinamide and ethambutol, when exposed in pure form and in combinations to accelerated conditions of 40 degrees C and 75% RH, in the absence and the presence of light. Weight gain...

journal_title：International journal of pharmaceutics

authors： Singh S,Bhutani H,Mariappan TT,Kaur H,Bajaj M,Pakhale S

更新日期：2002-10-01 00:00:00

abstract：:The content of latanoprost, a therapeutic drug for glaucoma, is likely to decrease in solution. In a previous study, we confirmed that this was associated with latanoprost adsorption to the container and hydrolysis of latanoprost, and established a formulation of latanoprost eye drop solution that can be stored at roo...

journal_title：International journal of pharmaceutics

authors： Ochiai A,Ohkuma M,Danjo K

更新日期：2012-10-15 00:00:00

abstract：:The purpose of this study is to improve the solubility, in vitro dissolution, and oral bioavailability in rats of tadalafil (TDF) by using SD technique with a weak acid and a copolymer. TDF-SD was prepared via solvent evaporation, coupled with the incorporation of an acidifier and solubilizer. Tartaric acid enhanced t...

journal_title：International journal of pharmaceutics

authors： Choi JS,Kwon SH,Lee SE,Jang WS,Byeon JC,Jeong HM,Park JS

更新日期：2017-06-30 00:00:00

abstract：:The purpose of this study is to establish a novel approach for preparing a solid dispersion drug product using spherical silicate by a Wurster-type fluidized bed granulator. The spherical silicate used in this study has porous structure and ideal particle size for loading by a Wurster-type fluidized bed granulator. As...

journal_title：International journal of pharmaceutics

authors： Nagane K,Kimura S,Ukai K,Ogawa N,Yamamoto H

更新日期：2014-11-20 00:00:00

abstract：:In this proof-of-concept study, a methodology is proposed to systematically analyze large data historians of secondary pharmaceutical manufacturing systems using data mining techniques. The objective is to develop an approach enabling to automatically retrieve operation-relevant information that can assist the managem...

journal_title：International journal of pharmaceutics

authors： Meneghetti N,Facco P,Bezzo F,Himawan C,Zomer S,Barolo M

更新日期：2016-05-30 00:00:00

abstract：:The ex vivo buccal permeability of a [D-Ala(2), D-Leu(5)]enkephalin (DADLE) and glyceryl monooleate (GMO) was examined from the cubic and lamellar liquid crystalline phases of GMO and aqueous phosphate-buffered saline (pH 7.4, PBS) solution across excised porcine buccal mucosa mounted in a Franz cell. GMO was released...

journal_title：International journal of pharmaceutics

authors： Lee J,Kellaway IW

更新日期：2000-02-15 00:00:00

abstract：:The effects of addition of divalent cations and phosphate buffer on the degree of beta-carotene encapsulation in a mannitol matrix during freeze-drying were analyzed. The degradation rate of encapsulated beta-carotene as a function of % RH and its relationship with the physical state of the matrix during storage at 25...

journal_title：International journal of pharmaceutics

authors： Sutter SC,Buera MP,Elizalde BE

更新日期：2007-03-06 00:00:00

abstract：:The low bioavailability of poorly water-soluble drugs is currently one of the major focuses of pharmaceutical research. One strategy currently being investigated to overcome this limitation is to decrease the particle size of the active pharmaceutical ingredients (API). An innovative process for this is spray drying w...

journal_title：International journal of pharmaceutics

authors： Dobrowolski A,Strob R,Nietfeld J,Pieloth D,Wiggers H,Thommes M

更新日期：2018-09-05 00:00:00

abstract：:The present study evaluates the effect of L-leucine concentration and operating parameters of a laboratory spray dryer on characteristics of trehalose dry powders, with the goal of optimizing production of these powders for inhaled drug delivery. Trehalose/L-leucine mixtures were spray dried from aqueous solution usin...

journal_title：International journal of pharmaceutics

authors： Focaroli S,Mah PT,Hastedt JE,Gitlin I,Oscarson S,Fahy JV,Healy AM

更新日期：2019-05-01 00:00:00

abstract：:The required replacement of chlorofluorocarbon (CFC) with hydrofluoroalkane (HFA) propellants has challenged formulators of pressurized metered dose inhalers in several major respects. Conventional (CFC soluble) surfactants are effectively insoluble in the major CFC replacement candidates, HFA 134 and HFA 227ea, in th...

journal_title：International journal of pharmaceutics

authors： Vervaet C,Byron PR

更新日期：1999-09-10 00:00:00

abstract：:Many medicines prescribed for children are unlicensed. Solid dosage forms present problems as children have difficulty swallowing whole tablets or capsules. When medicines are not licensed for children, it is unlikely that there will be a suitable, licensed liquid formulation and so extemporaneous liquid preparations ...

journal_title：International journal of pharmaceutics

authors： Standing JF,Tuleu C

更新日期：2005-08-26 00:00:00

abstract：:The blending process is a key step in the production of dry powder inhaler formulations, but only little is known about the influence of process parameters. This is especially true for high shear blending of ternary formulations. For this reason, this study aims to investigate the influence of high shear mixing proces...

journal_title：International journal of pharmaceutics

authors： Hertel M,Schwarz E,Kobler M,Hauptstein S,Steckel H,Scherließ R

更新日期：2017-12-20 00:00:00

abstract：:Particle detection and analysis techniques are essential in biopharmaceutical industries to evaluate the quality of various parenteral formulations regarding product safety, product quality and to meet the regulations set by the authority agencies. Several particle analysis systems are available on the market, but for...

journal_title：International journal of pharmaceutics

authors： Gross-Rother J,Herrmann N,Blech M,Pinnapireddy SR,Garidel P,Bakowsky U

更新日期：2018-05-30 00:00:00

abstract：:An aqueous nanoparticle delivery system has been developed which employs the oppositely charged polymers polyethylenimine (PEI) and dextran sulfate (DS) with zinc as a stabilizer. It is found that the pH of PEI solutions, the weight ratio of the two polymers, and zinc sulfate concentrations all play significant roles ...

journal_title：International journal of pharmaceutics

authors： Tiyaboonchai W,Woiszwillo J,Sims RC,Middaugh CR

更新日期：2003-04-14 00:00:00

abstract：:Physical and chemical structure of paclitaxel (PTX) was studied after its incorporation into polymeric micelles made of hyaluronic acid (HA) (Mw=15 kDa) grafted with C6 or C18:1 acyl chains. PTX was physically incorporated into the micellar core by solvent evaporation technique. Maximum loading capacity for HAC6 and H...

journal_title：International journal of pharmaceutics

authors： Smejkalová D,Nešporová K,Hermannová M,Huerta-Angeles G,Cožíková D,Vištejnová L,Safránková B,Novotný J,Kučerík J,Velebný V

更新日期：2014-05-15 00:00:00

abstract：:To avoid the clinical inconvenience of repeated injection of the immune modulator thymopentin (TP5), biodegradable implants comprising a mixed polymer matrix of poly(lactide acid) (PLA) and poly(lactide-co-glycolide acid) (PLGA) were produced using a simple extrusion method. Drug release from these TP5-loaded implants...

journal_title：International journal of pharmaceutics

authors： Wei G,Jin L,Xu L,Liu Y,Lu W

更新日期：2010-10-15 00:00:00

abstract：:The purpose of this study was to prepare solid SMEDDS (sSMEDDS) particles produced by spray-drying using maltodextrin (MD), hypromellose (HPMC), and a combination of the two as a solid carrier. Naproxen (NPX) as the model drug was dissolved (at 6% concentration) or partially suspended (at 18% concentration) in a liqui...

journal_title：International journal of pharmaceutics

authors： Čerpnjak K,Zvonar A,Vrečer F,Gašperlin M

更新日期：2015-05-15 00:00:00