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Behavior of uptake of moisture by drugs and excipients under accelerated conditions of temperature and humidity in the absence and the presence of light. 1. Pure anti-tuberculosis drugs and their combinations.

Abstract：

:An investigation was carried out to determine the behavior of moisture gain by four anti-tuberculosis drugs, viz. rifampicin, isoniazid, pyrazinamide and ethambutol, when exposed in pure form and in combinations to accelerated conditions of 40 degrees C and 75% RH, in the absence and the presence of light. Weight gain was seen only in those samples that contained ethambutol, and this behavior was observed both in dark and lighted chambers. There was a decrease in moisture uptake with an increase in the number of drugs in the mixture. Another observation was a higher weight gain by the mixture of ethambutol and isoniazid in a dark chamber, than either pure ethambutol or drug combinations containing ethambutol. The most interesting finding was an overall acceleration of weight gain in the presence of light as compared with dark conditions, which is a hitherto unknown phenomenon.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Singh S,Bhutani H,Mariappan TT,Kaur H,Bajaj M,Pakhale S

doi

10.1016/s0378-5173(02)00340-x

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

37-44

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S037851730200340X

journal_volume

245

pub_type

杂志文章

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