Abstract：
:Isomalt, a sugar alcohol, was melt-extruded prior to compression in order to improve its tabletting properties. After fusion, crystalline isomalt was transformed into an amorphous form as shown by X-ray diffraction and differential scanning calorimetry (DSC). The tabletting properties of amorphous isomalt were dramatically improved. Mixtures formulated with paracetamol (50%) and extruded isomalt yielded hard tablets. However, extruded isomalt powder showed agglomeration problems due to recrystallization of the amorphous phase into a stable crystalline form in the presence of atmospheric moisture. The evolution of the moisture content correlated well with the compressibility data. The tablets made of extruded isomalt powder had a lower friability in comparison to the tablets formulated with non-extruded isomalt powder. Their disintegration was fast and a rapid dissolution rate was recorded. Extruded isomalt displayed excellent tabletting properties; however, further experiments should be conducted to delay or even prevent recrystallization of amorphous isomalt.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Ndindayino F,Henrist D,Kiekens F,Van den Mooter G,Vervaet C,Remon JPdoi
10.1016/s0378-5173(01)00993-0keywords:
subject
Has Abstractpub_date
2002-03-20 00:00:00pages
149-57issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517301009930journal_volume
235pub_type
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