Abstract：
:Extrusion-spheronisation was used to generate smooth, highly spherical granules of a microcrystalline cellulose/propyl gallate/water paste. Freeze-drying retained the shape and size of the granules, whereas oven-drying produced roughened granules due to the uneven shrinkage of the wet powders. Compaction of one size fraction indicated that the granule strength differed noticeably, with the oven-dried samples producing tablets of lower voidage for a given applied compaction pressure. There was a reasonable correlation between tablet crushing strength and voidage. Major differences were observed in tablet dissolution, with the freeze-dried material exhibiting a two-regime behaviour and an initial dissolution rate constant an order of magnitude greater than the oven-dried form. Both the voidage and dissolution characteristics are postulated to be determined by the microstructure established during drying.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Song B,Rough SL,Wilson DIdoi
10.1016/j.ijpharm.2006.09.050subject
Has Abstractpub_date
2007-03-06 00:00:00pages
38-44issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(06)00776-9journal_volume
332pub_type
杂志文章abstract：:The effect of 35 newly synthesized O-ethylmenthol (MET) derivatives on percutaneous absorption of ketoprofen was investigated in rats. In order to understand the relationship between the structure of compounds and promoting activity (structure-activity relationship), an artificial neural network (ANN) was employed. In...
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2008-05-22 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2002-10-24 00:00:00
