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Supramolecular nanoassemblies of salmon calcitonin and aspartame for fibrillation inhibition and osteogenesis improvement.

Abstract：

:Osteoporosis therapy consists of inhibiting the osteoclasts' activity and promoting osteoblasts' osteogenesis. Salmon calcitonin (sCT) could realize both requirements, however, it is limited by the low bioavailability caused by fibrillation. Supramolecular assembly of sCT and biocompatible agents into nanoassemblies provides an opportunity to overcome these shortcomings. Herein, we used a facile method to fabricate salmon calcitonin-aspartame (sCT-APM) nanoassemblies. Supramolecular interactions could not only delay fibrillation time (from 36.9 h to 50.4 h), but also achieve sustained sCT release. Moreover, sCT-APM showed good biocompatibility and higher osteoinductive capacity than free sCT, revealing an osteogenesis improvement effect. Moreover, in vivo studies showed that sCT-APM has enhanced relative bioavailability (2.42-fold of sCT) and increased relative therapeutic efficacy (3.55-fold of sCT) through subcutaneous injection. These findings provide a convenient alternative strategy for osteoporosis therapy via supramolecular assemblies.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Yu P,Xu Z,Zhai X,Liu Y,Sun H,Xu X,Xie J,Li J

doi

10.1016/j.ijpharm.2020.120171

subject

Has Abstract

pub_date

2021-01-25 00:00:00

pages

120171

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(20)31156-X

journal_volume

593

pub_type

杂志文章

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