Abstract：
:Raman spectroscopy may be implemented through a microscope to provide fine scale axial and lateral chemical maps. The molecular structure of many drugs makes Raman spectroscopy particularly well suited to the investigation of pharmaceutical systems. Chemometric methods currently used to assess bulk Raman spectroscopic data are typically applied to Raman mapping data from pharmaceuticals; few reports exist where the spatial information inherent to a mapped dataset is used for the calculation of chemical maps. Both univariate and multivariate methods have been applied to Raman mapping data to determine the distribution of active pharmaceutical ingredients (APIs) in tablets, solid dispersions for increased solubility and controlled release devices. The ability to axially (depth) profile using Raman mapping has been used in studies of API penetration through membranes, cellular uptake of drug delivery liposomes, and initial API distribution and subsequent elution from coatings of medical devices. New instrumental developments will increase the efficiency of Raman mapping and lead to greater utilisation of Raman mapping for analyses of pharmaceutical systems.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Gordon KC,McGoverin CMdoi
10.1016/j.ijpharm.2010.12.030subject
Has Abstractpub_date
2011-09-30 00:00:00pages
151-62issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(10)00971-3journal_volume
417pub_type
杂志文章,评审abstract：:Coating thickness is the most important attribute of coated pharmaceutical pellets as it directly affects release profiles and stability of the drug. Quality control of the coating process of pharmaceutical pellets is thus of utmost importance for assuring the desired end product characteristics. A visual imaging tech...
journal_title：International journal of pharmaceutics
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更新日期：2014-08-15 00:00:00
abstract：:In current pharmaceutical drug discovery, most candidates are poorly soluble in water, which can result in poor bioavailability. To overcome this problem, formulations that create supersaturation of the drug are a well-studied alternative. Characterizing the dissolution from these systems is challenging because conven...
journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2019-02-25 00:00:00
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journal_title：International journal of pharmaceutics
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doi：10.1016/j.ijpharm.2010.01.001
更新日期：2010-03-30 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2020-11-30 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2015-11-10 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-12-10 00:00:00
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更新日期：2005-05-13 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2011-11-28 00:00:00
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journal_title：International journal of pharmaceutics
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doi：10.1016/j.ijpharm.2014.09.003
更新日期：2014-11-20 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2004-05-19 00:00:00
