当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Physical ageing and thermal analysis of PLGA microspheres encapsulating protein or DNA.

Physical ageing and thermal analysis of PLGA microspheres encapsulating protein or DNA.

Abstract：

:PLGA microspheres undergo physical ageing but their ageing kinetics have not been reported, nor the effect of encapsulated protein or plasmid DNA on any associated changes to the glass transition. Differential scanning calorimetry (DSC) was used to measure the rate of ageing of various PLGA microsphere formulations, with temperature-modulated DSC used to accurately measure the associated glass transition. The Cowie-Ferguson model was applied to determine the parameters describing the enthalpy relaxation kinetics. We show that encapsulated proteins had no significant effect on the glass transition of the microspheres, whereas DNA and PVA were mild antiplasticising agents, particularly with high Mw PLGA. Physical ageing occurred through a range of enthalpy relaxation times (or modes) and was independent of both encapsulated protein and surfactant used during microsphere preparation. Analysis of accelerated ageing at 35 degrees C gave calculated enthalpy relaxation times to thermal equilibrium of 280-400 h. No ageing was observed < or = 10 degrees C and at 25 degrees C estimated relaxation times were at least one order of magnitude greater than at 35 degrees C. Ageing of PLGA microspheres therefore occurs at temperatures >10 degrees C, but relaxation will be far from equilibrium unless storage times and/or temperatures are prolonged or nearing the glass transition, respectively.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Rouse JJ,Mohamed F,van der Walle CF

doi

10.1016/j.ijpharm.2007.02.026

subject

Has Abstract

pub_date

2007-07-18 00:00:00

pages

112-20

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(07)00199-8

journal_volume

339

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Localized drug delivery with mono and bilayered mucoadhesive films and wafers for oral mucosal infections.

    abstract：:Local drug delivery into oral cavity offers many advantages over systemic administration in treatment of the oral infections. In this study, monolayer and bilayered mucoadhesive film and wafer formulations were developed as local drug delivery platforms using chitosan and hydroxypropyl methylcellulose (HPMC). Cefuroxi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.029

    authors： Timur SS,Yüksel S,Akca G,Şenel S

    更新日期：2019-03-25 00:00:00

  • Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime.

    abstract：:Radiation sterilisation is a promising method to sterilise pharmaceutical products. However, this process is accompanied by a modification of odour due to volatile compounds formation. The origin of malodorous compounds produced during solid cefotaxime radiosterilisation has been investigated and several mechanisms ar...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(98)00374-3

    authors： Barbarin N,Rollmann B,Tilquin B

    更新日期：1999-02-15 00:00:00

  • Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum.

    abstract：:Niacinamide-containing moisturisers are known be efficacious in alleviating dry skin conditions and improving stratum corneum (SC) barrier function. However, the mechanisms of action of niacinamide at the molecular level in the SC are still not well understood. Previously, we have reported the development of novel met...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijpharm.2012.11.043

    authors： Mohammed D,Crowther JM,Matts PJ,Hadgraft J,Lane ME

    更新日期：2013-01-30 00:00:00

  • Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells.

    abstract：:Extracellular vesicles (exosomes, EVs) are cell membrane particles (30-200 nm) secreted by virtually all cells. During intercellular communication in the body, secreted EVs play crucial roles by carrying functional biomolecules (e.g., microRNAs and enzymes) into other cells to affect cellular function, including disea...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118762

    authors： Takenaka T,Nakai S,Katayama M,Hirano M,Ueno N,Noguchi K,Takatani-Nakase T,Fujii I,Kobayashi SS,Nakase I

    更新日期：2019-12-15 00:00:00

  • Characterisation of solid dispersions of paracetamol and EUDRAGIT E prepared by hot-melt extrusion using thermal, microthermal and spectroscopic analysis.

    abstract：:Hot-melt extrusion has attracted considerable interest within the pharmaceutical industry. However, there remains some uncertainty as to how to characterise the physical structure of the extruded systems, particularly in terms of identifying the nature of the drug dispersion within the polymer. The aim of the study wa...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.11.048

    authors： Qi S,Gryczke A,Belton P,Craig DQ

    更新日期：2008-04-16 00:00:00

  • Permeation studies through porcine small intestine of furosemide solutions for personalised paediatric administration.

    abstract：:Personalized medicine is a challenging research area in paediatric drug design since no suitable pharmaceutical forms are currently available. Furosemide is an anthranilic acid derivative used in paediatric practice to treat cardiac and pulmonary disorders in premature infants and neonates. However, it is not commerci...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.08.059

    authors： Provenza N,Calpena AC,Mallandrich M,Sánchez A,Egea MA,Clares B

    更新日期：2014-11-20 00:00:00

  • Phase behavior of itraconazole-phenol mixtures and its pharmaceutical applications.

    abstract：:The aims of this study were to examine the phase behavior of itraconazole-phenol mixtures and assess the feasibility of topical formulations of itraconazole using eutectic mixture systems. Itraconazole-phenol eutectic mixtures were characterized using differential scanning calorimetry, Fourier transform infrared spect...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.054

    authors： Park CW,Mansour HM,Oh TO,Kim JY,Ha JM,Lee BJ,Chi SC,Rhee YS,Park ES

    更新日期：2012-10-15 00:00:00

  • Improvement of absorption enhancing effects of n-dodecyl-beta-D-maltopyranoside by its colon-specific delivery using chitosan capsules.

    abstract：:In general, absorption enhancing effects of various absorption enhancers were greater in the large intestine than those in the small intestinal regions. Therefore, the effectiveness of absorption enhancers is expected to be remarkably observed, if these enhancers can be delivered to the large intestine with some poorl...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.12.017

    authors： Fetih G,Lindberg S,Itoh K,Okada N,Fujita T,Habib F,Artersson P,Attia M,Yamamoto A

    更新日期：2005-04-11 00:00:00

  • WITHDRAWN: Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays.

    abstract：:This article has been withdrawn at the request of the authors. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.11.046

    authors： Demir YK,Akan Z,Kerimoglu O

    更新日期：2012-12-20 00:00:00

  • A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles.

    abstract：:Iron (Fe) loaded solid lipid nanoparticles (SLN's) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption. Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed betwee...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.08.070

    authors： Zariwala MG,Elsaid N,Jackson TL,Corral López F,Farnaud S,Somavarapu S,Renshaw D

    更新日期：2013-11-18 00:00:00

  • Amorphous drug dispersions with mono- and diacyl lecithin: On molecular categorization of their feasibility and UV dissolution imaging.

    abstract：:There is a growing interest in drug-phospholipid complexes and similar formulations that are mostly solid dispersions with high drug load. This study aims to explore the feasibility of such phospholipid-based solid dispersions as well as to characterize them. A particular aim was to compare monoacyl phosphatidylcholin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.06.039

    authors： Gautschi N,Van Hoogevest P,Kuentz M

    更新日期：2015-08-01 00:00:00

  • Lipoprotein imitating nanoparticles: Lecithin coating binds ApoE and mediates non-lysosomal uptake leading to transcytosis over the blood-brain barrier.

    abstract：:Lipoproteins are naturally occurring nano sized transport vehicles in the human body. Therefore, lipoproteins could be applied as a drug carrier system. Additionally, several reports of apolipoprotein mediated blood-brain barrier (BBB) crossing suggest lipoprotein mimicking nanoparticles (NPs) as possible drug deliver...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119821

    authors： Wünsch A,Mulac D,Langer K

    更新日期：2020-08-28 00:00:00

  • pH-responsive PepFect cell-penetrating peptides.

    abstract：:A series of cell-penetrating PepFect peptide analogues was developed by substitutions of the galanin-derived N-terminal sequence. Histidine modifications were incorporated in order to make the peptides pH-responsive. The peptides were all able to form non-covalent complexes with an oligonucleotide cargo by co-incubati...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.01.055

    authors： Regberg J,Vasconcelos L,Madani F,Langel Ü,Hällbrink M

    更新日期：2016-03-30 00:00:00

  • Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery.

    abstract：:Emulsion technology has been utilized extensively in the pharmaceutical industry. This article presents a comprehensive review of the literature on an important subcategory of emulsions, microemulsions. Microemulsions are optically transparent, thermodynamically stable colloidal systems, 10-100nm diameter, that form s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.05.005

    authors： Callender SP,Mathews JA,Kobernyk K,Wettig SD

    更新日期：2017-06-30 00:00:00

  • Characterization and aerodynamic evaluation of spray dried recombinant human growth hormone using protein stabilizing agents.

    abstract：:The effect of the protein stabilizers on the stability and aerosol performance of spray dried recombinant human growth hormone (SD rhGH) was investigated. rhGH solution was spray dried alone, with polysorbate 20 (at three concentrations of 0.05%, 0.01%, and 0.005%), Zn(2+) (by Zn(2+):rhGH molar ratio of 2:1 and 4:1), ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.10.053

    authors： Jalalipour M,Gilani K,Tajerzadeh H,Najafabadi AR,Barghi M

    更新日期：2008-03-20 00:00:00

  • Enabling real time release testing by NIR prediction of dissolution of tablets made by continuous direct compression (CDC).

    abstract：:A method for predicting dissolution profiles of directly compressed tablets for a fixed sustained release formulation manufactured in a continuous direct compaction (CDC) system is presented. The methodology enables real-time release testing (RTRt). Tablets were made at a target drug concentration of 9% Acetaminophen,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.08.033

    authors： Pawar P,Wang Y,Keyvan G,Callegari G,Cuitino A,Muzzio F

    更新日期：2016-10-15 00:00:00

  • Using deconvolution to understand the mechanism for variable plasma concentration-time profiles after intramuscular injection.

    abstract：:To introduce better antibiotics for the treatment of some infectious diseases in sheep and to expand the range of antibiotics available for veterinary medicine, pharmacokinetics of two antibiotics marbofloxacin (MBX) and trovafloxacin (TVX) were investigated in sheep after intramuscular injection. Variable and irregul...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.01.046

    authors： Mahmood AH,Liu X,Grice JE,Medley GA,Roberts MS

    更新日期：2015-03-15 00:00:00

  • 3D printed drug products: Non-destructive dose verification using a rapid point-and-shoot approach.

    abstract：:Three-dimensional printing (3DP) has the potential to cause a paradigm shift in the manufacture of pharmaceuticals, enabling personalised medicines to be produced on-demand. To facilitate integration into healthcare, non-destructive characterisation techniques are required to ensure final product quality. Here, the us...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.08.002

    authors： Trenfield SJ,Goyanes A,Telford R,Wilsdon D,Rowland M,Gaisford S,Basit AW

    更新日期：2018-10-05 00:00:00

  • Water solubilization capacity of pharmaceutical microemulsions based on Peceol®, lecithin and ethanol.

    abstract：:Biocompatible microemulsions composed of Peceol(®), lecithin, ethanol and water developed for encapsulation of hydrophilic drugs were investigated. The binary mixture Peceol(®)/ethanol was studied first. It was shown that the addition of ethanol to pure Peceol(®) has a significant fluidifying and disordering effect on...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.07.018

    authors： Mouri A,Diat O,Lerner DA,El Ghzaoui A,Ajovalasit A,Dorandeu C,Maurel JC,Devoisselle JM,Legrand P

    更新日期：2014-11-20 00:00:00

  • Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates.

    abstract：:The formation of extracellular aggregates built up by deposits of β-amyloid (Aβ) is a hallmark of Alzheimer's disease (AD). Curcumin has been reported to display anti-amyloidogenic activity, not only by inhibiting the formation of new Aβ aggregates, but also by disaggregating existing ones. However, the uptake of Curc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.05.015

    authors： Barbara R,Belletti D,Pederzoli F,Masoni M,Keller J,Ballestrazzi A,Vandelli MA,Tosi G,Grabrucker AM

    更新日期：2017-06-30 00:00:00

  • Stability study of amorphous valdecoxib.

    abstract：:Formulation of poorly water-soluble drugs in the most stable dosage form for oral delivery perhaps presents the greatest challenge to pharmaceutical industry. Physical transformation of drug substance into its more soluble but metastable amorphous form is one of the approaches for improving dissolution rate of such dr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.06.009

    authors： Ambike AA,Mahadik KR,Paradkar A

    更新日期：2004-09-10 00:00:00

  • Thermosensitivity and release from poly N-isopropylacrylamide-polylactide copolymers.

    abstract：:A series of thermoresponsive-co-biodegradable polymers, containing varying molar ratios of N-isopropylacrylamide (NIPA) and poly-lactic acid diacrylate macromer (PLAM) were prepared and characterised. Chemical structures were confirmed by nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR). The hydr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.08.036

    authors： Chearúil FN,Corrigan OI

    更新日期：2009-01-21 00:00:00

  • Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy.

    abstract：:There is evidence that swallowing issues and dysphagia are an increasing problem of the aging population in the coming decades that is affecting oral medication administration. There is a variety of clinical expressions of swallowing dysfunction caused by aging, acute or chronic disease conditions, decline in physiolo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2012.04.022

    authors： Stegemann S,Gosch M,Breitkreutz J

    更新日期：2012-07-01 00:00:00

  • Limited drug solubility can be decisive even for freely soluble drugs in highly swollen matrix tablets.

    abstract：:The aim of this study was to elucidate the importance of potential limited solubility effects for the control of drug release from hydrophilic matrix tablets loaded with a freely water-soluble drug. It is often assumed that the considerable amounts of water penetrating into this type of advanced drug delivery systems ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.05.001

    authors： Siepmann F,Karrout Y,Gehrke M,Penz FK,Siepmann J

    更新日期：2017-06-30 00:00:00

  • Application of a chromatic confocal measurement system as new approach for in-line wet film thickness determination in continuous oral film manufacturing processes.

    abstract：:The key parameter of the oral film production process is the wet film thickness since it regulates the active pharmaceutical ingredient (API) content of the finished product. There is no general recommendation on how to adjust the gap height of the coating knife during the film manufacturing process to obtain the targ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.09.028

    authors： Niese S,Quodbach J

    更新日期：2018-11-15 00:00:00

  • Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir.

    abstract：:The objective of this study was to synthesize and evaluate novel enzymatically stable dipeptide prodrugs for improved absorption of acyclovir. l-Valine-l-valine-acyclovir (LLACV), l-valine-d-valine-acyclovir (LDACV), d-valine-l-valine-acyclovir (DLACV) and d-valine-d-valine-acyclovir (DDACV) were successfully synthesi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.05.024

    authors： Talluri RS,Samanta SK,Gaudana R,Mitra AK

    更新日期：2008-09-01 00:00:00

  • Skin penetration and deposition of carboxyfluorescein and temoporfin from different lipid vesicular systems: In vitro study with finite and infinite dosage application.

    abstract：:The aim of the present research is to evaluate the influence of different lipid vesicular systems as well as the effect of application mode on skin penetration and deposition behaviors of carboxyfluorescein (hydrophilic model drug) and temoporfin (lipophilic model drug). All of the lipid vesicular systems, including c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.02.006

    authors： Chen M,Liu X,Fahr A

    更新日期：2011-04-15 00:00:00

  • A fast and reliable DSC-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica.

    abstract：:The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is based on a solvent-free melting/fusion of drug into the MS during a ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.04.035

    authors： Hempel NJ,Brede K,Olesen NE,Genina N,Knopp MM,Löbmann K

    更新日期：2018-06-10 00:00:00

  • Effect of structural factors on release profiles of camptothecin from block copolymer conjugates with high load of drug.

    abstract：:The aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of d-PLA units and poly(ethylene glycol) methyl ether m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.01.022

    authors： Plichta A,Kowalczyk S,Olędzka E,Sobczak M,Strawski M

    更新日期：2018-03-01 00:00:00

  • Synthesis and characterization of hydrogels formed from a glycidyl methacrylate derivative of galactomannan.

    abstract：:The present investigation describes a procedure for the synthesis of a glycidyl methacrylated derivative from galactomannan, GA-MA, and the respective hydrogel formation. The galactomannan (GA), raw material, was purified and dissolved in DMSO. After dissolution, 4-dimethyl-amino-pyridine (DMAP) and glycidyl methacryl...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.08.001

    authors： Reis AV,Cavalcanti OA,Rubira AF,Muniz EC

    更新日期：2003-11-28 00:00:00