当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Water solubilization capacity of pharmaceutical microemulsions based on Peceol®, lecithin and ethanol.

Water solubilization capacity of pharmaceutical microemulsions based on Peceol®, lecithin and ethanol.

Abstract：

:Biocompatible microemulsions composed of Peceol(®), lecithin, ethanol and water developed for encapsulation of hydrophilic drugs were investigated. The binary mixture Peceol(®)/ethanol was studied first. It was shown that the addition of ethanol to pure Peceol(®) has a significant fluidifying and disordering effect on the Peceol(®) supramolecular structure with an enhancement in water solubilization. The water solubilization capacity was improved by adding lecithin as a third component. It was then demonstrated that the ethanol/lecithin weight ratio played an important role in determining the optimal composition in term of water solubilization efficiency, a necessary property for a nutraceutical or pharmaceutical application. The optimal ethanol/lecithin weight ratio in the Peceol(®) rich region was found to be 40/60. Combination different techniques such as SAXS, fluorimetry, rheology and conductivity, we analyzed the water uptake within the microemulsion taking into account the partitioning of ethanol between polar and apolar domains. This ethanol distribution quantified along a water dilution line has a major effect on microemulsion properties.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Mouri A,Diat O,Lerner DA,El Ghzaoui A,Ajovalasit A,Dorandeu C,Maurel JC,Devoisselle JM,Legrand P

doi

10.1016/j.ijpharm.2014.07.018

subject

Has Abstract

pub_date

2014-11-20 00:00:00

pages

324-34

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(14)00517-1

journal_volume

475

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Lysozyme-loaded, electrospun chitosan-based nanofiber mats for wound healing.

    abstract：:In this study, a blend mixture of chitosan-ethylenediaminetetraacetic acid (CS 2 wt%-EDTA) at a weight ratio of 30/70 and polyvinyl alcohol (PVA) solution (10 wt%) was electrospun to produce fibrous mats with lysozyme (10, 20 and 30 wt%) used for wound healing. The morphology and diameter of the electrospun fiber mats...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.02.010

    authors： Charernsriwilaiwat N,Opanasopit P,Rojanarata T,Ngawhirunpat T

    更新日期：2012-05-10 00:00:00

  • Ionic liquids as ingredients in topical drug delivery systems.

    abstract：:Because of their properties, ionic liquids (ILs) (Ranke et al.) offer many advantages in topical drug delivery systems. For example, ionic liquids can be used to increase the solubility of sparingly soluble drugs and to enhance their topical and transdermal delivery. Furthermore, ILs can be used either to synthesize a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.10.035

    authors： Dobler D,Schmidts T,Klingenhöfer I,Runkel F

    更新日期：2013-01-30 00:00:00

  • Acid-base interactions in amorphous solid dispersions of lumefantrine prepared by spray-drying and hot-melt extrusion using X-ray photoelectron spectroscopy.

    abstract：:This study investigates drug-excipient interactions in amorphous solid dispersions (ASDs) of the model basic compound lumefantrine (LMN), with five acidic polymers. X-ray photoelectron spectroscopy (XPS) was used to measure the extent of the protonation of the tertiary amine in LMN by the five acidic polymers. The ext...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.06.126

    authors： Song Y,Zemlyanov D,Chen X,Su Z,Nie H,Lubach JW,Smith D,Byrn S,Pinal R

    更新日期：2016-12-05 00:00:00

  • Design and evaluation of an aerosol infection chamber for small animals.

    abstract：:In this report, we describe the design of an aerosol exposure chamber to reproducibly produce uniformly distributed clouds of droplet nuclei. The device can deliver desired number of bacilli (20-2000) in lungs of mice. All safety measures to handle infectious bacteria have been incorporated in the design and it is con...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00023-1

    authors： Bhaskar S,Upadhyay P

    更新日期：2003-04-14 00:00:00

  • Enhanced bioavailability of tripterine through lipid nanoparticles using broccoli-derived lipids as a carrier material.

    abstract：:Chemotherapy via the oral route remains a considerable challenge due to poor water-solubility and permeability of anticancer agents. This study aimed to construct lipid nanoparticles using broccoli-derived lipids for oral delivery of tripterine (Tri), a natural anticancer candidate, and to enhance its oral bioavailabi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.011

    authors： Li W,Zhang T,Ye Y,Zhang X,Wu B

    更新日期：2015-11-30 00:00:00

  • Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: An in vivo study.

    abstract：:Topical preparations of capsaicin, the major pungent ingredient of hot pepper, are being used for management of pain and inflammatory disorders. Purpose of this study was to use nanoemulsion as an effective topical drug carrier for in vivo delivery of capsaicin. An oil-in-water nanoemulsion containing capsaicin was pr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.043

    authors： Ghiasi Z,Esmaeli F,Aghajani M,Ghazi-Khansari M,Faramarzi MA,Amani A

    更新日期：2019-03-25 00:00:00

  • Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation.

    abstract：:Conventional manufacturing of pharmaceutical tablets often involves single processes such as blending, granulation, milling and direct compression. A process that minimizes and incorporates all these in a single continuous step is desirable. The concept of omitting milling step followed by direct-molding of tablets ut...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.12.053

    authors： Tan DC,Chin WW,Tan EH,Hong S,Gu W,Gokhale R

    更新日期：2014-03-10 00:00:00

  • The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers.

    abstract：:Previous in vivo studies using PEG 400 showed an enhancement in the bioavailability of ranitidine. This study investigated the effect of PEG 200, 300 and 400 on ranitidine transport across Caco-2 cells. The effect of PEG polymers (20%, v/v) on the bi-directional flux of (3)H-ranitidine across Caco-2 cell monolayers wa...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.02.059

    authors： Ashiru-Oredope DA,Patel N,Forbes B,Patel R,Basit AW

    更新日期：2011-05-16 00:00:00

  • Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates.

    abstract：:Oridonin (ORI), a diterpenoid compound with promising antitumor activity, was proved to possess potent antileukemia efficacies in vitro and in vivo recently. However, the development and application of ORI was limited by its poor solubility and rapid plasma clearance. The purpose of this study was to solve these probl...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.08.014

    authors： Shen J,Zhang D,Zhao Z,Jia L,Zheng D,Liu G,Hao L,Zhang Q,Tian X,Li C,Guo H

    更新日期：2013-11-01 00:00:00

  • In vitro biological activity of resveratrol using a novel inhalable resveratrol spray-dried formulation.

    abstract：:The aim of the study was to prepare inhalable resveratrol by spray drying for the treatment of chronic obstructive pulmonary disease (COPD). Resveratrol, with a spherical morphology and particle diameter less than 5 μm, was successfully manufactured. Fine particle fraction (FPF) and mass median aerodynamic diameter (M...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.06.033

    authors： Trotta V,Lee WH,Loo CY,Haghi M,Young PM,Scalia S,Traini D

    更新日期：2015-08-01 00:00:00

  • A simple method for preparation of immuno-magnetic liposomes.

    abstract：:A simple and readily manoeuverable method for preparing immuno-magnetic liposomes that indigenously contain binding sites for attaching other molecules like antibodies on their exterior surface is described. In this method magnetic unilamellar vesicles are prepared from a mixture of phosphatidylcholine, cholesterol, s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00667-0

    authors： Elmi MM,Sarbolouki MN

    更新日期：2001-03-14 00:00:00

  • Secondary structure alterations in insulin and growth hormone water-in-oil emulsions.

    abstract：:Water-in-oil (w/o) emulsions have shown a promising release profile of small drug molecules and proteins. However, the major concerns are the structural stability, the retention of the activity and to avoid unwanted immunological reactions caused by the changes in protein structure. In the present study, the secondary...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00668-3

    authors： Jørgensen L,Vermehren C,Bjerregaard S,Froekjaer S

    更新日期：2003-03-18 00:00:00

  • Can spray freeze-drying improve the re-dispersion of crystalline nanoparticles of pure naproxen?

    abstract：:Spray freeze drying (SFD) was used to prepare re-dispersible powders of crystalline, pure-drug nanodispersions of naproxen in lactose and stabilized with hydroxypropyl cellulose. The particle size of the rehydrated powders was determined using static light scattering/Mie analysis. The nanoparticles present in the SFD ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.04.061

    authors： Braig V,Konnerth C,Peukert W,Lee G

    更新日期：2019-06-10 00:00:00

  • Impact of capsule type on aerodynamic performance of inhalation products: A case study using a formoterol-lactose binary or ternary blend.

    abstract：:The aerodynamic performance of a dry powder for inhalation depends on the formulation and the dry powder inhaler (DPI). In the case of capsule-based DPIs, the capsule also plays a role in the powder aerosolisation and the dispersion of the micronized drug during the inhalation. This study evaluated the impact of gelat...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.10.034

    authors： Wauthoz N,Hennia I,Ecenarro S,Amighi K

    更新日期：2018-12-20 00:00:00

  • A systematic review of the use of dosage form manipulation to obtain required doses to inform use of manipulation in paediatric practice.

    abstract：:This study sought to determine whether there is an evidence base for drug manipulation to obtain the required dose, a common feature of paediatric clinical practice. A systematic review of the data sources, PubMed, EMBASE, CINAHL, IPA and the Cochrane database of systematic reviews, was used. Studies that considered t...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2016.12.032

    authors： Richey RH,Hughes C,Craig JV,Shah UU,Ford JL,Barker CE,Peak M,Nunn AJ,Turner MA

    更新日期：2017-02-25 00:00:00

  • Preparation and characterization of paclitaxel-loaded DSPE-PEG-liquid crystalline nanoparticles (LCNPs) for improved bioavailability.

    abstract：:Lipid-based liquid crystalline nanoparticles (LCNPs) have attracted growing interest as a new drug nanocarrier system for improving bioavailability for both hydrophilic and hydrophobic drugs. In this study, self-assembled LCNPs based on soy phosphatidyl choline and glycerol dioleate, which was known possessing low tox...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.12.058

    authors： Zeng N,Hu Q,Liu Z,Gao X,Hu R,Song Q,Gu G,Xia H,Yao L,Pang Z,Jiang X,Chen J,Fang L

    更新日期：2012-03-15 00:00:00

  • Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action.

    abstract：:This paper examines a perspective to use newly engineered nanomaterials as effective and safe carriers for gene therapy of cancer. Three different groups of cationic dendrimers (PAMAM, phosphorus, and carbosilane) were complexed with anticancer siRNA and the biophysical properties of the dendriplexes created were anal...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.03.034

    authors： Dzmitruk V,Szulc A,Shcharbin D,Janaszewska A,Shcharbina N,Lazniewska J,Novopashina D,Buyanova M,Ionov M,Klajnert-Maculewicz B,Gómez-Ramirez R,Mignani S,Majoral JP,Muñoz-Fernández MA,Bryszewska M

    更新日期：2015-05-15 00:00:00

  • Statistical testing of drug accumulation in skin tissues by linear regression versus contents of stratum corneum lipids.

    abstract：:This investigation is a contribution to standardization in in vitro drug penetration measurements using excised human skin and to statistical treatment of the observations. The wide variations observed in measurements of drug accumulation in and drug permeation through the stratum corneum are caused not only by analyt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00558-5

    authors： Loth H,Hauck G,Borchert D,Theobald F

    更新日期：2000-11-19 00:00:00

  • Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil.

    abstract：:Solid lipid nanoparticles have been reported as possible carrier for skin drug delivery. Solid lipid nanoparticles are produced from biocompatible and biodegradable lipids. Solid lipid nanoparticles made of semi-synthetic triglycerides stabilized with a mixture of polysorbate and sorbitan oleate were loaded with 5% of...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.06.014

    authors： Padois K,Cantiéni C,Bertholle V,Bardel C,Pirot F,Falson F

    更新日期：2011-09-15 00:00:00

  • Alcohol enhanced permeation in model membranes. Part II. Thermodynamic analysis of membrane partitioning.

    abstract：:The role of solvents in drug transport has not been properly addressed in the literature, despite its well known influence on drug permeation. Previously we have conducted thermodynamic and kinetic analyses to probe the molecular mechanisms of alcohol enhanced permeation. In the present study, the influence of tempera...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.08.037

    authors： Oliveira G,Beezer AE,Hadgraft J,Lane ME

    更新日期：2011-11-28 00:00:00

  • Process and formulation characterizations of the thermal adhesion granulation (TAG) process for improving granular properties.

    abstract：:In this study, we demonstrate the feasibility of using the thermal adhesion granulation (TAG) method to improve granular properties for preparing highly compressible excipients as direct tabletting aids. The TAG method subjects a mixture containing excipients, such as microcrystalline cellulose (MCC), lactose, starch,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.02.002

    authors： Lin HL,Ho HO,Chen CC,Yeh TS,Sheu MT

    更新日期：2008-06-05 00:00:00

  • Evaluation of collagen and methylated collagen as gene carriers.

    abstract：:This study explores the potential of DNA complexes prepared with methylated collagen (MC) and unmodified native collagen (NC) to deliver genes into cells. The physicochemical properties and transfection abilities of these two types of complexes are studied in parallel. MC was prepared by methylation of the carboxyl gr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.04.014

    authors： Wang J,Lee IL,Lim WS,Chia SM,Yu H,Leong KW,Mao HQ

    更新日期：2004-07-26 00:00:00

  • Characterization of nifedipine solid dispersions.

    abstract：:The sublingual administration of nifedipine (NIF) is currently used in clinical practice. The sublingual administration of NIF solid dispersions (SD), by using a suitable dispenser, appears an interesting approach in the treatment of moderate and severe hypertensive emergencies. With this aim nine SD made of NIF and a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00173-4

    authors： Cilurzo F,Minghetti P,Casiraghi A,Montanari L

    更新日期：2002-08-21 00:00:00

  • Public engagement workshop: how to improve medicines for older people?

    abstract：:Public engagement in medication management has become more and more important in promoting population health. A public engagement workshop attended by 78 members of the geriatric community, family carers as well as professionals from academic research, industry and regulatory agencies entitled 'How to improve medicine...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.11.024

    authors： Orlu-Gul M,Raimi-Abraham B,Jamieson E,Wei L,Murray M,Stawarz K,Stegemann S,Tuleu C,Smith FJ

    更新日期：2014-01-01 00:00:00

  • New silica nanostructure for the improved delivery of topical antibiotics used in the treatment of staphylococcal cutaneous infections.

    abstract：:In this paper, we report the synthesis, characterization (FT-IR, XRD, BET, HR-TEM) and bioevaluation of a novel γ-aminobutiric acid/silica (noted GABA-SiO₂ or γ-SiO₂) hybrid nanostructure, for the improved release of topical antibiotics, used in the treatment of Staphylococcus aureus infections. GABA-SiO₂ showed IR ba...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.016

    authors： Grumezescu AM,Ghitulica CD,Voicu G,Huang KS,Yang CH,Ficai A,Vasile BS,Grumezescu V,Bleotu C,Chifiriuc MC

    更新日期：2014-03-25 00:00:00

  • Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism.

    abstract：:The present study deals with controlled drug delivery from hydrocolloid tablets by polymer particle erosion. The influence of excipients and formulation factors on the dissolution behaviour of the methyl hydroxyethyl cellulose (MHEC)-tablets is investigated. Linear drug release with low susceptibility to hydrodynamic ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00596-8

    authors： Zuleger S,Lippold BC

    更新日期：2001-04-17 00:00:00

  • The influence of high shear mixing on ternary dry powder inhaler formulations.

    abstract：:The blending process is a key step in the production of dry powder inhaler formulations, but only little is known about the influence of process parameters. This is especially true for high shear blending of ternary formulations. For this reason, this study aims to investigate the influence of high shear mixing proces...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.10.033

    authors： Hertel M,Schwarz E,Kobler M,Hauptstein S,Steckel H,Scherließ R

    更新日期：2017-12-20 00:00:00

  • Ciprofloxacin surf-plexes in sub-micron emulsions: a novel approach to improve payload efficiency and antimicrobial efficacy.

    abstract：:The aim of this study was to investigate antimicrobial efficacy and pharmacokinetic profile of ciprofloxacin (CFn) loaded oil-in-water (o/w) submicron emulsion (SE-CFn). This study emphasized on development of hydrophobic ion-pair complexes of CFn with sodium deoxycholate (SDC) [CFn-SDC], which was incorporated in the...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.02.020

    authors： Jain V,Singodia D,Gupta GK,Garg D,Keshava GB,Shukla R,Shukla PK,Mishra PR

    更新日期：2011-05-16 00:00:00

  • Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method.

    abstract：:Sustained-release nitrendipine microspheres were prepared in liquid system by quasi-emulsion solvent diffusion method, in which the Aerosil was employed as an inert dispersing carrier to improve the dissolution rate of nitrendipine, and Eudragit RS as a retarding agent to control the release rate. The resultant micros...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00209-6

    authors： Yang Ms,Cui Fd,You Bg,Fan Yl,Wang L,Yue P,Yang H

    更新日期：2003-06-18 00:00:00

  • Effects of carriers on transgene expression from plasmids containing a DNA sequence with high histone affinity.

    abstract：:The intranuclear disposition of plasmid DNA is highly important for transgene expression. The effects of a left-handedly curved sequence with high histone affinity on transgene expression were examined in COS-7 cells with two kinds of carriers (Lipofectamine Plus and TransIT-LT1). Three plasmids containing the curved ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.04.032

    authors： Kamiya H,Fukunaga S,Ohyama T,Harashima H

    更新日期：2009-07-06 00:00:00