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Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil.

Abstract：

:Solid lipid nanoparticles have been reported as possible carrier for skin drug delivery. Solid lipid nanoparticles are produced from biocompatible and biodegradable lipids. Solid lipid nanoparticles made of semi-synthetic triglycerides stabilized with a mixture of polysorbate and sorbitan oleate were loaded with 5% of minoxidil. The prepared systems were characterized for particle size, pH and drug content. Ex vivo skin penetration studies were performed using Franz-type glass diffusion cells and pig ear skin. Ex vivo skin corrosion studies were realized with a method derived from the Corrositex(®) test. Solid lipid nanoparticles suspensions were compared to commercial solutions in terms of skin penetration and skin corrosion. Solid lipid nanoparticles suspensions have been shown as efficient as commercial solutions for skin penetration; and were non-corrosive while commercial solutions presented a corrosive potential. Solid lipid nanoparticles suspensions would constitute a promising formulation for hair loss treatment.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Padois K,Cantiéni C,Bertholle V,Bardel C,Pirot F,Falson F

doi

10.1016/j.ijpharm.2011.06.014

subject

Has Abstract

pub_date

2011-09-15 00:00:00

pages

300-4

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(11)00548-5

journal_volume

416

pub_type

杂志文章

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