Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method.


:Sustained-release nitrendipine microspheres were prepared in liquid system by quasi-emulsion solvent diffusion method, in which the Aerosil was employed as an inert dispersing carrier to improve the dissolution rate of nitrendipine, and Eudragit RS as a retarding agent to control the release rate. The resultant microspheres were evaluated for the recovery, bulk density, average particle size, drug loading, and incorporation efficiency. And the factors affecting the formation of microspheres and the drug-release rate were investigated. It was observed by a scanning electron microscope (SEM) that the microspheres were finely spherical and uniform, and no entire nitrendipine crystals were observed visually. The results of X-ray diffraction indicated that nitrendipine in microspheres was disordered, suggesting that nitrendipine was highly dispersed in microspheres. The drug loading of microspheres was enhanced with increasing the ratio of drug to excipients, and the incorporation efficiency was always >90%. The formation of microspheres was mainly influenced by the amount of bridging liquid and sodium dodecyl sulfate (SDS) in poor solvent. The dissolution profiles could be modulated with adjusting the amount of retarding agent and dispersing carrier formulated.


Int J Pharm


Yang Ms,Cui Fd,You Bg,Fan Yl,Wang L,Yue P,Yang H





Has Abstract


2003-06-18 00:00:00














  • MiRNA-204-5p and oxaliplatin-loaded silica nanoparticles for enhanced tumor suppression effect in CD44-overexpressed colon adenocarcinoma.

    abstract::Main purpose of present study was to enhance the therapeutic efficacy in the treatment of colon adenocarcinoma by combining the benefits of chemotherapy and gene therapy. In this study, we have successfully formulated oxaliplatin (OXL) and miRNA-204-5p loaded polyethyleneimine (PEI)/hyaluronic acid (HA)-assembled meso...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Yang H,Liu Y,Qiu Y,Ding M,Zhang Y

    更新日期:2019-07-20 00:00:00

  • One-pot synthesis of dopamine-conjugated hyaluronic acid/polydopamine nanocomplexes to control protein drug release.

    abstract::The self-organizing complexes with hyaluronic acid (HA) and polydopamine (PDA), an adhesion mediator via hydrogen bonding, were investigated for use as protein drug carriers. The complexes were prepared with HA of different molecular weights (20 kDa and 200 kDa) and various molar ratios of dopamine and lysozyme, a mod...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Lim DG,Prim RE,Kang E,Jeong SH

    更新日期:2018-05-05 00:00:00

  • Sustained intrathecal therapeutic protein delivery using genetically transduced tissue implants in a freely moving rat model.

    abstract::Systemic delivery of therapeutic proteins to the central nervous system (CNS) is challenging because of the blood-brain barrier restrictions. Direct intrathecal delivery is possible but does not produce stable concentrations. We are proposing an alternative approach for localized delivery into the CNS based on the Tra...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Aronson JP,Katnani HA,Pomerantseva I,Shapir N,Tse H,Miari R,Goltsman H,Mwizerwa O,Neville CM,Neil GA,Eskandar EN,Sundback CA

    更新日期:2017-12-20 00:00:00

  • Risperidone solid dispersion for orally disintegrating tablet: its formulation design and non-destructive methods of evaluation.

    abstract::The focus of present investigation was to assess the utility of non-destructive techniques in the evaluation of risperidone solid dispersions (SD) with methyl-β-cyclodextrin (MBCD) and subsequent incorporation of the SD into orally disintegrating tablets (ODT) for a faster release of risperidone. The SD was prepared b...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Rahman Z,Zidan AS,Khan MA

    更新日期:2010-11-15 00:00:00

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    abstract::Moisture-sensitive pseudo-polymorphs with different stabilities were characterized, and their polymorphisms were monitored in the process of tableting and film coating by near-infrared (NIR) spectroscopy. In this study, we proved that we could successfully maintain the crystal form ratio in the tablet by controlling t...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kamada K,Yoshimura S,Murata M,Murata H,Nagai H,Ushio H,Terada K

    更新日期:2009-02-23 00:00:00

  • Influence of dissolution medium buffer composition on ketoprofen release from ER products and in vitro-in vivo correlation.

    abstract::The purpose of this work was to investigate the influence of dissolution medium composition on the in vitro release of ketoprofen from a series of ER products and the impact of the different buffer media on the in vivo-in vitro (IVIV) relationship. The products investigated were coated micro bead preparations having i...

    journal_title:International journal of pharmaceutics

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    authors: Corrigan OI,Devlin Y,Butler J

    更新日期:2003-03-26 00:00:00

  • Novel fenofibric acid-loaded controlled release pellet bioequivalent to choline fenofibrate-loaded commercial product in beagle dogs.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kim KS,Jin SG,Mustapha O,Yousaf AM,Kim DW,Kim YH,Kim JO,Yong CS,Woo JS,Choi HG

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  • Behavior of uptake of moisture by drugs and excipients under accelerated conditions of temperature and humidity in the absence and the presence of light. 1. Pure anti-tuberculosis drugs and their combinations.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Singh S,Bhutani H,Mariappan TT,Kaur H,Bajaj M,Pakhale S

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  • Prevention of influenza virus infection and transmission by intranasal administration of a porous maltodextrin nanoparticle-formulated vaccine.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Quan Le M,Ye L,Bernasconi V,Carpentier R,Fasquelle F,Lycke N,Staeheli P,Betbeder D

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Tsutsumi K,Obata Y,Takayama K,Isowa K,Nagai T

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    journal_title:International journal of pharmaceutics

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    authors: Buttini F,Miozzi M,Balducci AG,Royall PG,Brambilla G,Colombo P,Bettini R,Forbes B

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: de Jalón EG,Blanco-Príeto MJ,Ygartua P,Santoyo S

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    authors: Giry K,Péan JM,Giraud L,Marsas S,Rolland H,Wüthrich P

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    authors: van der Heijden I,Beijnen JH,Nuijen B

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Maier T,Scheuerle RL,Markl D,Bruggraber S,Zeitler A,Fruk L,Slater NKH

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    pub_type: 杂志文章


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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Maafi W,Maafi M

    更新日期:2013-11-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2014-01-30 00:00:00

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    pub_type: 杂志文章


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    更新日期:2020-03-30 00:00:00

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    pub_type: 杂志文章


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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Wu JX,Xia D,van den Berg F,Amigo JM,Rades T,Yang M,Rantanen J

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2015-12-30 00:00:00