Abstract：
:Sustained-release nitrendipine microspheres were prepared in liquid system by quasi-emulsion solvent diffusion method, in which the Aerosil was employed as an inert dispersing carrier to improve the dissolution rate of nitrendipine, and Eudragit RS as a retarding agent to control the release rate. The resultant microspheres were evaluated for the recovery, bulk density, average particle size, drug loading, and incorporation efficiency. And the factors affecting the formation of microspheres and the drug-release rate were investigated. It was observed by a scanning electron microscope (SEM) that the microspheres were finely spherical and uniform, and no entire nitrendipine crystals were observed visually. The results of X-ray diffraction indicated that nitrendipine in microspheres was disordered, suggesting that nitrendipine was highly dispersed in microspheres. The drug loading of microspheres was enhanced with increasing the ratio of drug to excipients, and the incorporation efficiency was always >90%. The formation of microspheres was mainly influenced by the amount of bridging liquid and sodium dodecyl sulfate (SDS) in poor solvent. The dissolution profiles could be modulated with adjusting the amount of retarding agent and dispersing carrier formulated.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Yang Ms,Cui Fd,You Bg,Fan Yl,Wang L,Yue P,Yang Hdoi
10.1016/s0378-5173(03)00209-6keywords:
subject
Has Abstractpub_date
2003-06-18 00:00:00pages
103-13issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517303002096journal_volume
259pub_type
杂志文章abstract：:It has been clearly demonstrated that ultraviolet radiation is harmful to the skin and can cause helioderma and cancers. There are different methods of combating ultraviolet radiation: sunscreens formulated with filters and/or screens as well as clothing. For this work, the authors studied different fabrics to evaluat...
journal_title：International journal of pharmaceutics
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
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pub_type： 杂志文章,评审
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：1999-04-15 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2020-09-25 00:00:00
