当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Establishing and analyzing the design space in the development of direct compression formulations by gene expression programming.

Establishing and analyzing the design space in the development of direct compression formulations by gene expression programming.

Abstract：

PURPOSE:In this paper we have evaluated the gene expression programming (GEP) methodology for modeling the effect of different variables (continuous and nominal) and their interactions on the properties of direct compression formulations. METHODS:The effect of four variables was studied; variety of diluents, type and percentage of drug and maximum compression force, on the mechanical and drug release properties of direct compression tablets. The generated database (36 formulations) was used for mathematical and GEP modeling. RESULTS:GEP has been shown to have a high accuracy in prediction for four out five outputs studied including friability which had no replicate measurements. Compared to the traditional statistical treatment GEP is less time consuming and gives equations which are extremely helpful in understanding the interactions of the different variables and for establishing the design space in the development of direct compression formulations. CONCLUSIONS:GEP allows similar conclusions than traditional statistical treatment. The helpfulness of this methodology in establishing the design space has been demonstrated. The knowledge derived from GEP can easily be increased by including additional information or new inputs, such as additional drugs or combinations of excipients in the data set.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Landin M,Rowe RC,York P

doi

10.1016/j.ijpharm.2012.04.078

subject

Has Abstract

pub_date

2012-09-15 00:00:00

pages

35-42

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(12)00454-1

journal_volume

434

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Physicochemical and biopharmaceutical characterization of BTA-243, a diacidic drug with low oral bioavailability.

    abstract：:This investigation has examined possible causes of the poor bioavailability of the beta(3)-adrenoceptor agonist BTA-243. The aqueous solubility of BTA-243 is pH dependent with a solubility minimum at pH 1.5. However, the dissolution rate of the disodium salt of BTA-243 is similar at both pH 2.0 and 7.4 indicating that...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00657-8

    authors： Brown JR,Collett JH,Attwood D,Ley RW,Sims EE

    更新日期：2001-02-01 00:00:00

  • Simultaneous optimization of percutaneous delivery and adhesion for ketoprofen poultice.

    abstract：:Topical poultices of ketoprofen were prepared using deionized water, propylene glycol (X1), and glycerin (X2) as the vehicle in combination with hydrophilic matrix materials, including gelatin (X3) and sodium polyacrylate. A mixture design was utilized to evaluate the influence of these constituents (X1-X3) on the adh...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00919-x

    authors： Sheu MT,Chen LC,Ho HO

    更新日期：2002-02-21 00:00:00

  • MiRNA-204-5p and oxaliplatin-loaded silica nanoparticles for enhanced tumor suppression effect in CD44-overexpressed colon adenocarcinoma.

    abstract：:Main purpose of present study was to enhance the therapeutic efficacy in the treatment of colon adenocarcinoma by combining the benefits of chemotherapy and gene therapy. In this study, we have successfully formulated oxaliplatin (OXL) and miRNA-204-5p loaded polyethyleneimine (PEI)/hyaluronic acid (HA)-assembled meso...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.06.020

    authors： Yang H,Liu Y,Qiu Y,Ding M,Zhang Y

    更新日期：2019-07-20 00:00:00

  • Development of a PAT tool for monitoring the Wurster coater performance.

    abstract：:Real-time process analytical technology (PAT) is proposed as an effective approach for monitoring the performance of a Wurster coater. The coater was used for coating of 0.78 mm pharmaceutical pellets. The coating solution consisted of Hydroxypropyl methylcellulose/Poly ethylene glycol. During the coating process, sma...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.02.023

    authors： Foroughi-Dahr M,Sotudeh-Gharebagh R,Mostoufi N

    更新日期：2019-04-20 00:00:00

  • Enhanced oral delivery of alendronate by sucrose fatty acids esters in rats and their absorption-enhancing mechanisms.

    abstract：:Oral delivery is the most fascinating route for interminable drug remedy. However, the intestinal absorption of alendronate (ALN), a bisphosphonate drug after oral administration is very poor. Absorption enhancers, which help to achieve the efficiency-safety balance, are considered one of the most promising agents for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.10.046

    authors： Alama T,Katayama H,Hirai S,Ono S,Kajiyama A,Kusamori K,Katsumi H,Sakane T,Yamamoto A

    更新日期：2016-12-30 00:00:00

  • Nanodiamonds: Minuscule gems that ferry antineoplastic drugs to resistant tumors.

    abstract：:Remarkable efforts are currently devoted to the area of nanodiamonds (NDs) research due to their superior properties viz: biocompatibility, minute size, inert core, and tunable surface chemistry. The use of NDs for the delivery of anticancer drugs has been at the forefront of NDs applications owing to their ability to...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2018.12.090

    authors： Ali MS,Metwally AA,Fahmy RH,Osman R

    更新日期：2019-03-10 00:00:00

  • Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice.

    abstract：:The purpose of this study was to characterize the in vitro properties of a number of chitosan-based microemulsions containing nobiletin and determine its distribution in mice brain following i.v. administration. The phase behavior and properties of chitosan-based microemulsions were investigated in a pseudo-ternary sy...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.10.010

    authors： Yao J,Zhou JP,Ping QN,Lu Y,Chen L

    更新日期：2008-03-20 00:00:00

  • Application of continuous twin screw granulation for the metformin hydrochloride extended release formulation.

    abstract：:This study focuses on evaluating the potential of transferring from a batch process to continuous process for manufacturing of the extended release formulation. Metformin hydrochloride (HCl) was used in the model formulation which was intended to contain the high amount of hydrophilic drug. The effects of barrel tempe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.07.019

    authors： Kim SH,Hwang KM,Cho CH,Nguyen TT,Seok SH,Hwang KM,Kim JY,Park CW,Rhee YS,Park ES

    更新日期：2017-08-30 00:00:00

  • Optimized conditions of bio-mimetic artificial membrane permeation assay.

    abstract：:Effects of pH and co-solvents on the bio-mimetic artificial membrane permeation assay were investigated to determine the optimal conditions for the prediction of oral absorption. The permeability (P(am)) of 33 structurally diverse drugs to the PC/PE/PS/PI/CHO/1,7-octadiene membrane system (bio-mimetic lipid (BML) memb...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00845-6

    authors： Sugano K,Hamada H,Machida M,Ushio H,Saitoh K,Terada K

    更新日期：2001-10-09 00:00:00

  • Controllable encapsulation of α-mangostin with quaternized β-cyclodextrin grafted chitosan using high shear mixing.

    abstract：:In this study, the inclusion complex formation between α-mangostin and water-soluble quaternized β-CD grafted-chitosan (QCD-g-CS) was investigated. Inclusion complex formation with encapsulation efficiency (%EE) of 5, 15 and 75% can be varied using high speed homogenizer. Tuning %EE plays a role on physicochemical and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.12.016

    authors： Phunpee S,Suktham K,Surassmo S,Jarussophon S,Rungnim C,Soottitantawat A,Puttipipatkhachorn S,Ruktanonchai UR

    更新日期：2018-03-01 00:00:00

  • Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate.

    abstract：:Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) and it is mainly administered either orally or by subcutaneous (SC) injection, which are not so satisfactory. While orally administered MTX is associated with variable bioavailability and cause...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119580

    authors： Tekko IA,Chen G,Domínguez-Robles J,Thakur RRS,Hamdan IMN,Vora L,Larrañeta E,McElnay JC,McCarthy HO,Rooney M,Donnelly RF

    更新日期：2020-08-30 00:00:00

  • Improving matrix metalloproteinase-2 specific response of a hydrogel system using electrophoresis.

    abstract：:Matrix metalloproteinases (MMPs) overexpression plays a critical role in cancer invasion and metastasis. We utilized this key feature of tumor microenvironment to develop a disease-stimuli triggered drug delivery system. Poly(acrylic acid) hydrogels were synthesized by UV polymerization and pendant MMP-2 sensitive pep...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.012

    authors： Zhang Y,Gemeinhart RA

    更新日期：2012-06-15 00:00:00

  • Prediction of drug-packaging interactions via molecular dynamics (MD) simulations.

    abstract：:The interaction between packaging materials and drug products is an important issue for the pharmaceutical industry, since during manufacturing, processing and storage a drug product is continuously exposed to various packaging materials. The experimental investigation of a great variety of different packaging materia...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.049

    authors： Feenstra P,Brunsteiner M,Khinast J

    更新日期：2012-07-15 00:00:00

  • Pharmaceutical grade phyllosilicate dispersions: the influence of shear history on floc structure.

    abstract：:The effect of mixing conditions on the flow curves of some clay-water dispersions was studied. Two Spanish fibrous phyllosilicates (sepiolite from Vicálvaro and palygorskite from Turón) and a commercial bentonite (Bentopharm Copyright, UK) were selected as model clays. The disperse systems were made up using a rotor-s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00075-7

    authors： Viseras C,Meeten GH,Lopez-Galindo A

    更新日期：1999-05-10 00:00:00

  • The progress on sulfhydryl modified polymers with regard to synthesis, characterization and mucoadhesion.

    abstract：:The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients underwent chemical modification with sulfhydryl groups on the polymeric backbone so ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2020.120016

    authors： Sanchez Armengol E,Laffleur F

    更新日期：2021-01-05 00:00:00

  • New amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp.

    abstract：:Amphotericin B (AmB) has a broad antifungal and leishmanicidal activity with low incidence of clinical resistance. Its parenteral administration has high risk of nephrotoxicity that limits its use. In order to treat cutaneous infections, AmB topical administration is a safer therapy because of the low systemic absorpt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.07.004

    authors： Ruiz HK,Serrano DR,Dea-Ayuela MA,Bilbao-Ramos PE,Bolás-Fernández F,Torrado JJ,Molero G

    更新日期：2014-10-01 00:00:00

  • Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin.

    abstract：:As with many other anti-cancer agents, docetaxel is a substrate for ATP-binding cassette transporters such as P-glycoprotein and its metabolism is mainly catalysed by CYP3A. In order to improve the oral bioavailability of docetaxel, a component of turmeric, curcumin, which can down-regulate the intestinal P-glycoprote...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.08.015

    authors： Yan YD,Kim DH,Sung JH,Yong CS,Choi HG

    更新日期：2010-10-31 00:00:00

  • Statistical testing of drug accumulation in skin tissues by linear regression versus contents of stratum corneum lipids.

    abstract：:This investigation is a contribution to standardization in in vitro drug penetration measurements using excised human skin and to statistical treatment of the observations. The wide variations observed in measurements of drug accumulation in and drug permeation through the stratum corneum are caused not only by analyt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00558-5

    authors： Loth H,Hauck G,Borchert D,Theobald F

    更新日期：2000-11-19 00:00:00

  • Formulation characteristics and in vitro release testing of cyclosporine ophthalmic ointments.

    abstract：:The aim of the present study was to investigate the relationship between formulation/process variables versus the critical quality attributes (CQAs) of cyclosporine ophthalmic ointments and to explore the feasibility of using an in vitro approach to assess product sameness. A definitive screening design (DSD) was used...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.04.042

    authors： Dong Y,Qu H,Pavurala N,Wang J,Sekar V,Martinez MN,Fahmy R,Ashraf M,Cruz CN,Xu X

    更新日期：2018-06-10 00:00:00

  • Development of novel topical tranexamic acid liposome formulations.

    abstract：:The aims of this study were to develop novel liposome formulations for tranexamic acid (TA) from various lipid compositions [neutral (hydrogenated soya phosphatidylcholine and cholesterol), positive (stearylamine) or negative (dicetyl phosphate) charged lipid], and to investigate the effects of concentrations of TA (5...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00980-2

    authors： Manosroi A,Podjanasoonthon K,Manosroi J

    更新日期：2002-03-20 00:00:00

  • Recent advances in local drug delivery to the inner ear.

    abstract：:Inner ear diseases are not adequately treated by systemic drug administration mainly because of the blood-perilymph barrier that reduces exchanges between plasma and inner ear fluids. Local drug delivery methods including intratympanic and intracochlear administrations are currently developed to treat inner ear disord...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2015.08.015

    authors： El Kechai N,Agnely F,Mamelle E,Nguyen Y,Ferrary E,Bochot A

    更新日期：2015-10-15 00:00:00

  • Improving long circulation and procoagulant platelet targeting by engineering of hirudin prodrug.

    abstract：:To reduce systemic bleeding risks during anticoagulant treatment, a new concept named "precise anticoagulation" was proposed to localize the effects of anticoagulants via the targeted delivery of prodrugs to the coagulation site. In this study, the fusion protein Annexin V-hirudin 3-ABD (hAvHA) was constructed to achi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119869

    authors： Han HH,Zhang HT,Wang R,Yan Y,Liu X,Wang Y,Zhu Y,Wang JC

    更新日期：2020-09-10 00:00:00

  • Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport.

    abstract：:The majority of innovative drug candidates are poorly water soluble and exhibit basic properties. This makes them highly dependent on the in vivo encountered acid-neutral pH sequence to achieve a sufficient dissolution and thus absorption. In this study, we evaluated the pH-independent generation of intraluminally ind...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.049

    authors： Mellaerts R,Mols R,Kayaert P,Annaert P,Van Humbeeck J,Van den Mooter G,Martens JA,Augustijns P

    更新日期：2008-06-05 00:00:00

  • Preparation of cyclosporine A nanoparticles by evaporative precipitation into aqueous solution.

    abstract：:Amorphous nanoparticle suspensions of a poorly water-soluble drug, cyclosporine A, are produced by a new process, evaporative precipitation into aqueous solution (EPAS). The rapid evaporation of a heated organic solution of the drug, which is atomized into an aqueous solution, results in fast nucleation leading to nan...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00147-3

    authors： Chen X,Young TJ,Sarkari M,Williams RO 3rd,Johnston KP

    更新日期：2002-08-21 00:00:00

  • Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole.

    abstract：:Electrospun composite zein/eudragit nanofibers were developed with an aim to deliver two different classes of drugs simultaneously that would restrict/compensate the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs). Co-administration of proton pump inhibitors is beneficial for patients consuming NSAID...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.075

    authors： Karthikeyan K,Guhathakarta S,Rajaram R,Korrapati PS

    更新日期：2012-11-15 00:00:00

  • In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery.

    abstract：:Cell-based and acute and subchronic in vivo toxicity profiles of a dendrimer based on melamine reveal that this class of molecules warrants additional study as vehicles for drug delivery. In cell culture, a substantial decrease in viability was observed at 0.1 mg/mL. For the acute studies, mice were administered 2.5, ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2004.04.023

    authors： Neerman MF,Zhang W,Parrish AR,Simanek EE

    更新日期：2004-08-20 00:00:00

  • Application of artificial neural networks (ANNs) and genetic programming (GP) for prediction of drug release from solid lipid matrices.

    abstract：:The aim of the present study was to develop a semi-empirical mathematical model, which is able to predict the release profiles of solid lipid extrudates of different dimensions. The development of the model was based on the application of ANNs and GP. ANNs' abilities to deal with multidimensional data were exploited. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.05.021

    authors： Güres S,Mendyk A,Jachowicz R,Dorożyński P,Kleinebudde P

    更新日期：2012-10-15 00:00:00

  • Calorimetric study of bovine serum albumin dilution and adsorption onto polystyrene particles.

    abstract：:Titration calorimetry was used to investigate the interaction between a model antigen, bovine serum albumin (BSA), and a model particulate carrier, polystyrene (PS). The binding enthalpy was much higher than reported in the literature for a similar system and did not display a sigmoidal binding curve. These experiment...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.02.037

    authors： Pollitt MJ,Buckton G,Brocchini S,Alpar HO

    更新日期：2005-07-25 00:00:00

  • Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform.

    abstract：:Paclitaxel, a potential anticancer agent against solid tumors has been restricted from its oral use due to poor water solubility as well as Pgp efflux property. The present study was aimed to improve the oral bioavailability of paclitaxel through development of (o/w) nanoemulsion consisting of Capryol 90 as internal p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.10.055

    authors： Choudhury H,Gorain B,Karmakar S,Biswas E,Dey G,Barik R,Mandal M,Pal TK

    更新日期：2014-01-02 00:00:00

  • Study on jelly fig extract as a potential hydrophilic matrix for controlled drug delivery.

    abstract：:The principal component of aqueous extract of jelly fig (Ficus awkeotsang Makino) seeds is a pectin-type polysaccharide, gelling even at room temperature without adding any sugars, acids or ions. The objective of this study was to evaluate jelly fig extract (JF) as a matrix base for sustained release tablets. Drug rel...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.08.023

    authors： Miyazaki Y,Yakou S,Takayama K

    更新日期：2004-12-09 00:00:00