Abstract：
:Pharmacopoeias prescribe tests to determine the levels of arsenic in raw materials and glass containers. In this study, glass ampoules for injectables containing individually the main components of intravenous nutrition formulations were submitted to the hydrolytic resistance test by heating at 121 degrees C for 30 min. As(V) and As(III) levels in these solutions after heating were determined by hydride generation atomic absorption spectrometry. The arsenic content of substances used in these formulations was previously determined, as well as the arsenic content of the glass containers. The results showed that raw substances as well as glass containers contain arsenic. Moreover, arsenic is released during the heating (hydrolytic resistance test). However, the amount released and the arsenic species present in solution depend on the solution composition. While As(V) was the predominant specie in glass, solutions containing reducing substances such as glucose and vitamins had As(III) in higher concentration. Therefore, arsenic is released from glass containers during the heating for sterilization, and reacts with formulation constituents depending on their reducing properties.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Bohrer D,Becker E,Nascimento PC,Mörschbächer V,de Carvalho LM,da Silva Marques Mdoi
10.1016/j.ijpharm.2006.02.008subject
Has Abstractpub_date
2006-06-06 00:00:00pages
24-9issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(06)00112-8journal_volume
315pub_type
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