Abstract：
:Viscous liquid degradable polymers have advantages as drug depots for sustained protein delivery. We have created a new aliphatic polycarbonate for this purpose, poly(trimethylene carbonate-co-5-hydroxy trimethylene carbonate), which upon degradation retains a near neutral micro-environmental pH. As such, this copolymer is highly suited to the delivery of acid sensitive proteins. We show that the mechanism of protein release from this liquid copolymer is consistent with the formation of super-hydrated regions as a result of the osmotic activity of the solution formed upon distributed protein particle dissolution. Protein release can be manipulated by controlling polymer hydrophobicity which can be adjusted by molecular weight and choice of initiator. Moreover, protein release is highly dependent on protein solubility which impacts the osmotic activity of the solution formed upon dissolution of the protein particles while protein molecular size and isoelectric point are not as influential. As demonstrated by the release of highly bioactive vascular endothelial growth factor, formulations of this copolymer are suitable for prolonged delivery of protein therapeutics.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Mohajeri S,Burke-Kleinman J,Maurice DH,Amsden BGdoi
10.1016/j.ijpharm.2020.119965subject
Has Abstractpub_date
2020-11-30 00:00:00pages
119965eissn
0378-5173issn
1873-3476pii
S0378-5173(20)30950-9journal_volume
590pub_type
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