Abstract:
:A series of new, low molecular mass, lysine-based peptide dendrimers with varying distribution of cationic and aromatic groups in the structure were synthesized. They expressed antimicrobial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria as well as against fungal pathogens (Candida albicans). Their cytotoxic, haematotoxic, and genotoxic effects were studied. It appears that degree of branching and steric distribution and types of hydrophobic (aromatic) groups and cationic centres are important components of dendrimeric structure and influence both antimicrobial potency and toxicity. Such 3D structure of our dendrimers mimics that of the natural antimicrobial peptides and can be achieved by application of dendrimer chemistry.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Klajnert B,Janiszewska J,Urbanczyk-Lipkowska Z,Bryszewska M,Shcharbin D,Labieniec Mdoi
10.1016/j.ijpharm.2005.10.039keywords:
subject
Has Abstractpub_date
2006-02-17 00:00:00pages
208-17issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(05)00756-8journal_volume
309pub_type
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