Abstract：
:The effect of different preparation parameters were analyzed with respect to the rheological and pharmaceutical characteristics of hydrogel blend patches, as transdermal delivery formulation. Mixtures of pectin and gelatin were employed for the production of patches, with adjustable properties, following a two-step gelation procedure. The first gelation, a thermal one, is trigged by the presence of gelatin, whereas, the second gelation, an ionic one, is due to the formation of the typical egg box structure of pectin. In particular, the patch structural properties were assessed by oscillation stress sweep measurements which provided information concerning their viscolelastic properties. In addition, different modalities for drug loading were analyzed with respect to drug homogeneous distribution; testosterone was employed as model drug for transdermal administration. Finally, the performances of the produced transdermal patches were studied, in term of reproducibility and reliability, by determination of in vitro drug release profiles.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Mazzitelli S,Pagano C,Giusepponi D,Nastruzzi C,Perioli Ldoi
10.1016/j.ijpharm.2013.06.081subject
Has Abstractpub_date
2013-09-15 00:00:00pages
47-57issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(13)00601-7journal_volume
454pub_type
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