Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.

abstract：:The aim of this study was to investigate the feasibility of the transdermal delivery of catechins and caffeine from green tea extract. Drug-in-adhesive patches containing 1.35, 1.03, 0.68, and 0.32 mg cm(-2) green tea extract were formulated and the dissolution of (-)-epigallocatechin gallate (EGCg), (-)-epigallocatec...

journal_title：International journal of pharmaceutics

authors： Batchelder RJ,Calder RJ,Thomas CP,Heard CM

更新日期：2004-09-28 00:00:00

abstract：:The aim of the present work was to study the influence of surface hydrophilicity of biodegradable polymeric nanoparticles on cellular uptake by Caco-2 cells. Poly(D,L-lactide-co-glycolide acid) particles loaded with a fluorescent dye, 3,3'-dioctadecyloxacarbo-cyanine perchlorate (DiO), were prepared by the emulsion-ev...

journal_title：International journal of pharmaceutics

authors： Gaumet M,Gurny R,Delie F

更新日期：2010-05-05 00:00:00

abstract：:Isoniazid (INH) is a first-line therapy for bone tuberculosis (TB), but its clinic benefits are limited by severe side-effects after long-time administration. While nano-drug delivery systems present as promising strategies for INH delivery, the therapeutic efficacies are usually suboptimal due to ineffective drug acc...

journal_title：International journal of pharmaceutics

authors： Liu P,Guo B,Wang S,Ding J,Zhou W

更新日期：2019-03-10 00:00:00

abstract：:In current study, a self-nanoemulsifying drug delivery system (SNEDDS) of persimmon (Diospyros kaki) leaf extract (PLE) was developed and characterized to compare its in vitro dissolution and relative bioavailability with commercially available tablets (Naoxinqing tablets). Pseudo-ternary phase diagrams were construct...

journal_title：International journal of pharmaceutics

authors： Li W,Yi S,Wang Z,Chen S,Xin S,Xie J,Zhao C

更新日期：2011-11-25 00:00:00

abstract：:Although parabens have several features of ideal preservatives, different studies have shown that they may affect human health due to their estrogenic activity. Therefore, various strategies have been applied to reduce their skin penetration. However, the effect of paraben combinations on transdermal permeation has no...

journal_title：International journal of pharmaceutics

authors： Caon T,Costa AC,de Oliveira MA,Micke GA,Simões CM

更新日期：2010-05-31 00:00:00

abstract：:Along with the malignant proliferation of tumor requiring nutrients, the expression of L-type amino acid transporter 1(LAT1) and amino acid transporter B0,+ (ATB0,+) in cancer cells is up-regulated that can be used as new targets for active targeting of tumor. However, since normal cells also express amino acid transp...

journal_title：International journal of pharmaceutics

authors： Wang Z,Lin X,Chi D,Xu Z,Lin G,Liu H,Sun J,He Z,Wang Y

更新日期：2020-09-25 00:00:00

abstract：:The aim of this study was to provide preliminary validation of a new sublingual mucosal cell line (HO-1-u-1) for use as in vitro sublingual drug delivery screening of compounds involving passive diffusion. HO-1-u-1 cells were seeded on cell culture inserts. The ultrastructure and integrity of cell layers, inter-passag...

journal_title：International journal of pharmaceutics

authors： Wang Y,Zuo Z,Lee KK,Chow MS

更新日期：2007-04-04 00:00:00

abstract：:As the number of pharmaceutical candidate compounds increases, so does the need for development workflow that is capable of handling more compounds in shorter times. In this paper, the establishment of a high-throughput automated powder compatibility testing system is reported. The integrated robotic system automatica...

journal_title：International journal of pharmaceutics

authors： Wakasawa T,Sano K,Hirakura Y,Toyo'oka T,Kitamura S

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:In this paper we have evaluated the gene expression programming (GEP) methodology for modeling the effect of different variables (continuous and nominal) and their interactions on the properties of direct compression formulations. METHODS:The effect of four variables was studied; variety of diluents, type and ...

journal_title：International journal of pharmaceutics

authors： Landin M,Rowe RC,York P

更新日期：2012-09-15 00:00:00

abstract：:Supra Molecular Biovectors (SMBV) are nanoparticles composed by a polysaccharidic core surrounded by a lipid bilayer. They are designed for drug delivery and vaccine and can be administrated by nasal route. The association rate and the stability of association between active principle (AP) or antigens (Ag) with SMBV c...

journal_title：International journal of pharmaceutics

authors： Siguier JP,Major M,Balland O

更新日期：2002-08-21 00:00:00

abstract：:Rhenium-188 labeled tin (Sn) microparticles were developed for pain palliation therapy in the patients suffering from synovitis with acute pain. The rhenium tin microparticles were prepared using stannous chloride and freshly eluted (188)ReO(4)(-) from (188)W/(188)Re generator. The aggregated colloidal particles, pack...

journal_title：International journal of pharmaceutics

authors： Shukla J,Bandopadhyaya GP,Shamim SA,Kumar R

更新日期：2007-06-29 00:00:00

abstract：:Metformin has several problems such as low bioavailability, short half-life, and narrow absorption window, sustained and site-specific drug delivery system is required. Floating drug delivery systems are very useful to achieve these purposes. However, conventional floating systems have several limitations; lag time, a...

journal_title：International journal of pharmaceutics

authors： Wook Huh H,Na YG,Kang H,Kim M,Han M,Mai Anh Pham T,Lee H,Baek JS,Lee HK,Cho CW

更新日期：2021-01-05 00:00:00

abstract：:A comprehensive model is proposed to accurately describe drug release kinetics from a coated plane sheet when drug loading in the core is above its saturation level. The general solutions are acquired in a dimensionless form by the Laplace transform and the solution for the special case-a perfect sink condition, is de...

journal_title：International journal of pharmaceutics

authors： Tongwen X,Binglin H

更新日期：2000-03-20 00:00:00

abstract：:Oral administration of proteins and peptides still is a challenging task to overcome due to low permeability through absorptive epithelia, degradation and metabolism that lead to poor bioavailability. Attempting to overcome such limitations, an antihypertensive peptide derived from whey protein, with KGYGGVSLPEW seque...

journal_title：International journal of pharmaceutics

authors： Castro PM,Baptista P,Madureira AR,Sarmento B,Pintado ME

更新日期：2018-08-25 00:00:00

abstract：:Hydrotalcite (HT), also known as a layered double hydroxide (LDH) compound, has been widely used in past years in the formulation of drugs due to its specific properties including good biocompatibility, null toxicity, high chemical stability and pH-dependent solubility which aid in drug controlled release. In this wor...

journal_title：International journal of pharmaceutics

authors： Djebbi MA,Bouaziz Z,Elabed A,Sadiki M,Elabed S,Namour P,Jaffrezic-Renault N,Amara AB

更新日期：2016-06-15 00:00:00

abstract：:Azithromycin loaded microspheres with blends of poly-l-lactide and ploy-D,L-lactide-co-glycolide as matrices were prepared by the atmosphere-solvent evaporation (ASE) and reduced pressure-solvent evaporation (RSE) method. Both the X-ray diffraction spectra and DSC thermographs demonstrated that poly-L-lactide existed ...

journal_title：International journal of pharmaceutics

authors： Li X,Chang S,Du G,Li Y,Gong J,Yang M,Wei Z

更新日期：2012-08-20 00:00:00

abstract：:Since the last decade, nanodispersed drug delivery systems gain increasingly more importance for therapeutic research fields. The forced transport to the centers of inflammation is supposed to take advantage as a novel strategic approach. Thus, the focus of this study was to investigate the applicability of ubiquinone...

journal_title：International journal of pharmaceutics

authors： Hoennscheidt C,Margaritis A,Krull R

更新日期：2015-01-15 00:00:00

abstract：:To avoid the clinical inconvenience of repeated injection of the immune modulator thymopentin (TP5), biodegradable implants comprising a mixed polymer matrix of poly(lactide acid) (PLA) and poly(lactide-co-glycolide acid) (PLGA) were produced using a simple extrusion method. Drug release from these TP5-loaded implants...

journal_title：International journal of pharmaceutics

authors： Wei G,Jin L,Xu L,Liu Y,Lu W

更新日期：2010-10-15 00:00:00

abstract：:A formyl group-ended poly(DL-lactic acid) (PLA-aldehyde), synthesized in the same manner as reported previously, was utilized to produce the polymeric marker for PLA-related nanoparticles. Namely, pyrene-ended poly(DL-lactic acid) (PLA-pyrene) was prepared as a polymeric marker by the reductive amination of PLA-aldehy...

journal_title：International journal of pharmaceutics

authors： Sasatsu M,Onishi H,Machida Y

更新日期：2008-06-24 00:00:00

abstract：:The high incidence of degenerative tears and prevalence of retears (20-95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of ...

journal_title：International journal of pharmaceutics

authors： Prabhath A,Vernekar VN,Sanchez E,Laurencin CT

更新日期：2018-06-15 00:00:00

abstract：:A gastroretentive drug delivery system of DA-6034, a new synthetic flavonoid derivative, for the treatment of gastritis was developed by using effervescent floating matrix system (EFMS). The therapeutic limitations of DA-6034 caused by its low solubility in acidic conditions were overcome by using the EFMS, which was ...

journal_title：International journal of pharmaceutics

authors： Jang SW,Lee JW,Park SH,Kim JH,Yoo M,Na DH,Lee KC

更新日期：2008-05-22 00:00:00

abstract：:The aim of the present work was the development of sponge-like dressings, obtained by freeze-drying, based on chitosan glutamate and sodium hyaluronate for platelet lysate (PL) delivery to chronic skin wounds. A first phase of the research focused on the choice of the best dressing composition to obtain formulations e...

journal_title：International journal of pharmaceutics

authors： Rossi S,Faccendini A,Bonferoni MC,Ferrari F,Sandri G,Del Fante C,Perotti C,Caramella CM

更新日期：2013-01-20 00:00:00

abstract：:Electro-gene-therapy is a promising technique for cancer treatment. However, knowledge about mechanism of gene transfer with electric field in tumor is limited. Whereas in vitro electrotransfection is efficient, gene expression in tumoral cells in vivo is weak. To determine reasons for this difference and unravel gene...

journal_title：International journal of pharmaceutics

authors： Chopinet L,Wasungu L,Rols MP

更新日期：2012-02-14 00:00:00

abstract：:We have evaluated a miniaturized in vitro method, based on the μDISS Profiler™ technique that enables on-line monitoring of drug release from a 21 μl sample with 10 ml of release medium. Four model drugs in eight clinically used formulations, including both solid and non-solid drug delivery systems, were investigated....

journal_title：International journal of pharmaceutics

authors： Ahnfelt E,Sjögren E,Axén N,Lennernäs H

更新日期：2015-01-01 00:00:00

abstract：:The main purpose of this study was to develop self-emulsifying drug delivery systems (SEDDS) for the improvement of the stability of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) after released from poly (D,L-lactide-co-glycolide) (PLGA) wafer and to evaluate its in vitro antitumor activity against 9L gliosarcoma cells....

journal_title：International journal of pharmaceutics

authors： Chae GS,Lee JS,Kim SH,Seo KS,Kim MS,Lee HB,Khang G

更新日期：2005-09-14 00:00:00

abstract：:Solid lipid nanoparticles (SLN) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinit...

journal_title：International journal of pharmaceutics

authors： Souto EB,Anselmi C,Centini M,Müller RH

更新日期：2005-05-13 00:00:00

abstract：:Calcium phosphate nanoparticles present a unique class of non-viral vectors, which can serve as efficient and alternative DNA carriers for targeted delivery of genes. In this study we report the design and synthesis of ultra-low size, highly monodispersed DNA doped calcium phosphate nanoparticles of size around 80 nm ...

journal_title：International journal of pharmaceutics

authors： Roy I,Mitra S,Maitra A,Mozumdar S

更新日期：2003-01-02 00:00:00

abstract：:It has been demonstrated that orally administered cholestyramine is distributed throughout the stomach and provides prolonged gastric residence via mucoadhesion. Gamma scintigraphy was used to compare the gastric emptying and residence of this resin with two formulations known to exhibit retentive or bioadhesive prope...

journal_title：International journal of pharmaceutics

authors： Jackson SJ,Bush D,Perkins AC

更新日期：2001-01-05 00:00:00

abstract：:In this study, solid lipid nanoparticles (SLN) loaded with MBO-asGCS oligonucleotide were prepared, characterized and evaluated for cytotoxicity against NCI/ADR-RES human ovary cancer cells. Two types of cetyltrimethyl ammonium bromide (CTAB) stabilized SLN, with or without ceramide VI, were prepared by mixed homogeni...

journal_title：International journal of pharmaceutics

authors： Siddiqui A,Patwardhan GA,Liu YY,Nazzal S

更新日期：2010-11-15 00:00:00

abstract：:Amorphous nanoparticles are able to enhance the kinetic solubility and concomitant dissolution rates of BCS class II and BCS class II/IV molecules due to their characteristic increased supersaturation levels, smaller particle size and greater surface area. A DoE approach was applied to investigate formulation and spra...

journal_title：International journal of pharmaceutics

authors： Jog R,Kumar S,Shen J,Jugade N,Tan DC,Gokhale R,Burgess DJ

更新日期：2016-02-10 00:00:00