当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications.

Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications.

Abstract：

:Medicine formulations at the nanoscale, referred to as nanomedicines, have managed to overcome key challenges encountered during the development of new medical treatments and entered clinical practice, but considerable improvement in terms of local efficacy and reduced toxicity still need to be achieved. Currently, the fourth-generation of nanomedicines is being developed, employing biocompatible nanocarriers that are targeted, multifunctional, and stimuli-responsive. Proteins and polypeptides can fit the standards of an efficient nanovector because of their biodegradability, intrinsic bioactivity, chemical reactivity, stimuli-responsiveness, and ability to participate in complex supramolecular assemblies. These biomacromolecules can be obtained from natural resources, produced in heterologous hosts, or chemically synthesized, allowing for different designs to access suitable carriers for a variety of drugs. To enhance targeting or therapeutic functionality, additional chemical modifications can be applied. This review demonstrates the potential of polypeptide and protein materials for the design of drug delivery nanocarriers with a special focus on their preclinical evaluation in vitro and in vivo.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Georgilis E,Abdelghani M,Pille J,Aydinlioglu E,van Hest JCM,Lecommandoux S,Garanger E

doi

10.1016/j.ijpharm.2020.119537

subject

Has Abstract

pub_date

2020-08-30 00:00:00

pages

119537

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(20)30521-4

journal_volume

586

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery.

    abstract：:pH-responsive polymer shell chitosan/poly (methacrylic acid) (CS-PMAA) was coated on mesoporous silica nanoparticles (MSN) through the facile in situ polymerization method. The resultant composite microspheres showed a flexible control over shell thickness, surface charges and hydrodynamic size by adjusting the feedin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.10.013

    authors： Tang H,Guo J,Sun Y,Chang B,Ren Q,Yang W

    更新日期：2011-12-15 00:00:00

  • Development and characterization of layer-by-layer coated liposomes with poly(L-lysine) and poly(L-glutamic acid) to increase their resistance in biological media.

    abstract：:Multilayered coated liposomes were prepared using the layer-by-layer (LbL) technique in an effort to improve their stability in biological media. The formulation strategy was based on the alternate deposition of two biocompatible and biodegradable polyelectrolytes - poly(L-lysine) (PLL) and poly(L-glutamic acid) (PGA)...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119568

    authors： Hermal F,Frisch B,Specht A,Bourel-Bonnet L,Heurtault B

    更新日期：2020-08-30 00:00:00

  • Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis.

    abstract：:Poloxamer-407 (P-407) is a nonionic surfactant that induces atheroma formation in the aortas of C57BL/6 mice with long-term (14 weeks) administration. The objectives of the present study were to determine the mechanism(s) responsible for the induction of hypercholesterolemia as well as to determine whether this animal...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00834-1

    authors： Johnston TP,Nguyen LB,Chu WA,Shefer S

    更新日期：2001-10-23 00:00:00

  • Complexation of cationic-neutral block polyelectrolyte with insulin and in vitro release studies.

    abstract：:Insulin (INS) was incorporated into complexes with the block polyelectrolyte quaternized poly[3,5-bis(dimethylaminomethylene)hydroxystyrene]-b-poly(ethylene oxide) (QNPHOSEO), which is a cationic-neutral block polyelectrolyte. Light scattering techniques are used in order to examine the size, the size distribution and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.06.013

    authors： Pippa N,Karayianni M,Pispas S,Demetzos C

    更新日期：2015-08-01 00:00:00

  • Paediatric formulations--getting to the heart of the problem.

    abstract：:Many medicines prescribed for children are unlicensed. Solid dosage forms present problems as children have difficulty swallowing whole tablets or capsules. When medicines are not licensed for children, it is unlikely that there will be a suitable, licensed liquid formulation and so extemporaneous liquid preparations ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.05.006

    authors： Standing JF,Tuleu C

    更新日期：2005-08-26 00:00:00

  • Radioprotective effect of self-assembled low molecular weight Fucoidan-Chitosan nanoparticles.

    abstract：:Fucoidan, a sulphated polysaccharide, plays a vital role in reducing cellular oxidative damage by exerting potential antioxidant activity. However, because of the negative surface charges of oligofucoidan, it shows poor oral intestinal absorption. To overcome this drawback, the oligofucoidan polysaccharides self-assem...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119161

    authors： Wu SY,Parasuraman V,Hsieh-Chih-Tsai,Arunagiri V,Gunaseelan S,Chou HY,Anbazhagan R,Lai JY,Prasad N R

    更新日期：2020-04-15 00:00:00

  • Combinatorial MAPLE deposition of antimicrobial orthopedic maps fabricated from chitosan and biomimetic apatite powders.

    abstract：:Chitosan/biomimetic apatite thin films were grown in mild conditions of temperature and pressure by Combinatorial Matrix-Assisted Pulsed Laser Evaporation on Ti, Si or glass substrates. Compositional gradients were obtained by simultaneous laser vaporization of the two distinct material targets. A KrF* excimer (λ=248n...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.015

    authors： Visan A,Stan GE,Ristoscu C,Popescu-Pelin G,Sopronyi M,Besleaga C,Luculescu C,Chifiriuc MC,Hussien MD,Marsan O,Kergourlay E,Grossin D,Brouillet F,Mihailescu IN

    更新日期：2016-09-10 00:00:00

  • Development of new polymer-based particulate systems for anti-glioma vaccination.

    abstract：:Biodegradable and biocompatible microspheres represent a promising alternative to conventional adjuvants for anti-tumour vaccination. Focusing on glioma, we developed two poly(D,L-lactide-co-glycolide) (PLGA)-based particulate systems presenting tumour antigens associated with plasma membranes or with cell lysates. Gl...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.10.046

    authors： Sapin A,Garcion E,Clavreul A,Lagarce F,Benoit JP,Menei P

    更新日期：2006-02-17 00:00:00

  • New amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp.

    abstract：:Amphotericin B (AmB) has a broad antifungal and leishmanicidal activity with low incidence of clinical resistance. Its parenteral administration has high risk of nephrotoxicity that limits its use. In order to treat cutaneous infections, AmB topical administration is a safer therapy because of the low systemic absorpt...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.07.004

    authors： Ruiz HK,Serrano DR,Dea-Ayuela MA,Bilbao-Ramos PE,Bolás-Fernández F,Torrado JJ,Molero G

    更新日期：2014-10-01 00:00:00

  • Investigating the moisture-induced crystallization kinetics of spray-dried lactose.

    abstract：:Gravimetric water sorption experiments were performed to study the crystallization behavior of amorphous spray-dried lactose over a wide range of temperature and humidity conditions. Experiments performed at 25 degrees C between 48 and 60% relative humidity (RH) showed that the onset time to crystallization increased ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.01.012

    authors： Burnett DJ,Thielmann F,Sokoloski T,Brum J

    更新日期：2006-04-26 00:00:00

  • An apolipoprotein E modified liposomal nanoparticle: ligand dependent efficiency as a siRNA delivery carrier for mouse-derived brain endothelial cells.

    abstract：:A disorder in the brain endothelium is thought to be closely related to the pathophysiology of brain diseases. A method for delivering nucleic acids (i.e. short interference RNA; siRNA) to the brain endothelium should be an attractive strategy for curing brain disorders. A liposomal nanoparticle containing a proton-io...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.02.016

    authors： Tamaru M,Akita H,Kajimoto K,Sato Y,Hatakeyama H,Harashima H

    更新日期：2014-04-25 00:00:00

  • Effect of aqueous solubility of grafted moiety on the physicochemical properties of poly(d,l-lactide) (PLA) based nanoparticles.

    abstract：:In order to evaluate the solubility effect of grafted moiety on the physicochemical properties of poly(d,l-lactide) (PLA) based nanoparticles (NPs), two materials of completely different aqueous solubility, polyethylene glycol (PEG) and palmitic acid were grafted on PLA backbone at nearly the same grafting density, 2....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.12.059

    authors： Essa S,Rabanel JM,Hildgen P

    更新日期：2010-03-30 00:00:00

  • A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence.

    abstract：:Liver dysfunction is associated with a variety of liver diseases, including viral or alcoholic hepatitis, fibrosis, cirrhosis, and portal hypertension. A targeted drug delivery system would be very useful in the treatment of these diseases. We herein describe the development of a system comprised of a new peptide-lipi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.068

    authors： Akhter A,Hayashi Y,Sakurai Y,Ohga N,Hida K,Harashima H

    更新日期：2013-11-01 00:00:00

  • Ligand anchored dendrimers based nanoconstructs for effective targeting to cancer cells.

    abstract：:Dendrimers are considered versatile carriers especially for the treatment of diseases like cancer, AIDS, malaria etc. Cancer is a worldwide threat particularly in developing countries. A breakthrough research in this regard is a prime requirement. In the present study, folic acid was conjugated to fifth generation pol...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.04.002

    authors： Gupta U,Dwivedi SK,Bid HK,Konwar R,Jain NK

    更新日期：2010-06-30 00:00:00

  • Synthesis and characterization of biocompatible poly(organophosphazenes) aiming for local delivery of protein drugs.

    abstract：:Biocompatible and thermosensitive poly(organophosphazenes) with a lower critical solution temperature (LCST) below body temperature have been designed with the aim for the local delivery of peptide and protein drugs. These polymers could be synthesized by introducing short chain tri- or tetraethylene glycol as a hydro...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.02.009

    authors： Seong JY,Jun YJ,Kim BM,Park YM,Sohn YS

    更新日期：2006-05-11 00:00:00

  • Formulating powder-device combinations for salmeterol xinafoate dry powder inhalers.

    abstract：:Using salmeterol xinafoate (SX) as an active pharmaceutical ingredient, the effects of carrier lactose particle type, total lactose fines content and device resistance on dry powder inhaler performance were investigated in vitro. To mimic drug levels in commercial preparations, interactive mixtures containing 0.58% w/...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.028

    authors： Hassoun M,Ho S,Muddle J,Buttini F,Parry M,Hammond M,Forbes B

    更新日期：2015-07-25 00:00:00

  • Effects of carriers and storage of formulation on the lung deposition of a hydrophobic and hydrophilic drug from a DPI.

    abstract：:The effects of carriers, the drug:carrier ratio and a 1 month storage period of a formulation in permeable polystyrene tube at 40 degrees C/75% RH on the in vitro pulmonary deposition of model drugs from dry powder inhaler (DPI) were evaluated. Budesonide (hydrophobic) and salbutamol sulphate (hydrophilic) were used a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00357-0

    authors： Harjunen P,Lankinen T,Salonen H,Lehto VP,Järvinen K

    更新日期：2003-09-16 00:00:00

  • Formulation and evaluation of diclofenac sodium buccoadhesive discs.

    abstract：:Twenty diclofenac sodium buccoadhesive discs containing Cp974p, polycarbophil, PEO, SCMC-medium viscosity (SCMC-MV), SCMC-ultrahigh viscosity (SCMC-UHV) or their combinations were prepared. These buccoadhesive discs were evaluated for release pattern, swelling capacity, surface pH, mucoadhesion performance, and in vit...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.07.033

    authors： El-Samaligy MS,Yahia SA,Basalious EB

    更新日期：2004-11-22 00:00:00

  • Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride.

    abstract：:The feasibility of a colorimetric technique was investigated in CIELAB color space as an analytical quality control method for content uniformity of printed orodispersible pediatric delivery systems. Inkjet printing was utilized to fabricate orodispersibe film formulations containing propranolol hydrochloride in a col...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.032

    authors： Vakili H,Nyman JO,Genina N,Preis M,Sandler N

    更新日期：2016-09-10 00:00:00

  • Development of enteric polymer-based microspheres by spray-drying for colonic delivery of Lactobacillus rhamnosus GG.

    abstract：:Antibiotics are well-known disruptive elements of the intestinal microbiota and antibiotic-associated diarrhea appeared as the most common complication related with post-antibiotic dysbiosis. Lactobacillus rhamnosus GG (LGG) strain is very effective in preventing antibiotic-associated diarrhea in children and adults. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119414

    authors： Akanny E,Bourgeois S,Bonhommé A,Commun C,Doleans-Jordheim A,Bessueille F,Bordes C

    更新日期：2020-06-30 00:00:00

  • Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing.

    abstract：:An ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the benefits of incorporating it in a continuous line, manufacturing solid dosage forms. Tablets containing lactose, acetaminophen, and magnesium stearate ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.04.064

    authors： Razavi SM,Callegari G,Drazer G,Cuitiño AM

    更新日期：2016-06-30 00:00:00

  • Validation of a continuous granulation process using a twin-screw extruder.

    abstract：:Using twin-screw granulation as particle size enlargement technique, the effect of modifying the screw configuration (number of mixing zones, configuration of kneading block) on granule quality, tablet properties and mixing efficiency was investigated. The amount of oversized agglomerates and yield was significantly i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.012

    authors： Van Melkebeke B,Vervaet C,Remon JP

    更新日期：2008-05-22 00:00:00

  • Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin.

    abstract：:As with many other anti-cancer agents, docetaxel is a substrate for ATP-binding cassette transporters such as P-glycoprotein and its metabolism is mainly catalysed by CYP3A. In order to improve the oral bioavailability of docetaxel, a component of turmeric, curcumin, which can down-regulate the intestinal P-glycoprote...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.08.015

    authors： Yan YD,Kim DH,Sung JH,Yong CS,Choi HG

    更新日期：2010-10-31 00:00:00

  • Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: An in vivo study.

    abstract：:Topical preparations of capsaicin, the major pungent ingredient of hot pepper, are being used for management of pain and inflammatory disorders. Purpose of this study was to use nanoemulsion as an effective topical drug carrier for in vivo delivery of capsaicin. An oil-in-water nanoemulsion containing capsaicin was pr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.043

    authors： Ghiasi Z,Esmaeli F,Aghajani M,Ghazi-Khansari M,Faramarzi MA,Amani A

    更新日期：2019-03-25 00:00:00

  • Influence of dissolution medium buffer composition on ketoprofen release from ER products and in vitro-in vivo correlation.

    abstract：:The purpose of this work was to investigate the influence of dissolution medium composition on the in vitro release of ketoprofen from a series of ER products and the impact of the different buffer media on the in vivo-in vitro (IVIV) relationship. The products investigated were coated micro bead preparations having i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00004-8

    authors： Corrigan OI,Devlin Y,Butler J

    更新日期：2003-03-26 00:00:00

  • A novel image analysis methodology for online monitoring of nucleation and crystal growth during solid state phase transformations.

    abstract：:This study focuses on the development of an automated image analysis method to extract information on nucleation and crystal growth from polarized light micrographs. Using the developed image analysis method, four parameters related to nucleation and crystal growth could be extracted from the images. These parameters ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.04.074

    authors： Wu JX,Xia D,van den Berg F,Amigo JM,Rades T,Yang M,Rantanen J

    更新日期：2012-08-20 00:00:00

  • Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors.

    abstract：:Poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) and newly developed poly(ethylene oxide)-block-poly(alpha-benzyl carboxylate epsilon-caprolactone) (PEO-b-PBCL) micelles were evaluated for the solubilization and delivery of cucurbitacin I and B, poorly water soluble inhibitors of signal transducer and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.06.032

    authors： Molavi O,Ma Z,Mahmud A,Alshamsan A,Samuel J,Lai R,Kwon GS,Lavasanifar A

    更新日期：2008-01-22 00:00:00

  • Enhanced properties of discrete pulmonary deoxyribonuclease I (DNaseI) loaded PLGA nanoparticles during encapsulation and activity determination.

    abstract：:In the present work, DNaseI loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) for pulmonary delivery were prepared using emulsion solvent evaporation. The effects of the various formulation and experimental variables on the size and morphological characteristics of the particles as well as on the encapsu...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.02.013

    authors： Osman R,Kan PL,Awad G,Mortada N,El-Shamy AE,Alpar O

    更新日期：2011-04-15 00:00:00

  • PAMAM dendrimers and model membranes: differential scanning calorimetry studies.

    abstract：:Dendrimers attract much attention as potential drug and gene carriers for intracellular delivery. From this point of view, it is crucial to extend our knowledge about their interactions with membranes. The influence of polyamidoamine (PAMAM) dendrimers on the thermotropic behavior of DPPC multilamellar vesicles and DM...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.08.015

    authors： Klajnert B,Epand RM

    更新日期：2005-11-23 00:00:00

  • Permeation studies through porcine small intestine of furosemide solutions for personalised paediatric administration.

    abstract：:Personalized medicine is a challenging research area in paediatric drug design since no suitable pharmaceutical forms are currently available. Furosemide is an anthranilic acid derivative used in paediatric practice to treat cardiac and pulmonary disorders in premature infants and neonates. However, it is not commerci...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.08.059

    authors： Provenza N,Calpena AC,Mallandrich M,Sánchez A,Egea MA,Clares B

    更新日期：2014-11-20 00:00:00