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Formulating powder-device combinations for salmeterol xinafoate dry powder inhalers.

Abstract：

:Using salmeterol xinafoate (SX) as an active pharmaceutical ingredient, the effects of carrier lactose particle type, total lactose fines content and device resistance on dry powder inhaler performance were investigated in vitro. To mimic drug levels in commercial preparations, interactive mixtures containing 0.58% w/w SX were prepared by low shear tumble mixing. Three types of milled inhalation grade lactose were used (Lactohale(®) LH 200, Respitose(®) ML006 and ML001) and the concentration of fine lactose (Lactohale(®) 300) added was varied. The in vitro deposition of each mixture was studied using a next generation impactor and inhaler devices exhibiting different resistances, Rotahaler(®)80% ED and MMAD ± GSD between 1-5 μm. The results confirmed the factors under investigation to be important determinants of product performance, but demonstrated using realistic conditions how individual factor impact may be enhanced or mitigated by inter-dependency.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Hassoun M,Ho S,Muddle J,Buttini F,Parry M,Hammond M,Forbes B

doi

10.1016/j.ijpharm.2015.05.028

subject

Has Abstract

pub_date

2015-07-25 00:00:00

pages

360-7

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)00447-0

journal_volume

490

pub_type

杂志文章

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