Abstract：
:This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Laffleur F,Krouská J,Tkacz J,Pekař M,Aghai F,Netsomboon Kdoi
10.1016/j.ijpharm.2018.08.032subject
Has Abstractpub_date
2018-10-25 00:00:00pages
309-315issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(18)30603-3journal_volume
550pub_type
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