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Study of branched cationic beta-cyclodextrin polymer/indomethacin complex and its release profile from alginate hydrogel.

Abstract：

:A series of branched cationic beta-cyclodextrin polymers (CPbetaCDs) with designed chemical structures were synthesized from beta-cyclodextrin (beta-CD), epichlorohydrin (EP) and choline chloride (CC). Indomethacin (IDM), an anionic drug, was chosen as a model drug to evaluate the drug loading capacities of CPbetaCDs. The formation of IDM-CPbetaCD complex was confirmed by (1)H NMR and DSC. Phase solubility studies and Job plots indicated that CPbetaCDs can solubilize IDM up to 100 times of its intrinsic solubility in a 1:1 complexation form. Mechanism studies with the help of adamantane revealed that the effective complexation is a combination of inclusion complexation, charge interaction and hydrophobic interaction. In addition, IDM-CPbetaCDs loaded alginate hydrogels were prepared and obtained controllable release profile in dissolution tests. The tunable structures of CPbetaCDs make them promising drug carriers with superior drug loading capacities and controllable drug release abilities.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Xin J,Guo Z,Chen X,Jiang W,Li J,Li M

doi

10.1016/j.ijpharm.2009.11.024

subject

Has Abstract

pub_date

2010-02-15 00:00:00

pages

221-8

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(09)00845-X

journal_volume

386

pub_type

杂志文章

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