当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Thermosensitivity and release from poly N-isopropylacrylamide-polylactide copolymers.

Thermosensitivity and release from poly N-isopropylacrylamide-polylactide copolymers.

Abstract：

:A series of thermoresponsive-co-biodegradable polymers, containing varying molar ratios of N-isopropylacrylamide (NIPA) and poly-lactic acid diacrylate macromer (PLAM) were prepared and characterised. Chemical structures were confirmed by nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR). The hydrogels were thermoresponsive, exhibiting an increase in the lower critical solution temperature (LCST) the higher the percent of PLAM present. Swelling properties were dependant on both temperature and PLAM content. The degradation behaviour of the three-dimensional polymeric networks formed was dependent on both structural (mesh size, molecular weight distribution, composition) and environmental parameters (temperature). Swelling and in vitro biodegradation-induced morphological structural changes were examined using scanning electron microscopy (SEM). A greater rate of degradation and disruption to the porous network could be seen with increasing lactide content. Degradation was faster below the LCST, demonstrated by FTIR, pH decrease and acid release, consistent with the increased hydrophilicity of the network. The release profiles of the model drug indomethacin (IDM), from these thermoresponsive-co-biodegradable polymers, were found to be dependant on copolymer composition, drug loading and temperature, more rapid release occurring below the LCST.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Chearúil FN,Corrigan OI

doi

10.1016/j.ijpharm.2008.08.036

subject

Has Abstract

pub_date

2009-01-21 00:00:00

pages

21-30

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(08)00599-1

journal_volume

366

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Understanding Flow Properties of Mannitol Powder at a Range of Temperature and Humidity.

    abstract：:Inadequate flowability of powders in industries during handling can cause many problems. For example, lack of flow from hoppers, poor tablet weight consistency, and low production rate in tableting. Many factors are known to commonly affect flow properties of powders, such as temperature, humidity and conditioning dur...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2021.120244

    authors： Salehi H,Karde V,Hajmohammadi H,Dissanayake S,Larsson SH,Y Y Heng J,Bradley M

    更新日期：2021-01-20 00:00:00

  • Controlling granule size by granulation liquid feed pulsing.

    abstract：:The effects of inlet air humidity, granulation liquid feed rate and granulation liquid feed pulsing on the particle-size distribution of final granules were studied in a laboratory scale fluid-bed granulator using a central composite study design. The factors examined were modelled using three different particle-size ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.060

    authors： Närvänen T,Lipsanen T,Antikainen O,Räikkönen H,Yliruusi J

    更新日期：2008-06-05 00:00:00

  • Effects of polyamidoamine (PAMAM) dendrimers on the nasal absorption of poorly absorbable drugs in rats.

    abstract：:The absorption enhancing effects of polyamidoamine (PAMAM) dendrimers with various concentrations and generations on the nasal absorption of fluorescein isothiocyanate-labeled dextran with an average molecular weight of 4400 (FD4) were initially studied in rats. PAMAM dendrimers with different generations improved the...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.04.021

    authors： Dong Z,Katsumi H,Sakane T,Yamamoto A

    更新日期：2010-06-30 00:00:00

  • Formulation and in-vitro evaluation of directly compressed controlled release matrices of Losartan Potassium using Ethocel Grade 100 as rate retarding agent.

    abstract：:Current study was aimed to develop 200mg controlled release matrix tablets of Losartan Potassium using Ethocel 100 Premium and Ethocel 100 FP Premium as rate controlling polymer. In-vitro studies were performed according to USP Method-I in phosphate buffer (PH 6.8) using pharma test dissolution apparatus. The temperat...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.051

    authors： Khan KA,Khan GM,Zeeshan Danish M,Akhlaq,Khan H,Rehman F,Mehsud S

    更新日期：2015-12-30 00:00:00

  • Multi-functional self-assembled nanoparticles for pVEGF-shRNA loading and anti-tumor targeted therapy.

    abstract：:Although RNA interference (RNAi) technology shows great potential in cancer treatment, the tumor target delivery and sufficient cytosolic transport of RNAi agents are still the main obstacles for its clinical applications. Herein, we report a functional supramolecular self-assembled nanoparticle vector for RNAi agent ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118898

    authors： Lu S,Bao X,Hai W,Shi S,Chen Y,Yu Q,Zhang M,Xu Y,Peng J

    更新日期：2020-02-15 00:00:00

  • Microemulsions containing long-chain oil ethyl oleate improve the oral bioavailability of piroxicam by increasing drug solubility and lymphatic transportation simultaneously.

    abstract：:Drug solubility and lymphatic transport enhancements are two main pathways to improve drug oral bioavailability for microemulsions. However, it is not easy to have both achieved simultaneously because excipients used for improving lymphatic transport were usually insufficient in forming microemulsions and solubilizing...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.061

    authors： Xing Q,Song J,You X,Xu D,Wang K,Song J,Guo Q,Li P,Wu C,Hu H

    更新日期：2016-09-25 00:00:00

  • Electrospun protein nanofibers in healthcare: A review.

    abstract：:Electrospun nanofibers are being utilized for a wide range of healthcare applications. A plethora of natural and synthetic polymers are exploited for their ability to be electrospun and replace the complex habitat provided by the extracellular matrix for the cells. The fabrication of nanofibers can be tuned to act as ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.03.013

    authors： Babitha S,Rachita L,Karthikeyan K,Shoba E,Janani I,Poornima B,Purna Sai K

    更新日期：2017-05-15 00:00:00

  • Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids.

    abstract：:A drug carrier of colloidal lipid particles with improved payloads and enhanced storage stability was investigated. Based on the experiences with hard fats nanoparticles, a new type of solid lipid nanoparticles (SLN) has been developed by incorporating triglyceride containing oils in the solid core of said particle. T...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00378-1

    authors： Jenning V,Thünemann AF,Gohla SH

    更新日期：2000-04-20 00:00:00

  • Enhancement in bioavailability of ketorolac tromethamine via intranasal in situ hydrogel based on poloxamer 407 and carrageenan.

    abstract：:The objective of this study was to construct a new in situ gel system based on the combination of poloxamer 407 and carrageenan (carrageenan-poloxamer 407 hydrogel, CPH) for intranasal delivery of ketorolac tromethamine. CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow eros...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.08.023

    authors： Li C,Li C,Liu Z,Li Q,Yan X,Liu Y,Lu W

    更新日期：2014-10-20 00:00:00

  • The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems.

    abstract：:Neurological disorders have been growing in recent years and are highly prevalent globally. Resveratrol (RES) is a natural product from plant sources such as grape skins. This compound has shown biological activity in many diseases, in particular, those that act on the central nervous system. The mechanism of action a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2020.119832

    authors： Fonseca-Santos B,Chorilli M

    更新日期：2020-08-30 00:00:00

  • Effects of conditions for preparing nanoparticles composed of aminoethylcarbamoyl-beta-cyclodextrin and ethylene glycol diglycidyl ether on trap efficiency of a guest molecule.

    abstract：:Nanoparticles comprising copolymers of aminoethylcarbamoyl-beta-cyclodextrin (AEC-beta-CD) and ethylene glycol diglycidyl ether (EGDGE) are prepared by an interfacial polyaddition reaction in a miniemulsion system. Polymers are formed in a W/O emulsion containing 0.25-10.0% (w/w) water and 5.0% (w/w) surfactant (MO-3S...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.12.015

    authors： Eguchi M,Du YZ,Ogawa Y,Okada T,Yumoto N,Kodaka M

    更新日期：2006-03-27 00:00:00

  • Overview of solidification techniques for self-emulsifying drug delivery systems from industrial perspective.

    abstract：:Self-emulsifying drug delivery systems (SEDDS) are lipid formulations that improve solubility and oral bioavailability of the incorporated drug with poor biopharmaceutical properties. As liquids they are traditionally filled into soft or hard capsules. Transformation of SEDDS into solid dosage form has been extensivel...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.05.036

    authors： Mandić J,Zvonar Pobirk A,Vrečer F,Gašperlin M

    更新日期：2017-11-30 00:00:00

  • In vivo preclinical evaluation of the new 68Ga-labeled beta-cyclodextrin in prostaglandin E2 (PGE2) positive tumor model using positron emission tomography.

    abstract：:The cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays an important role in tumor development and formation of metastases. It was earlier reported that cyclodextrin derivatives have a high affinity to form complexes with PGE2. Based on these results radiolabeled cyclodextrins - as new radiopharmaceuticals ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118954

    authors： Trencsényi G,Kis A,Szabó JP,Ráti Á,Csige K,Fenyvesi É,Szente L,Malanga M,Méhes G,Emri M,Kertész I,Vecsernyés M,Fenyvesi F,Hajdu I

    更新日期：2020-02-25 00:00:00

  • A novel formulation of solubilised amphotericin B designed for ophthalmic use.

    abstract：:Amphotericin B (AmB) is a wide spectrum antifungal with low incidence of clinical resistance. However, there are no licensed topical formulations with AmB in most developed countries. Extemporaneous preparations of AmB are frequently prepared from available marketed parenteral formulations. Herein, a solution of AmB w...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.065

    authors： Serrano DR,Ruiz-Saldaña HK,Molero G,Ballesteros MP,Torrado JJ

    更新日期：2012-11-01 00:00:00

  • Prediction of drug-packaging interactions via molecular dynamics (MD) simulations.

    abstract：:The interaction between packaging materials and drug products is an important issue for the pharmaceutical industry, since during manufacturing, processing and storage a drug product is continuously exposed to various packaging materials. The experimental investigation of a great variety of different packaging materia...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.049

    authors： Feenstra P,Brunsteiner M,Khinast J

    更新日期：2012-07-15 00:00:00

  • Triclosan loaded electrospun nanofibers based on a cyclodextrin polymer and chitosan polyelectrolyte complex.

    abstract：:This work focuses on the relevance of antibacterial nanofibers based on a polyelectrolyte complex formed between positively charged chitosan (CHT) and an anionic hydroxypropyl betacyclodextrin (CD)-citric acid polymer (PCD) complexing triclosan (TCL). The study of PCD/TCL inclusion complex and its release in dynamic c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.09.060

    authors： Ouerghemmi S,Degoutin S,Tabary N,Cazaux F,Maton M,Gaucher V,Janus L,Neut C,Chai F,Blanchemain N,Martel B

    更新日期：2016-11-20 00:00:00

  • Selegiline-functionalized, PEGylated poly(alkyl cyanoacrylate) nanoparticles: Investigation of interaction with amyloid-β peptide and surface reorganization.

    abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder for which the research of new treatments is highly challenging. Since the fibrillogenesis of amyloid-β peptide 1-42 (Aβ(1-42)) peptide is considered as a major cause of neuronal degeneration, specific interest has been focused on aromatic molecules for targeting...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.01.015

    authors： Le Droumaguet B,Souguir H,Brambilla D,Verpillot R,Nicolas J,Taverna M,Couvreur P,Andrieux K

    更新日期：2011-09-20 00:00:00

  • Oral delivery of oleuropein-loaded lipid nanocarriers alleviates inflammation and oxidative stress in acute colitis.

    abstract：:Inflammation and oxidative stress pathways have emerged as novel targets in the management of inflammatory bowel diseases (IBD). Targeting the drug to the inflamed colon remains a challenge. Nanostructured lipid carriers (NLCs) have been reported to accumulate in inflamed colonic mucosa. The antioxidant/antiinflamator...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119515

    authors： Huguet-Casquero A,Xu Y,Gainza E,Pedraz JL,Beloqui A

    更新日期：2020-08-30 00:00:00

  • Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery.

    abstract：:The purpose of this study was to construct isotretinoin-loaded SLN (IT-SLN) formulation with skin targeting for topical delivery of isotretinoin. PRECIROL ATO 5 was selected as the lipid of SLN. Tween 80 and soybean lecithin were used as the surfactants to stabilize SLN. The hot homogenization method was performed to ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.08.007

    authors： Liu J,Hu W,Chen H,Ni Q,Xu H,Yang X

    更新日期：2007-01-10 00:00:00

  • PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma.

    abstract：:HN-1, a 12-amino acid peptide, has been reported to possess strong capabilities for targeting and penetrating head and neck squamous cell carcinoma. Here, we designed a simple but effective nanoparticle system for the delivery of doxorubicin (DOX) targeting oral squamous cell carcinoma (OSCC) through the mediation of ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.04.027

    authors： Wang Y,Wan G,Li Z,Shi S,Chen B,Li C,Zhang L,Wang Y

    更新日期：2017-06-15 00:00:00

  • Biomedical potentialities of cationic geminis as modulating agents of liposome in drug delivery across biological barriers and cellular uptake.

    abstract：:Hydroxyethyl bearing gemini surfactants, alkanediyl-α,ω-bis(N-hexadecyl-N-2-hydroxyethyl-N-methylammonium bromide), 16-s-16(OH), were used to augment phosphatidylcholine based liposomes to achieve higher stability and enhanced cellular uptake and penetration. The developed liposomes were loaded with rhodamine B, doxor...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119640

    authors： Pavlov RV,Gaynanova GA,Kuznetsova DA,Vasileva LA,Zueva IV,Sapunova AS,Buzyurova DN,Babaev VM,Voloshina AD,Lukashenko SS,Rizvanov IK,Petrov KA,Zakharova LY,Sinyashin OG

    更新日期：2020-09-25 00:00:00

  • Evaluation of childhood exposure to di(2-ethylhexyl) phthalate from perfusion kits during long-term parenteral nutrition.

    abstract：:Leachability of the plasticizer di(2-ethylhexyl) phthalate (DEHP) from administration sets into intravenous parenteral emulsions containing fat was investigated. DEHP is added to polyvinyl chloride (PVC) to impart flexibility. However, DEHP is a lipid-soluble suspected carcinogen that is hepatotoxic and teratogenic in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00335-1

    authors： Kambia K,Dine T,Gressier B,Bah S,Germe AF,Luyckx M,Brunet C,Michaud L,Gottrand F

    更新日期：2003-08-27 00:00:00

  • Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action.

    abstract：:This paper examines a perspective to use newly engineered nanomaterials as effective and safe carriers for gene therapy of cancer. Three different groups of cationic dendrimers (PAMAM, phosphorus, and carbosilane) were complexed with anticancer siRNA and the biophysical properties of the dendriplexes created were anal...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.03.034

    authors： Dzmitruk V,Szulc A,Shcharbin D,Janaszewska A,Shcharbina N,Lazniewska J,Novopashina D,Buyanova M,Ionov M,Klajnert-Maculewicz B,Gómez-Ramirez R,Mignani S,Majoral JP,Muñoz-Fernández MA,Bryszewska M

    更新日期：2015-05-15 00:00:00

  • Iontophoretic delivery of lipophilic and hydrophilic drugs from lipid nanoparticles across human skin.

    abstract：:The combined effects of iontophoresis and lipid nanoparticles on drug delivery across human epidermal membrane (HEM) were investigated. The delivery of lipophilic and hydrophilic drugs, all trans-retinoic acid (ATRA), salicylate (SA), and acyclovir (ACV), across HEM from lipid nanoparticles, solid lipid nanoparticles ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.08.094

    authors： Charoenputtakun P,Li SK,Ngawhirunpat T

    更新日期：2015-11-10 00:00:00

  • Development of cyclosporine A-loaded dry-emulsion formulation using highly purified glycerol monooleate for safe inhalation therapy.

    abstract：:The main objective of this study was to improve the safety and oxidative stability of glycerol monooleate (GMO)-based dry-emulsion (DE) formulation containing cyclosporine A (CsA) for inhalation therapy. GMO or highly purified GMO (hpGMO) was used as surfactant for the DE formulations (GMO/DE or hpGMO/DE), the toxicol...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.03.026

    authors： Sato H,Ogawa K,Kojo Y,Kawabata Y,Mizumoto T,Yamada S,Onoue S

    更新日期：2013-05-01 00:00:00

  • The role of internal and external stimuli in the rational design of skin-specific drug delivery systems.

    abstract：:The concept of skin-specific drug delivery with a spatio-temporal control has just recently received concerns in dermatology. Inspired by the progress in smart materials and their perspective application in medicine science, development of stimuli responsive drug delivery systems with skin-specificity has become possi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2020.120081

    authors： Chen Y,Chen N,Feng X

    更新日期：2021-01-05 00:00:00

  • Preparation and characterisation of hexamidine salts.

    abstract：:Hexamidine diisethionate (HEX D) has been used in the personal care industry and in a number of over-the-counter (OTC) drug products as an antimicrobial agent since the 1950's. Recently, the compound has also been investigated for its beneficial effects on skin health. Surprisingly, there is only limited information d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.07.071

    authors： Parisi N,Matts PJ,Lever R,Hadgraft J,Lane ME

    更新日期：2015-09-30 00:00:00

  • Polymer-based biomaterials for chronic wound management: Promises and challenges.

    abstract：:Chronic non-healing wounds tender a great challenge to patients, physicians, and wound care professionals. In view of the increasing prevalence of chronic wounds due to ischemia, diabetic foot, venous, and pressure ulcers, their appropriate management requires significant attention. Along with the basic techniques of ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2021.120270

    authors： Maaz Arif M,Maqsood Khan S,Gull N,Tabish TA,Zia S,Ullah Khan R,Muhammad Awais S,Arif Butt M

    更新日期：2021-01-21 00:00:00

  • Formulations and toxicologic in vivo studies of aqueous cyclosporin A eye drops with cyclodextrin nanoparticles.

    abstract：:Cyclosporin A (CyA) is an immunosuppressive drug used topically to treat ocular inflammatory disorder such as dry eye disease (DES). It is a lipophilic cyclic peptide with molecular weight of 1202.6Da. The aim of this study was to develop surfactant free aqueous 0.2% (w/v) CyA eye drops where the drug is present in an...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.07.044

    authors： Jóhannsdóttir S,Kristinsson JK,Fülöp Z,Ásgrímsdóttir G,Stefánsson E,Loftsson T

    更新日期：2017-08-30 00:00:00

  • Thermal dose as a universal tool to evaluate nanoparticle-induced photothermal therapy.

    abstract：:Thermal isoeffect dose (TID) is a widely applied concept to evaluate the safety of medical devices that can expose patients to heat. However, it has rarely been used in photothermal therapy (PTT), where nanoparticles are used as light absorbers. Utilizing TID in an appropriate way would make it feasible to compare the...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119657

    authors： Happonen E,Tamarov K,Martikainen MV,Ketola K,Roponen M,Lehto VP,Xu W

    更新日期：2020-09-25 00:00:00