Abstract:
:A biodegradable porous starch foam (BPSF) was developed for the first time as a carrier in order to improve the dissolution and enhance the oral bioavailability of lovastatin - defined as a model poorly water soluble BCS type II drug. In this paper, BPSF was prepared by the solvent exchange method and characterized by scanning electron microscopy (SEM) and nitrogen adsorption/desorption analysis in order to perform the morphological and structural characterization of BPSF. Lovastatin was loaded by immersion/solvent evaporation into the BPSF which provided a stable hydrophilic matrix with a nano-porous structure. The solid state properties of the loaded BPSF samples were characterized by SEM, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). In vitro and in vivo drug release studies showed that when BPSF was used as a carrier it allowed immediate release of lovastatin and enhanced the dissolution rate in comparison with crystalline lovastatin and commercial capsules. These results provide important information about the mechanism of drug adsorption and release from BPSF as a carrier. Accordingly, BPSF has a promising future as a device for the oral delivery of poorly water soluble drugs.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Wu C,Wang Z,Zhi Z,Jiang T,Zhang J,Wang Sdoi
10.1016/j.ijpharm.2010.09.040subject
Has Abstractpub_date
2011-01-17 00:00:00pages
162-9issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(10)00760-Xjournal_volume
403pub_type
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