Abstract：
:Dissolution research started to develop about 100 years ago as a field of physical chemistry and since then important progress has been made. However, explicit interest in drug related dissolution has grown only since the realisation that dissolution is an important factor of drug bioavailability in the 1950s. This review attempts to account the most important developments in the field, from a historical point of view. It is structured in a chronological order, from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the more recent developments in the framework of the Biopharmaceutics Classification System (BCS). Research on relevant fields of pharmaceutical technology, like sustained release formulations, where drug dissolution plays an important role, is reviewed. The review concludes with the modern trends on drug dissolution research and their regulatory implications.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Dokoumetzidis A,Macheras Pdoi
10.1016/j.ijpharm.2006.07.011subject
Has Abstractpub_date
2006-09-14 00:00:00pages
1-11issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(06)00581-3journal_volume
321pub_type
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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abstract：:Different types of Carbopols are frequently applied excipients of various dosage forms. Depending on the supramolecular structure, their water sorption behaviour could significantly differ. The purpose of the present study was to track the supramolecular changes of two types of Carbopol polymers (Carbopol 71G and Ultr...
journal_title：International journal of pharmaceutics
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更新日期：2018-07-10 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2007-09-05 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2014-10-01 00:00:00
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更新日期：2018-11-15 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：1999-10-15 00:00:00
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更新日期：2021-01-25 00:00:00
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pub_type： 杂志文章
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更新日期：2018-07-30 00:00:00
