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Pharmacokinetics of di-isononyl phthalate in freely moving rats by UPLC-MS/MS.

Abstract：

:Di-isononyl phthalate (DINP) is a general-purpose plasticizer for polyvinyl chloride. However, this industrial chemical plasticizer used as a clouding agent has recently contaminated food and beverages that had been inspected by Taiwan Food and Drug Administration. This study develops a sensitive and specific method combining ultra-performance liquid chromatography with electrospray ionization tandem mass spectrometry (UPLC-MS/MS) to investigate the pharmacokinetics of DINP in freely moving rats. Multiple reaction monitoring (MRM) was used to monitor the transition of the protonated molecule m/z of 419 [M+H](+) to the product ion 149 for DINP. The analyte was analyzed by UPLC-MS/MS with C18 column (100×2.1mm, 1.7 μm) which was equilibrated and eluted with an isocratic mixture of acetonitrile-ammonium acetate water solution (90:10, v/v) at a flow rate of 0.3 mL/min. Linear calibration curves were obtained for DINP concentration ranges of 0.05-2.5 μg/mL in plasma and feces. The feces were homogenized mechanically using 50% acetonitrile as the medium. The pharmacokinetic curve demonstrates that the disposition of DINP in rat plasma was fitted well by the two-compartment model after DINP administration (10 mg/kg, i.v.). The elimination half-life of DINP was 364±146 min and 150±58 min for intravenous (10 mg/kg) and oral (100 mg/kg) administration, respectively. The pharmacokinetic data indicate that the oral bioavailability of DINP in freely moving rats was about 1.19%. The total DINP excretion up to 48 h was 13.64±3.99% in feces.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Hou ML,Chang LW,Chiang CJ,Tsuang YH,Lin CH,Tsai TH

doi

10.1016/j.ijpharm.2013.04.033

subject

Has Abstract

pub_date

2013-06-25 00:00:00

pages

36-43

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(13)00334-7

journal_volume

450

pub_type

杂志文章

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