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On iontophoretic delivery enhancement: ionization and transport properties of lidocaine hydrochloride in aqueous propylene glycol.

Abstract：

:The ionization and transport properties of lidocaine hydrochloride (LidHCl) in aqueous propylene glycol (PG) containing 20% PG by weight was studied by means of electrical precision conductometry. For drug concentrations exceeding about 1.7 mM a slight formation of LidH(+)Cl(-) ion-pairs is indicated; ion-pair association constant, K(p)=1.73 (molar scale). A two variable analysis of the experimental data yielded K(a)=1.5x10(-8) for the acid dissociation constant of LidH(+), i.e. pK(a)=7.82, and the limiting ionic conductivity, lambda(o)(LidH(+))=21.73 cm(2) S mol(-1). To enable evaluation of single ion conductivities the proton transport number of HCl in the present solvent mixture was determined using the moving boundary method.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Karami K,Merclin N,Brounéus F,Beronius P

doi

10.1016/s0378-5173(00)00400-2

keywords:

subject

Has Abstract

pub_date

2000-05-15 00:00:00

pages

121-4

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(00)00400-2

journal_volume

201

pub_type

杂志文章

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