Abstract：
:The improvements in healthcare systems and the advent of the precision medicine initiative have created the need to develop more innovative manufacturing methods for the delivery and production of individualized dosing and personalized treatments. In accordance with the changes observed in healthcare systems towards more innovative therapies, this paper presents dropwise additive manufacturing of pharmaceutical products (DAMPP) for small scale, distributed manufacturing of individualized dosing as an alternative to conventional manufacturing methods A dropwise additive manufacturing process for amorphous and self-emulsifying drug delivery systems is reported, which utilizes drop-on-demand printing technology for automated and controlled deposition of melt-based formulations onto inert tablets. The advantages of drop on demand technology include reproducible production of droplets with adjustable sizing and high placement accuracy, which enable production of individualized dosing even for low dose and high potency drugs. Flexible use of different formulations, such as lipid-based formulations, allows enhancement of the solubility of poorly water soluble and highly lipophilic drugs with DAMPP. Here, DAMPP is used to produce solid oral dosage forms from melts of an active pharmaceutical ingredient and a surfactant. The dosage forms are analyzed to show the amorphous nature, self-emulsifying drug delivery system characteristics and dissolution behavior of these formulations.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Içten E,Purohit HS,Wallace C,Giridhar A,Taylor LS,Nagy ZK,Reklaitis GVdoi
10.1016/j.ijpharm.2017.04.003subject
Has Abstractpub_date
2017-05-30 00:00:00pages
424-432issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30283-1journal_volume
524pub_type
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