One-week in vivo sustained release of a peptide formulated into in situ forming implants.

abstract：:The aim of this study was to investigate the feasibility of the transdermal delivery of catechins and caffeine from green tea extract. Drug-in-adhesive patches containing 1.35, 1.03, 0.68, and 0.32 mg cm(-2) green tea extract were formulated and the dissolution of (-)-epigallocatechin gallate (EGCg), (-)-epigallocatec...

journal_title：International journal of pharmaceutics

authors： Batchelder RJ,Calder RJ,Thomas CP,Heard CM

更新日期：2004-09-28 00:00:00

abstract：:Nalbuphine is a semi-synthetic opioid indicated for the relief of moderate to severe pain. Dinalbuphine sebacate (DNS) is a prodrug of nalbuphine for which we have developed long-acting lipophilic formulations in a benzyl benzoate/sesame oil mixture for intramuscular (IM) injection. In this study, we found that the in...

journal_title：International journal of pharmaceutics

authors： Li CJ,Ku MY,Lu CY,Tien YE,Chern WH,Huang JD

更新日期：2017-10-05 00:00:00

abstract：:Liposomes, coated with transferrin (Tf)-coupled polyethylene glycol are considered to be potent carriers for drug delivery to various organs via receptor-mediated endocytosis. Since Tf receptors were ubiquitously expressed in various organs, additional perturbation of the liposomes such as regulation of the size may b...

journal_title：International journal of pharmaceutics

authors： Hatakeyama H,Akita H,Maruyama K,Suhara T,Harashima H

更新日期：2004-08-20 00:00:00

abstract：:Drugs in the gastrointestinal tract are exposed to a medium of partially digested food, comprising mixtures of fat, protein and carbohydrate. The dissolution behaviour of itraconazole was evaluated in bio-relevant media which were developed to take this into account. Media containing milk with different fat contents, ...

journal_title：International journal of pharmaceutics

authors： Ghazal HS,Dyas AM,Ford JL,Hutcheon GA

更新日期：2009-01-21 00:00:00

abstract：:Lansoprazole (LPZ) is a representative drug that shows a high inter-subject variation of bioavailability (BA). Solid preparation composed of surfactant, adsorbent and LPZ were prepared to improve the dissolution and absorption of LPZ, and the BA of LPZ was measured in rats and dogs. As surfactant, Tween 80, polyoxy 60...

journal_title：International journal of pharmaceutics

authors： Ito Y,Arai H,Uchino K,Iwasaki K,Shibata N,Takada K

更新日期：2005-01-31 00:00:00

abstract：:The aim of the present work was to evaluate the effect of sustained release of potassium chloride semi-solid matrices prepared with different kinds and added amounts of Gelucires by the in vitro dissolution test and in vivo oral absorption study, and compared with a commercial product (slow-K). The results indicating ...

journal_title：International journal of pharmaceutics

authors： Wu PC,Tsai MJ,Huang YB,Chang JS,Tsai YH

更新日期：2002-08-28 00:00:00

abstract：:The focus of present investigation was to assess the utility of non-destructive techniques in the evaluation of risperidone solid dispersions (SD) with methyl-β-cyclodextrin (MBCD) and subsequent incorporation of the SD into orally disintegrating tablets (ODT) for a faster release of risperidone. The SD was prepared b...

journal_title：International journal of pharmaceutics

authors： Rahman Z,Zidan AS,Khan MA

更新日期：2010-11-15 00:00:00

abstract：:This work investigates the dispersion performance of fine lactose particles as function of processing time, and compares it to the API, using Beclomethasone Dipropionate (BDP) as model API. The total load of fine particles is kept constant in the formulations while the proportions of API and lactose fines are varied. ...

journal_title：International journal of pharmaceutics

authors： Thalberg K,Åslund S,Skogevall M,Andersson P

更新日期：2016-05-17 00:00:00

abstract：:Intracranial injection of the rodent adapted CAM/RB strain of measles virus (MV) induces encephalitis in CBA/ca mice. It has already been shown that cyclodextrins can be used as carriers to increase the antiviral activity of ribavirin (RBV) against MV in cellular model. In this study, the antiviral activity of a RBV/a...

journal_title：International journal of pharmaceutics

authors： Jeulin H,Grancher N,Kedzierewicz F,Finance C,Le Faou AE,Venard V

更新日期：2008-06-05 00:00:00

abstract：:The combination of a highly soluble salt form of a drug with a polymeric precipitation inhibitor has the potential to prolong drug supersaturation even following salt disproportionation. In this study, dissolution profiles of ibuprofen sodium in the presence of various cellulosic polymers, including hydroxypropyl meth...

journal_title：International journal of pharmaceutics

authors： Terebetski JL,Michniak-Kohn B

更新日期：2014-11-20 00:00:00

abstract：:The purpose of this research was to investigate drug dose, solubility, permeability, and their interplay, as key factors in oral formulation development for lipophilic drugs. A PEG400-based formulation was studied for five doses of the lipophilic drug carbamazepine, accounting for biorelevant dissolution of the dose i...

journal_title：International journal of pharmaceutics

authors： Fine-Shamir N,Beig A,Miller JM,Dahan A

更新日期：2020-05-30 00:00:00

abstract：:The study was aimed at evaluating whether the ocular hypotensive effect of melatonin (MEL) was enhanced by its encapsulation in cationic solid lipid nanoparticles (cSLN), as well as at determining the tolerability of these formulations on the ocular surface. MEL was loaded in cSLN that had already been shown to be sui...

journal_title：International journal of pharmaceutics

authors： Leonardi A,Bucolo C,Drago F,Salomone S,Pignatello R

更新日期：2015-01-15 00:00:00

abstract：:The effect of the protein stabilizers on the stability and aerosol performance of spray dried recombinant human growth hormone (SD rhGH) was investigated. rhGH solution was spray dried alone, with polysorbate 20 (at three concentrations of 0.05%, 0.01%, and 0.005%), Zn(2+) (by Zn(2+):rhGH molar ratio of 2:1 and 4:1), ...

journal_title：International journal of pharmaceutics

authors： Jalalipour M,Gilani K,Tajerzadeh H,Najafabadi AR,Barghi M

更新日期：2008-03-20 00:00:00

abstract：:Meso-tetraphenyl porphine (mTPP) is a highly lipophilic, fluorescent porphyrin derivate and it is used as photosensitizer on the treatment of malign neoplasms. The aim of this study was to prepare mTPP loaded pluronic F127 and polyethylene glycol-distearoyl phosphatidylethanolamine (PEG(2000)-DSPE) micelles to evaluat...

journal_title：International journal of pharmaceutics

authors： Sezgin Z,Yuksel N,Baykara T

更新日期：2007-03-06 00:00:00

abstract：:Methyl methacrylate (MMA) copolymers have recently been proposed as an alternative in controlled-release matrix tablets. The aims of this study were to assess the potential value of these copolymers as direct compression excipients and to investigate relationships between the physical and structural properties of the ...

journal_title：International journal of pharmaceutics

authors： Ferrero C,Jiménez-Castellanos MR

更新日期：2002-11-06 00:00:00

abstract：:Niacinamide-containing moisturisers are known be efficacious in alleviating dry skin conditions and improving stratum corneum (SC) barrier function. However, the mechanisms of action of niacinamide at the molecular level in the SC are still not well understood. Previously, we have reported the development of novel met...

journal_title：International journal of pharmaceutics

authors： Mohammed D,Crowther JM,Matts PJ,Hadgraft J,Lane ME

更新日期：2013-01-30 00:00:00

abstract：:Na-deoxycholate (Na-DOC) forms a viscous thixotropic gel when in contact with excess buffer systems. The resulting gels have been tested as novel drug carrier systems for topical use. The influence of differing amounts of mannitol, glycerol and xylitol on the viscous modulus (G"/Pa) was evaluated by oscillatory measur...

journal_title：International journal of pharmaceutics

authors： Valenta C,Nowack E,Bernkop-Schnürch A

更新日期：1999-08-05 00:00:00

abstract：:Controlled release of hydrophilic drugs from carriers is still faced with problems due to the poor compatibility of such substances with slowly degradable polymers leading to challenges regarding fabrication as well as undesired burst release of the encapsulated drugs. In this context, coaxial electrospinning being ca...

journal_title：International journal of pharmaceutics

authors： Wang J,Windbergs M

更新日期：2019-02-10 00:00:00

abstract：:Despite that in solution we cannot detect the interaction between Ni(2+) and mitoxantrone (MIT), Ni(2+) could mediate effective and stable MIT loading into large unilamellar vesicles (LUVs). The presence of nigericin had almost no influences on MIT encapsulation. However, in the presence of NH(3), the drug loading kin...

journal_title：International journal of pharmaceutics

authors： Cui J,Li C,Wang L,Wang C,Yang H,Li Y,Zhang L,Zhang L,Guo W,Liang M

更新日期：2009-02-23 00:00:00

abstract：:Lipid-Polycation-DNA complexes (LPD) is a promising non-viral system for nucleic acids delivery. Usually, LPD are prepared just before their use. In the present work, we have examined whether dehydration of a new type of LPD (named LPD100) might be a storage option. LPD100 comprises PEGylated histidylated polylysine/p...

journal_title：International journal of pharmaceutics

authors： Perche F,Lambert O,Berchel M,Jaffrès PA,Pichon C,Midoux P

更新日期：2012-02-14 00:00:00

abstract：:Preparation conditions of nanoparticles greatly influence their physicochemical characteristics. A factorial design was used to evaluate the influence of these conditions on the particle diameter, zeta potential, polydispersity, percentage recovery, and molecular weight of poly(isobutylcyanoacrylate) nanoparticles. Th...

journal_title：International journal of pharmaceutics

authors： McCarron PA,Woolfson AD,Keating SM

更新日期：1999-12-20 00:00:00

abstract：:The present investigation aims to develop lumefantrine loaded binary solid lipid nanoparticles (LF-SLNs) to improve its poor and variable oral bioavailability. The oral bioavailability of LF is poor and variable due to its limited aqueous solubility and P-gp mediated efflux occurring in small intestine. LF-SLNs were p...

journal_title：International journal of pharmaceutics

authors： Garg A,Bhalala K,Tomar DS,Wahajuddin

更新日期：2017-01-10 00:00:00

abstract：:Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630 as carriers. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffractio...

journal_title：International journal of pharmaceutics

authors： Lu Z,Yang Y,Covington RA,Bi YV,Dürig T,Ilies MA,Fassihi R

更新日期：2016-09-25 00:00:00

abstract：:The static electricity generated by triggering a piezo gas igniter is shown to cause electroporation of the skin to deliver antigen. Mice were immunized with chicken albumin by electroporation using a piezo gas igniter and in another experiment, the gas igniter was replaced by a power supply. In both the groups identi...

journal_title：International journal of pharmaceutics

authors： Upadhyay P

更新日期：2001-04-17 00:00:00

abstract：:Lung transplantation animal models have been well established and enabled the investigation of a variety of new pharmacotherapeutic strategies for prevention of lung allograft rejection. Direct administration of immunosuppressive agents to the lung is a commonly investigated approach; however, can prove challenging du...

journal_title：International journal of pharmaceutics

authors： Watts AB,Cline AM,Saad AR,Johnson SB,Peters JI,Williams RO 3rd

更新日期：2010-01-15 00:00:00

abstract：:Exosomes are lipid bilayer-enclosed vesicles of endosomal origin, which initially considered as garbage bins to dispose unwanted cellular components, but they are now emerged as an intercellular communication system involved in several physiological and pathological conditions. With the increasing understanding that t...

journal_title：International journal of pharmaceutics

authors： Liu Y,Wang Y,Lv Q,Li X

更新日期：2020-06-15 00:00:00

abstract：:An innovative bioadhesive patch intended primarily as a vulval drug delivery system and, specifically, as a means to deliver photosensitisers, or their prodrugs, for photodynamic purposes is described. The patch was formulated with a copolymer of methyl vinyl ether and maleic anhydride (PMVE/MA) as a bioadhesive matri...

journal_title：International journal of pharmaceutics

authors： McCarron PA,Donnelly RF,Zawislak A,Woolfson AD,Price JH,McClelland R

更新日期：2005-04-11 00:00:00

abstract：:During the freezing step of a typical freeze drying process, the temperature at which nucleation is induced is generally stochastically distributed, resulting in undesired within-batch heterogeneity. Controlled nucleation techniques have been developed to address this problem; these make it possible to trigger the for...

journal_title：International journal of pharmaceutics

authors： Arsiccio A,Matejtschuk P,Ezeajughi E,Riches-Duit A,Bullen A,Malik K,Raut S,Pisano R

更新日期：2020-05-30 00:00:00

abstract：:Remarkable efforts are currently devoted to the area of nanodiamonds (NDs) research due to their superior properties viz: biocompatibility, minute size, inert core, and tunable surface chemistry. The use of NDs for the delivery of anticancer drugs has been at the forefront of NDs applications owing to their ability to...

journal_title：International journal of pharmaceutics

authors： Ali MS,Metwally AA,Fahmy RH,Osman R

更新日期：2019-03-10 00:00:00

abstract：:Dextran nanobubbles were prepared with a dextran shell and a perfluoropentan core in which oxygen was stored. To increase the stability polyvinylpirrolidone was also added to the formulation as stabilizing agent. Rhodamine B was used as fluorescent marker to obtain fluorescent nanobubbles. The nanobubble formulations ...

journal_title：International journal of pharmaceutics

authors： Cavalli R,Bisazza A,Giustetto P,Civra A,Lembo D,Trotta G,Guiot C,Trotta M

更新日期：2009-11-03 00:00:00