Abstract：
:This work presents a study based on the preparation and characterization of drug-collagen hybrid materials. Materials used for obtaining drug-collagen hybrids were collagen type I (Coll) as matrix and fludarabine (F) and epirubicin (E) as hydrophilic active substances. After incorporation of drugs into Coll in different ratios, the obtained hybrid materials (Coll/F and Coll/E) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues (e.g. the treatment of breast, stomach, lung, colorectal or advanced ovarian cancer). The materials were characterized considering their composition (by XRD, FT-IR and DTA-TG) and their morphology (by SEM). The delivery of drug was assessed by UV-vis. The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Voicu G,Geanaliu-Nicolae RE,Pîrvan AA,Andronescu E,Iordache Fdoi
10.1016/j.ijpharm.2015.11.054subject
Has Abstractpub_date
2016-08-30 00:00:00pages
474-84issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(15)30401-4journal_volume
510pub_type
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