当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Plasticizer di(2-ethylhexyl)phthalate (DEHP) release in wet-primed extracorporeal membrane oxygenation (ECMO) circuits.

Plasticizer di(2-ethylhexyl)phthalate (DEHP) release in wet-primed extracorporeal membrane oxygenation (ECMO) circuits.

Abstract：

:A wet-primed ready-to-use extracorporeal membrane oxygenation (ECMO) circuit is used in some centres for rapid deployment of ECMO during cardiopulmonary resuscitation. Yet, the potential release of plasticizer di(2-ethylhexyl)phthalate (DEHP) from the polyvinyl chloride tubing in the circuit during storage is a concern. In this study, a high performance liquid chromatography method was used to determine the concentration of DEHP in the priming solution (Plasmalyte) from an ECMO circuit stored for up to 14 days at 8 degrees C. No accumulation of DEHP in the circulating fluid was detected. The results provide important information for centres where ECMO circuits are kept wet-primed prior to clinical use.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Han J,Beeton A,Long P,Karimova A,Robertson A,Cross N,Smith L,O'Callaghan M,Goldman A,Brown K,Tuleu C

doi

10.1016/j.ijpharm.2005.01.030

keywords:

subject

Has Abstract

pub_date

2005-04-27 00:00:00

pages

157-9

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(05)00101-8

journal_volume

294

pub_type

杂志文章

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