Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells.

abstract：:Recently, many people have developed rheumatoid arthritis (RA), and prednisolone (PD) is often used for treatment; however, long use and a large dose of PD can cause toxic side effects. In this study, in order to enhance the therapeutic effects and to suppress the toxic side effects, the conjugate (GC-SP) was prepared...

journal_title：International journal of pharmaceutics

authors： Onishi H,Saito Y,Sasatsu M,Machida Y

更新日期：2011-05-30 00:00:00

abstract：:Microspheres of roxithromycin with Eudragit S100 and silica were prepared by the emulsion solvent diffusion method to mask the bitter taste of the antibiotic. The effect of different polymers and drug-polymer ratios on the taste masking and the characteristics of the microspheres were investigated. It was found that E...

journal_title：International journal of pharmaceutics

authors： Gao Y,Cui FD,Guan Y,Yang L,Wang YS,Zhang LN

更新日期：2006-08-02 00:00:00

abstract：:The aim of the present work was to find a suitable method for the introduction of thiol functions on the surface of poly(DL-lactic acid) (PLA) nanoparticles. Three different approaches were investigated. The modification of the surface involves the activation of PLA carboxylic acid groups followed by the attack of a n...

journal_title：International journal of pharmaceutics

authors： Nobs L,Buchegger F,Gurny R,Allémann E

更新日期：2003-01-16 00:00:00

abstract：:Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI1.8) and subsequently investigated gene delivery features o...

journal_title：International journal of pharmaceutics

authors： Radmanesh F,Abandansari HS,Pahlavan S,Alikhani M,Karimi M,Rajabi S,Kazemi B,Baharvand H

更新日期：2019-06-30 00:00:00

abstract：:The aim of this work was to evaluate the potentiality to control the drug release of a new architecture of microparticles organized at the nanoscopic scale by assembling polymeric nanocapsules at the surface of drug-loaded xerogels. Xerogel was prepared by sol-gel method using sodium diclofenac, as hydrophilic drug mo...

journal_title：International journal of pharmaceutics

authors： da Fonseca LS,Silveira RP,Deboni AM,Benvenutti EV,Costa TM,Guterres SS,Pohlmann AR

更新日期：2008-06-24 00:00:00

abstract：:In this work, we present a novel approach for the development of models for prediction of aqueous solubility, based on the implementation of an algorithm for the automatic adjustment of descriptor's relative importance (AARI) in counter-propagation artificial neural networks (CPANN). Using this approach, the interpret...

journal_title：International journal of pharmaceutics

authors： Erić S,Kalinić M,Popović A,Zloh M,Kuzmanovski I

更新日期：2012-11-01 00:00:00

abstract：:This work presents a study based on the preparation and characterization of drug-collagen hybrid materials. Materials used for obtaining drug-collagen hybrids were collagen type I (Coll) as matrix and fludarabine (F) and epirubicin (E) as hydrophilic active substances. After incorporation of drugs into Coll in differe...

journal_title：International journal of pharmaceutics

authors： Voicu G,Geanaliu-Nicolae RE,Pîrvan AA,Andronescu E,Iordache F

更新日期：2016-08-30 00:00:00

abstract：:Effects of pH and co-solvents on the bio-mimetic artificial membrane permeation assay were investigated to determine the optimal conditions for the prediction of oral absorption. The permeability (P(am)) of 33 structurally diverse drugs to the PC/PE/PS/PI/CHO/1,7-octadiene membrane system (bio-mimetic lipid (BML) memb...

journal_title：International journal of pharmaceutics

authors： Sugano K,Hamada H,Machida M,Ushio H,Saitoh K,Terada K

更新日期：2001-10-09 00:00:00

abstract：:The purpose of the present study was to investigate the effect of secondary structure of three model polypeptides on their apparent permeability (P(app)) across a synthetic, microporous membrane. Poly-L-lysine (PL), poly-L-glutamate (PGlu), and poly-L-lysine-L-phenylalanine (1:1) (PLP) were selected because a solution...

journal_title：International journal of pharmaceutics

authors： Salamat-Miller N,Chittchang M,Mitra AK,Johnston TP

更新日期：2002-09-05 00:00:00

abstract：:Modification of recombinant proteins with polyethylene-glycol (PEG) can improve their pharmacokinetic properties, although their bioactivity may be reduced after PEGylation due to structural changes. In this study, simultaneous optimization of PEGylation efficiency and preserved bioactivity of recombinant human growth...

journal_title：International journal of pharmaceutics

authors： Karbasian M,Kouchakzadeh H,Anamaghi PN,Sefidbakht Y

更新日期：2019-02-25 00:00:00

abstract：:The objectives of this work were to develop a liposomal fasudil, an antivasospastic drug, as a possible means to deliver the encapsulated drug to the brain, and to characterize the stability of the liposomal formulation in vitro. Transmembrane electrochemical gradients of H+ or ammonium sulfate were created, and their...

journal_title：International journal of pharmaceutics

authors： Ishida T,Takanashi Y,Doi H,Yamamoto I,Kiwada H

更新日期：2002-01-31 00:00:00

abstract：:Water-insoluble suspensions of itraconazole and budesonide were sterically stabilized using nonionic polymers (poloxamer 188 or polysorbate 80) and probed for polymer-anion interactions by measuring changes in particle zeta potential. Anions comprising a range of functionalities and aqueous solubilities were examined....

journal_title：International journal of pharmaceutics

authors： Owen H,Graham S,Werling JO,Carter PW

更新日期：2009-02-23 00:00:00

abstract：:NLC topical formulation as an alternative to oral and parenteral (IM) delivery of artemether (ART), a poorly water-soluble drug was designed. A Phospholipon 85G-modified Gelucire 43/01 based NLC formulation containing 75% Transcutol was chosen from DSC studies and loaded with gradient concentration of ART (100-750 mg)...

journal_title：International journal of pharmaceutics

authors： Nnamani PO,Hansen S,Windbergs M,Lehr CM

更新日期：2014-12-30 00:00:00

abstract：:Amorphous nanoparticle suspensions of a poorly water-soluble drug, cyclosporine A, are produced by a new process, evaporative precipitation into aqueous solution (EPAS). The rapid evaporation of a heated organic solution of the drug, which is atomized into an aqueous solution, results in fast nucleation leading to nan...

journal_title：International journal of pharmaceutics

authors： Chen X,Young TJ,Sarkari M,Williams RO 3rd,Johnston KP

更新日期：2002-08-21 00:00:00

abstract：:An aqueous nanoparticle delivery system has been developed which employs the oppositely charged polymers polyethylenimine (PEI) and dextran sulfate (DS) with zinc as a stabilizer. It is found that the pH of PEI solutions, the weight ratio of the two polymers, and zinc sulfate concentrations all play significant roles ...

journal_title：International journal of pharmaceutics

authors： Tiyaboonchai W,Woiszwillo J,Sims RC,Middaugh CR

更新日期：2003-04-14 00:00:00

abstract：:Ciprofloxacin (CPX) physicochemical properties, mainly hydrophobicity and microspeciation, appear to be related with the ability of this drug to adsorb and diffuse through lipid environments. We have combined the information from fluorescence anisotropy, quenching and epifluorescence of phospholipid monolayers, to exp...

journal_title：International journal of pharmaceutics

authors： Hernández-Borrell J,Montero MT

更新日期：2003-02-18 00:00:00

abstract：:Insulin replacement therapy is integral to the management of type 1 diabetes, which is characterised by absolute insulin deficiency. Optimal glycaemic control, as assessed by glycated haemoglobin, and avoidance of hyper- and hypoglycaemic excursions have been shown to prevent diabetes-related complications. Insulin pu...

journal_title：International journal of pharmaceutics

authors： Bally L,Thabit H,Hovorka R

更新日期：2018-06-15 00:00:00

abstract：:The electrochemical reduction of ornidazole was studied at a glassy carbon electrode activated by applying a new pretreatment. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the solvent (aqueous media, mixed aqueous-organic systems) and surfactant was investigated. ...

journal_title：International journal of pharmaceutics

authors： Özkan SA,Senturk Z,Biryol I I

更新日期：1997-11-28 00:00:00

abstract：:The aim of this study was to develop a self-emulsifying drug delivery system (SEDDS) containing the glycopeptide antibiotic vancomycin (VAN) with improved intestinal mucosa permeating properties in order to increase oral drug absorption. VAN was effectively incorporated into SEDDS increasing the lipophilicity of the d...

journal_title：International journal of pharmaceutics

authors： Zaichik S,Steinbring C,Caliskan C,Bernkop-Schnürch A

更新日期：2019-01-10 00:00:00

abstract：:This study demonstrates the use of optical coherence tomography (OCT) to simultaneously characterize the roughness of the tablet core and coating of pharmaceutical tablets. OCT is a high resolution non-destructive and contactless imaging methodology to characterize structural properties of solid dosage forms. Besides ...

journal_title：International journal of pharmaceutics

authors： Markl D,Wahl P,Pichler H,Sacher S,Khinast JG

更新日期：2018-01-30 00:00:00

abstract：:Double-hydrophilic block copolymer composed of poly(N-vinylpyrrolidone) (PVP) and poly(styrene-alter-maleic anhydride) (PSMA) has been synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Poly(N-vinylpyrrolidone)-block-poly(styrene-alter-maleic anhydride) (PVP-b-PSMA) thus formed was ...

journal_title：International journal of pharmaceutics

authors： Luo Y,Wang A,Yuan J,Gao Q

更新日期：2009-06-05 00:00:00

abstract：:Prostaglandin E(1) (PGE1) shows various pharmacological activities including anti-inflammation. However, the rapid metabolization and inactivation of the intravenously administered PGE1 during the first passage through the lungs result in significant non-compliance in clinical trials which greatly limits its applicati...

journal_title：International journal of pharmaceutics

authors： Gao Y,Xu P,Chen L,Li Y

更新日期：2010-03-15 00:00:00

abstract：:A mathematical, mechanistic tablet film-coating model has been developed for pharmaceutical pan coating systems based on the mechanisms of atomisation, tablet bed movement and droplet drying with the main purpose of predicting tablet appearance quality. Two dimensionless quantities were used to characterise the produc...

journal_title：International journal of pharmaceutics

authors： Niblett D,Porter S,Reynolds G,Morgan T,Greenamoyer J,Hach R,Sido S,Karan K,Gabbott I

更新日期：2017-08-07 00:00:00

abstract：:Dextran nanobubbles were prepared with a dextran shell and a perfluoropentan core in which oxygen was stored. To increase the stability polyvinylpirrolidone was also added to the formulation as stabilizing agent. Rhodamine B was used as fluorescent marker to obtain fluorescent nanobubbles. The nanobubble formulations ...

journal_title：International journal of pharmaceutics

authors： Cavalli R,Bisazza A,Giustetto P,Civra A,Lembo D,Trotta G,Guiot C,Trotta M

更新日期：2009-11-03 00:00:00

abstract：:The application of cell-penetrating peptides (CPPs) for delivering various cargo molecules with biological functions into cells has gained much attention in recent years. However, the internalization mechanisms and delivery properties of CPP-cargo remains controversial. In this study, low- and high-molecular-weight ca...

journal_title：International journal of pharmaceutics

authors： Ma DX,Shi NQ,Qi XR

更新日期：2011-10-31 00:00:00

abstract：:Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler. In the present study we sought to examine the feasibility of producing nanoporous microparticles (NPMPs) of this hydrophilic material by adaptation of a spray drying process pre...

journal_title：International journal of pharmaceutics

authors： Nolan LM,Li J,Tajber L,Corrigan OI,Healy AM

更新日期：2011-02-28 00:00:00

abstract：:This work describes the pharmacokinetics of a novel carbamazepine nanoemulsion. The plasma concentration profiles were determined in beagle dogs after i.v. bolus administration of a 5 mg/kg carbamazepine nanoemulsion and compared to the corresponding carbamazepine/hydroxypropyl-beta-cyclodextrin complex solution. Both...

journal_title：International journal of pharmaceutics

authors： Kuminek G,Kratz JM,Ribeiro R,Kelmann RG,de Araújo BV,Teixeira HF,Simões CM,Koester LS

更新日期：2009-08-13 00:00:00

abstract：:Flash nanoprecipitation (FNP) is a controlled antisolvent precipitation process that has proven effective for consistent production of drug nanoparticles with a defined mean particle size and narrow particle size distribution. However, physical instability of the generated nanoparticles remains a major challenge in th...

journal_title：International journal of pharmaceutics

authors： Wan KY,Wong KW,Chow AHL,Chow SF

更新日期：2018-05-05 00:00:00

abstract：:It is important to quantify amorphous solid in active pharmaceutical ingredients (API) of formulations to guarantee high-quality pharmaceutical products. In this study, we aimed to quantify amorphous solid in API by transmission Raman spectroscopy (TRS) and transmission near-infra-red spectroscopy (NIRS). To quantify ...

journal_title：International journal of pharmaceutics

authors： Terada H,Hattori Y,Sasaki T,Otsuka M

更新日期：2019-06-30 00:00:00

abstract：:We determined whether a single intratracheal and subcutaneous administration of biocompatible and biodegradable vasoactive intestinal peptide self-associated with sterically stabilized liposomes (VIP-SSL) normalizes mean arterial pressure (MAP) in spontaneously hypertensive hamsters (SHH). We found that VIP-SSL (0.1 n...

journal_title：International journal of pharmaceutics

authors： Rubinstein I,Ikezaki H,Onyüksel H

更新日期：2006-06-19 00:00:00