Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in spontaneously hypertensive hamsters.

abstract：:Topical iodine forms are used for infected and necrotic pressure ulcers. Despite antimicrobial advantages several potential disadvantages were observed with controversial results. To clarify the controversy, the reactivity of povidone-iodine (PI) sugar ointment and cadexomer-iodine (CI) ointment toward biological comp...

journal_title：International journal of pharmaceutics

authors： Noda Y,Fujii K,Fujii S

更新日期：2009-05-08 00:00:00

abstract：:The aim of the present work was to study the influence of surface hydrophilicity of biodegradable polymeric nanoparticles on cellular uptake by Caco-2 cells. Poly(D,L-lactide-co-glycolide acid) particles loaded with a fluorescent dye, 3,3'-dioctadecyloxacarbo-cyanine perchlorate (DiO), were prepared by the emulsion-ev...

journal_title：International journal of pharmaceutics

authors： Gaumet M,Gurny R,Delie F

更新日期：2010-05-05 00:00:00

abstract：:Biocompatible and thermosensitive poly(organophosphazenes) with a lower critical solution temperature (LCST) below body temperature have been designed with the aim for the local delivery of peptide and protein drugs. These polymers could be synthesized by introducing short chain tri- or tetraethylene glycol as a hydro...

journal_title：International journal of pharmaceutics

authors： Seong JY,Jun YJ,Kim BM,Park YM,Sohn YS

更新日期：2006-05-11 00:00:00

abstract：:The number of active pharmaceutical substances having high therapeutic potential but low water solubility is constantly increasing, making it difficult to formulate these compounds as oral dosage forms. The solubility and dissolution rate, and thus potentially the bioavailability, of these poorly water-soluble drugs c...

journal_title：International journal of pharmaceutics

authors： Laitinen R,Löbmann K,Strachan CJ,Grohganz H,Rades T

更新日期：2013-08-30 00:00:00

abstract：:An increased number of amorphous formulations of poorly water soluble drugs are being introduced into the market due to their higher transient solubility and thus faster absorption and higher bioavailability. While most amorphous drug products contain a single drug substance, there is a growing trend towards co-formul...

journal_title：International journal of pharmaceutics

authors： Trasi NS,Taylor LS

更新日期：2015-12-30 00:00:00

abstract：:Dermal administration of different macromolecules, such as nucleic acids, remains a real challenge because of the difficulty of crossing the main skin barrier, the stratum corneum (SC). To overcome this barrier, the use of deformable lipid-based nanovectors were developed to increase topical penetration through the SC...

journal_title：International journal of pharmaceutics

authors： Bellefroid C,Lechanteur A,Evrard B,Mottet D,Debacq-Chainiaux F,Piel G

更新日期：2019-12-15 00:00:00

abstract：:Epirubicin (EPI) is a P-gp substrate antracycline analogue which elicits poor oral bioavailability. In the present work, EPI loaded poly-lactide-co-glycolic acid nanoparticles (PLGA-NPs) were prepared by double emulsion approach and superficially decorated with polyethylene glycol (EPI-PNPs) and mannosamine (EPI-MNPs)...

journal_title：International journal of pharmaceutics

authors： Tariq M,Alam MA,Singh AT,Panda AK,Talegaonkar S

更新日期：2016-03-30 00:00:00

abstract：:Flurbiprofen loaded rigid and elastic vesicles comprising the bilayer-forming surfactant sucrose-ester laurate were prepared by the film rehydration and extrusion method. The charge-inducing agent sodium dodecyl sulfate, and the micelle-forming surfactants, sorbitan monolaurate, polyethylene glycol monolaurate, and po...

journal_title：International journal of pharmaceutics

authors： Uchino T,Matsumoto Y,Murata A,Oka T,Miyazaki Y,Kagawa Y

更新日期：2014-04-10 00:00:00

abstract：:The aim of this study was to assess the in vitro stability of ranitidine to colonic bacteria by utilising a batch culture fermentation system to simulate the conditions of the colon. Three quantities of ranitidine, 100, 200 and 500 mg, in the form of the hydrochloride salt, were introduced into individual 100 ml ferme...

journal_title：International journal of pharmaceutics

authors： Basit AW,Lacey LF

更新日期：2001-10-04 00:00:00

abstract：:The pharmacokinetics of NS-49, a newly developed phenethylamine class alpha(1A)-adrenoceptor agonist, was investigated in rats, rabbits, and dogs given intravenous and oral doses that have little effect on the renal blood flow rate (approximating the range of clinical doses). A three-compartment open model adequately ...

journal_title：International journal of pharmaceutics

authors： Mukai H,Watanabe S,Tsuchida K,Morino A

更新日期：1999-09-20 00:00:00

abstract：:Drug delivery using suitable polymeric devices has gathered momentum in the recent years due to their remarkable properties. The versatility of polymeric materials makes them reliable candidates for site targeted drug release. Among them biodegradable sutures has received considerable attention because they offer grea...

journal_title：International journal of pharmaceutics

authors： Joseph B,George A,Gopi S,Kalarikkal N,Thomas S

更新日期：2017-05-30 00:00:00

abstract：:The present study puts forward a miniaturized high-throughput platform to understand influence of excipient selection and processing on the stability of a given drug compound. Four model drugs (sodium naproxen, theophylline, amlodipine besylate and nitrofurantoin) and ten different excipients were selected. Binary phy...

journal_title：International journal of pharmaceutics

authors： Raijada D,Cornett C,Rantanen J

更新日期：2013-08-30 00:00:00

abstract：:Transferosomes, also known as transfersomes, are ultradeformable vesicles for transdermal applications consisting of a lipid bilayer with phospholipids and an edge activator and an ethanol/aqueous core. Depending on the lipophilicity of the active substance, it can be encapsulated within the core or amongst the lipid ...

journal_title：International journal of pharmaceutics

authors： Fernández-García R,Lalatsa A,Statts L,Bolás-Fernández F,Ballesteros MP,Serrano DR

更新日期：2020-01-05 00:00:00

abstract：:The effect of different formulation factors (lipid type, cholesterol, charge, internal buffer capacity, drug-to-lipid incubation ratio) on the encapsulation efficiency and size of primaquine liposomes (SUV's) in response to a pH gradient was investigated by a fractional factorial screen ing design. Three of the factor...

journal_title：International journal of pharmaceutics

authors： Stensrud G,Sande SA,Kristensen S,Smistad G

更新日期：2000-04-05 00:00:00

abstract：:Combination strategy involving cyclodextrin (CD) complexation and liposomal system was investigated for Paclitaxel (PTX) to improve loading. Complexation was done using 2,6-di-O-methylbetacyclodextrin (DMβCD). Sterically stabilized double loaded PEGylated liposomes (DLPLs) containing PTX and PTX-DMβCD complex were pre...

journal_title：International journal of pharmaceutics

authors： Bhatt P,Lalani R,Vhora I,Patil S,Amrutiya J,Misra A,Mashru R

更新日期：2018-01-30 00:00:00

abstract：:Thermal isoeffect dose (TID) is a widely applied concept to evaluate the safety of medical devices that can expose patients to heat. However, it has rarely been used in photothermal therapy (PTT), where nanoparticles are used as light absorbers. Utilizing TID in an appropriate way would make it feasible to compare the...

journal_title：International journal of pharmaceutics

authors： Happonen E,Tamarov K,Martikainen MV,Ketola K,Roponen M,Lehto VP,Xu W

更新日期：2020-09-25 00:00:00

abstract：:The combination of essential oils (EOs) with antibiotics provides a promising strategy towards combating resistant bacteria. We have selected a mixture of 3 major components extracted from EOs: carvacrol (oregano oil), eugenol (clove oil) and cinnamaldehyde (cinnamon oil). These compounds were successfully encapsulate...

journal_title：International journal of pharmaceutics

authors： Valcourt C,Saulnier P,Umerska A,Zanelli MP,Montagu A,Rossines E,Joly-Guillou ML

更新日期：2016-02-10 00:00:00

abstract：:The need for stringent temperature control provides significant challenges to pharmaceutical distributors operating in all sectors of the industry. Products with a frozen storage label requirement can be significantly problematic. This study aimed to provide evidence of robust and reproducible frozen shipment arrangem...

journal_title：International journal of pharmaceutics

authors： Elliott MA,Halbert GW

更新日期：2008-01-04 00:00:00

abstract：:The purpose of this research was to study isomalt as a protein-stabilizing excipient with lactate dehydrogenase (LDH) during freeze-drying and subsequent storage and compare it to sucrose, a standard freeze-drying excipient. Four different diastereomer mixtures of isomalt were studied. The stability of the protein was...

journal_title：International journal of pharmaceutics

authors： Tuderman AK,Strachan CJ,Juppo AM

更新日期：2018-03-01 00:00:00

abstract：:In current study, a self-nanoemulsifying drug delivery system (SNEDDS) of persimmon (Diospyros kaki) leaf extract (PLE) was developed and characterized to compare its in vitro dissolution and relative bioavailability with commercially available tablets (Naoxinqing tablets). Pseudo-ternary phase diagrams were construct...

journal_title：International journal of pharmaceutics

authors： Li W,Yi S,Wang Z,Chen S,Xin S,Xie J,Zhao C

更新日期：2011-11-25 00:00:00

abstract：:The use of non-linear mixed effects models to describe dissolution data has been evaluated. A theoretical part is included to introduce this approach to scientists who are not familiar with this type of statistics. The standard settings of the statistical software package (S-plus) are used as much as possible. Several...

journal_title：International journal of pharmaceutics

authors： Adams E,Coomans D,Smeyers-Verbeke J,Massart DL

更新日期：2002-06-20 00:00:00

abstract：:The aim of present study was to develop folate appended PEGylated solid lipid nanoparticles(SLNs) of paclitaxel(FPS) and artemether(FAS). The SLNs were prepared by employing high pressure homogenization technique. The results of MTT assays revealed better cytotoxicity of FPS when given in combination with FAS on human...

journal_title：International journal of pharmaceutics

authors： Khatri H,Chokshi N,Rawal S,Patel BM,Badanthadka M,Patel MM

更新日期：2020-06-15 00:00:00

abstract：:Water-in-oil-in-water (w/o/w) double emulsions are potential for enhancing oral bioavailability of drugs with high solubility and low permeability, but their industrial application is limited due to the instability. Herein, we developed a novel formulation, self-double-emulsifying drug delivery systems (SDEDDS) by for...

journal_title：International journal of pharmaceutics

authors： Qi X,Wang L,Zhu J,Hu Z,Zhang J

更新日期：2011-05-16 00:00:00

abstract：:Low-frequency ultrasound application is known to increase the skin's permeability to large molecules such as vaccines, and to enable transcutaneous immunisation. Sodium dodecyl sulphate (SDS) - a skin irritant - is often included in the coupling medium at 1% (w/v), as this has been found to enhance skin permeability. ...

journal_title：International journal of pharmaceutics

authors： Dahlan A,Alpar HO,Stickings P,Sesardic D,Murdan S

更新日期：2009-02-23 00:00:00

abstract：:The purpose of this study was to develop a nanosuspension of a poorly soluble drug by nanomilling process using wet media milling to achieve superior in vitro dissolution and high in vivo exposure in pharmacokinetic studies. A promising nanosuspension was developed with Vitamin E TPGS based formulation with particle s...

journal_title：International journal of pharmaceutics

authors： Ghosh I,Bose S,Vippagunta R,Harmon F

更新日期：2011-05-16 00:00:00

abstract：:Peptides and polypeptides have important pharmacological properties but only a limited number have been exploited as therapeutics because of problems related to their delivery. Most of these drugs require a parenteral delivery system which introduces the problems of pain, possible infection, and expertise required to ...

journal_title：International journal of pharmaceutics

authors： Tas C,Mansoor S,Kalluri H,Zarnitsyn VG,Choi SO,Banga AK,Prausnitz MR

更新日期：2012-02-28 00:00:00

abstract：:We studied skin occlusion effects in vitro and in vivo on local and systemic delivery of ketoprofen across the organ, using the drug in a conventional non-occlusive topical gel (Togal Mobil-Gel), an occlusive tape (Mohrus), and the new targeted analgesic (Diractin), comprising ultradeformable, hydrophilic carriers in ...

journal_title：International journal of pharmaceutics

authors： Cevc G,Mazgareanu S,Rother M,Vierl U

更新日期：2008-07-09 00:00:00

abstract：:Nanoparticles of polymeric complexes made of hyaluronic acid and polyarginine were investigated for the encapsulation of the cationic hydrophilic drug pentamidine isethionate. The interaction between the anionic hyaluronic acid and the cationic pentamidine resulting in the formation of polyelectrolyte complexes was fi...

journal_title：International journal of pharmaceutics

authors： Carton F,Chevalier Y,Nicoletti L,Tarnowska M,Stella B,Arpicco S,Malatesta M,Jordheim LP,Briançon S,Lollo G

更新日期：2019-09-10 00:00:00

abstract：:Development of an oral docetaxel formulation has been hindered mainly due to its poor solubility and oral bioavailability. The aim of this study was to develop poloxamer F68/P85-based solid dispersions (SDs) for the oral delivery of docetaxel and investigate their in vivo pharmacokinetic impacts on the systemic absorp...

journal_title：International journal of pharmaceutics

authors： Song CK,Yoon IS,Kim DD

更新日期：2016-06-30 00:00:00

abstract：:To enhance the stability of the anticancer drug gemcitabine (2'-deoxy-2',2'-difluorocytidine), it was conjugated to poly-l-glutamic acid (PG-H) via a carbodiimide reaction. The synthesised poly-l-glutamic acid-gemcitabine (PG-G) was purified and characterised by using SDS-PAGE to estimate its molecular weight, HPLC to...

journal_title：International journal of pharmaceutics

authors： Kiew LV,Cheong SK,Sidik K,Chung LY

更新日期：2010-05-31 00:00:00