Abstract:
:The combination of essential oils (EOs) with antibiotics provides a promising strategy towards combating resistant bacteria. We have selected a mixture of 3 major components extracted from EOs: carvacrol (oregano oil), eugenol (clove oil) and cinnamaldehyde (cinnamon oil). These compounds were successfully encapsulated within lipid nanocapsules (LNCs). The EOs-loaded LNCs were characterised by a noticeably high drug loading of 20% and a very small particle diameter of 114nm. The in vitro interactions between EOs-loaded LNCs and doxycycline were examined via checkerboard titration and time-kill assay against 5 Gram-negative strains: Acinetobacter baumannii SAN, A. baumannii RCH, Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa. No growth inhibition interactions were found between EOs-loaded LNCs and doxycycline (FIC index between 0.7 and 1.30). However, when bactericidal effects were considered, a synergistic interaction was observed (FBC index equal to 0.5) against all tested strains. A synergistic effect was also observed in time-kill assay (a difference of at least 3 log between the combination and the most active agent alone). Scanning electron microscopy (SEM) was used to visualise the changes in the bacterial membrane. The holes in bacterial envelope and leakage of cellular contents were observed in SE micrographs after exposure to the EOs-LNCs and the doxycycline combination.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Valcourt C,Saulnier P,Umerska A,Zanelli MP,Montagu A,Rossines E,Joly-Guillou MLdoi
10.1016/j.ijpharm.2015.11.042subject
Has Abstractpub_date
2016-02-10 00:00:00pages
23-31issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(15)30388-4journal_volume
498pub_type
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2015.05.010
更新日期:2015-07-15 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2007.02.034
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journal_title:International journal of pharmaceutics
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2019-07-20 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2015.06.033
更新日期:2015-08-01 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2017.12.026
更新日期:2018-02-15 00:00:00