Abstract:
:The aim of this work was to evaluate the potentiality to control the drug release of a new architecture of microparticles organized at the nanoscopic scale by assembling polymeric nanocapsules at the surface of drug-loaded xerogels. Xerogel was prepared by sol-gel method using sodium diclofenac, as hydrophilic drug model, and coated by spray-drying. After coating, the surface areas decreased from 82 to 28 m(2)/g, the encapsulation efficiency was 71% and SEM analysis showed irregular microparticles coated by the nanocapsules. Formulation showed satisfactory gastro-resistance presenting drug release lower than 3% (60 min) in acid medium. In water, the pure drug dissolved 92% after 5 min, uncoated drug-loaded xerogel released 60% and nanocapsule coated drug-loaded xerogel 36%. After 60 min, uncoated drug-loaded xerogel released 82% and nanocapsule coated drug-loaded xerogel 62%. In conclusion, the new system was able to control the release of the hydrophilic drug model.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
da Fonseca LS,Silveira RP,Deboni AM,Benvenutti EV,Costa TM,Guterres SS,Pohlmann ARdoi
10.1016/j.ijpharm.2008.02.005subject
Has Abstractpub_date
2008-06-24 00:00:00pages
292-5issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(08)00118-Xjournal_volume
358pub_type
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