当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Liquid crystalline drug delivery vehicles for oral and IV/subcutaneous administration of poorly soluble (and soluble) drugs.

Liquid crystalline drug delivery vehicles for oral and IV/subcutaneous administration of poorly soluble (and soluble) drugs.

Abstract：

:Poorly soluble drug molecules often have low bioavailability issues and absorption problems in the clinical setting. As the number of poorly soluble drugs increases from discovery, developing technologies to enhance their solubility, while also controlling their release is one of the many challenges facing the pharmaceutical industry today. Liquid crystalline systems, nanoparticulate or macro-matrix, self-assemble in the presence of an aqueous environment and can provide a solubility enhancement, while also controlling the drug release rate. This review examines the fundamentals of liquid crystalline systems through the representative literature, concluding with examples of liquid crystalline systems in clinical trials development. The review focus is on the potential of utilizing liquid crystalline systems for poorly soluble drugs, in the areas of oral delivery and IV/subcutaneous, followed by water soluble molecules. Key considerations in utilizing liquid crystalline systems advantages while also discussing potential areas of key research that may be needed will be highlighted.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Otte A,Soh BK,Yoon G,Park K

doi

10.1016/j.ijpharm.2018.01.037

subject

Has Abstract

pub_date

2018-03-25 00:00:00

pages

175-183

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(18)30056-5

journal_volume

539

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Interfacial elastic relaxation during the ejection of bi-layered tablets.

    abstract：:The predilection of a bi-layered tablet to fail in the interface region after its initial formation in the compaction process reduces its practicality as a choice for controlled release solid drug delivery system. Hence, a fundamental appreciation of the governing mechanism that causes the weakening of the interfacial...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.11.031

    authors： Anuar MS,Briscoe BJ

    更新日期：2010-03-15 00:00:00

  • Incorporating platelet-rich plasma into coaxial electrospun nanofibers for bone tissue engineering.

    abstract：:Platelet-rich plasma (PRP) is used in therapy for bone tissue repair because an abundance of osteogenesis-related growth factors can be released from the concentrated platelets. However, its clinical use is limited because growth factors, temporally released from PRP, are degraded rapidly. This study aimed to incorpor...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.06.020

    authors： Cheng G,Ma X,Li J,Cheng Y,Cao Y,Wang Z,Shi X,Du Y,Deng H,Li Z

    更新日期：2018-08-25 00:00:00

  • A novel image analysis methodology for online monitoring of nucleation and crystal growth during solid state phase transformations.

    abstract：:This study focuses on the development of an automated image analysis method to extract information on nucleation and crystal growth from polarized light micrographs. Using the developed image analysis method, four parameters related to nucleation and crystal growth could be extracted from the images. These parameters ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.04.074

    authors： Wu JX,Xia D,van den Berg F,Amigo JM,Rades T,Yang M,Rantanen J

    更新日期：2012-08-20 00:00:00

  • Enhanced bioavailability of buspirone hydrochloride via cup and core buccal tablets: formulation and in vitro/in vivo evaluation.

    abstract：:This work aims to prepare sustained release buccal mucoadhesive tablets of buspirone hydrochloride (BH) to improve its systemic bioavailability. The tablets were prepared according to 5×3 factorial design where polymer type was set at five levels (carbopol, hydroxypropyl methylcellulose, sodium alginate, sodium carbox...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijpharm.2014.01.003

    authors： Kassem MA,Elmeshad AN,Fares AR

    更新日期：2014-03-10 00:00:00

  • Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts.

    abstract：:While the heightened tumor accumulation of systemically administered nanomedicines relative to conventional chemotherapeutic agents has been well established, corresponding improvements in therapeutic efficacy have often been incommensurate. This observation may be attributed to the limited exposure of cancer cells to...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.01.010

    authors： Mikhail AS,Eetezadi S,Ekdawi SN,Stewart J,Allen C

    更新日期：2014-04-10 00:00:00

  • Radioprotective effect of self-assembled low molecular weight Fucoidan-Chitosan nanoparticles.

    abstract：:Fucoidan, a sulphated polysaccharide, plays a vital role in reducing cellular oxidative damage by exerting potential antioxidant activity. However, because of the negative surface charges of oligofucoidan, it shows poor oral intestinal absorption. To overcome this drawback, the oligofucoidan polysaccharides self-assem...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119161

    authors： Wu SY,Parasuraman V,Hsieh-Chih-Tsai,Arunagiri V,Gunaseelan S,Chou HY,Anbazhagan R,Lai JY,Prasad N R

    更新日期：2020-04-15 00:00:00

  • Enhanced solid-state stability of amorphous ibrutinib formulations prepared by hot-melt extrusion.

    abstract：:One of the applications of Hot-Melt Extrusion (HME) is the stabilization of amorphous drugs through its incorporation into polymeric blends in the form of Amorphous Solid Dispersions (ASDs). In this study, HME was applied to solve a real problem in the development of an ibrutinib product, stabilizing the amorphous for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119156

    authors： Simões MF,Nogueira BA,Tabanez AM,Fausto R,Pinto RMA,Simões S

    更新日期：2020-04-15 00:00:00

  • Evaluation of HO-1-u-1 cell line as an in vitro model for sublingual drug delivery involving passive diffusion--Initial validation studies.

    abstract：:The aim of this study was to provide preliminary validation of a new sublingual mucosal cell line (HO-1-u-1) for use as in vitro sublingual drug delivery screening of compounds involving passive diffusion. HO-1-u-1 cells were seeded on cell culture inserts. The ultrastructure and integrity of cell layers, inter-passag...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.10.012

    authors： Wang Y,Zuo Z,Lee KK,Chow MS

    更新日期：2007-04-04 00:00:00

  • Formulation and in-vitro evaluation of directly compressed controlled release matrices of Losartan Potassium using Ethocel Grade 100 as rate retarding agent.

    abstract：:Current study was aimed to develop 200mg controlled release matrix tablets of Losartan Potassium using Ethocel 100 Premium and Ethocel 100 FP Premium as rate controlling polymer. In-vitro studies were performed according to USP Method-I in phosphate buffer (PH 6.8) using pharma test dissolution apparatus. The temperat...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.051

    authors： Khan KA,Khan GM,Zeeshan Danish M,Akhlaq,Khan H,Rehman F,Mehsud S

    更新日期：2015-12-30 00:00:00

  • A novel administration route for edaravone: I. Effects of metabolic inhibitors on skin permeability of edaravone.

    abstract：:We examined the effects of metabolic inhibitors on skin permeation of edaravone. SKF-525A, diclofenac sodium (DIC) and indomethacin (IND) were added to supernatant fluid (SF) of hairless rat (HR) skin homogenate. L-Cysteine (L-Cys) and benzotriazole (BTA), as pharmaceutical additives, were added to HR skin homogenate ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.12.038

    authors： Sato T,Mizuno K,Ishii F

    更新日期：2009-05-08 00:00:00

  • Inorganic-polymer nanohybrid carrier for delivery of a poorly-soluble drug, ursodeoxycholic acid.

    abstract：:Delivery of poorly soluble drugs has been problematic due to its low absorption profile and bioavailability. In this work, ursodeoxycholic acid (UDCA), a poorly-soluble drug, was intercalated into inorganic nanovehicle, layered double hydroxides (LDHs), with a molecular level to enhance its solubility in biological fl...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.09.039

    authors： Choi G,Lee JH,Oh YJ,Choy YB,Park MC,Chang HC,Choy JH

    更新日期：2010-12-15 00:00:00

  • Correlation of solid dosage porosity and tensile strength with acoustically extracted mechanical properties.

    abstract：:Currently, the compressed tablet and its oral administration is the most popular drug delivery modality in medicine. The accurate porosity and tensile strength characterization of a tablet design is vital for predicting its performance such as disintegration, dissolution, and drug-release efficiency upon administratio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.03.018

    authors： Xu X,Mack C,Cleland ZJ,Vallabh CKP,Dave VS,Cetinkaya C

    更新日期：2018-05-05 00:00:00

  • Application of a chromatic confocal measurement system as new approach for in-line wet film thickness determination in continuous oral film manufacturing processes.

    abstract：:The key parameter of the oral film production process is the wet film thickness since it regulates the active pharmaceutical ingredient (API) content of the finished product. There is no general recommendation on how to adjust the gap height of the coating knife during the film manufacturing process to obtain the targ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.09.028

    authors： Niese S,Quodbach J

    更新日期：2018-11-15 00:00:00

  • Development of Ussing model coupled with artificial membrane for predicting intestinal absorption mechanisms of drugs.

    abstract：:The absorption mechanisms of drugs play an important role on development and various application of drugs. However, the present methods of absorption mechanisms are not perfect enough. Hence, exploring a novel method to accurately predict the absorption mechanisms is necessary. In this study, we developed an Ussing mo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119170

    authors： Huang S,Huang Y,Yin X,Wang D,Xiang W,Wang M,Xia Z

    更新日期：2020-04-15 00:00:00

  • Hemocompatibility of poly(ɛ-caprolactone) lipid-core nanocapsules stabilized with polysorbate 80-lecithin and uncoated or coated with chitosan.

    abstract：:The hemocompatibility of nanoparticles is of critical importance for their systemic administration as drug delivery systems. Formulations of lipid-core nanocapsules, stabilized with polysorbate 80-lecithin and uncoated or coated with chitosan (LNC and LNC-CS), were prepared and characterized by laser diffraction (D[4,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.01.051

    authors： Bender EA,Adorne MD,Colomé LM,Abdalla DSP,Guterres SS,Pohlmann AR

    更新日期：2012-04-15 00:00:00

  • Transdermal delivery of flurbiprofen from surfactant-based vesicles: particle characterization and the effect of water on in vitro transport.

    abstract：:Flurbiprofen loaded rigid and elastic vesicles comprising the bilayer-forming surfactant sucrose-ester laurate were prepared by the film rehydration and extrusion method. The charge-inducing agent sodium dodecyl sulfate, and the micelle-forming surfactants, sorbitan monolaurate, polyethylene glycol monolaurate, and po...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.12.051

    authors： Uchino T,Matsumoto Y,Murata A,Oka T,Miyazaki Y,Kagawa Y

    更新日期：2014-04-10 00:00:00

  • New prospective in treatment of Parkinson's disease: studies on permeation of ropinirole through buccal mucosa.

    abstract：:The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic conditions. Ropinirole, widely used in treatment of motor fluctuations of...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.022

    authors： De Caro V,Giandalia G,Siragusa MG,Sutera FM,Giannola LI

    更新日期：2012-06-15 00:00:00

  • Xanthan and galactomannan (from M. scabrella) matrix tablets for oral controlled delivery of theophylline.

    abstract：:Directly compressed theophylline tablets, containing commercial xanthan (X) (Keltrol) and a highly hydrophilic galactomannan (G) from the seeds of Mimosa scabrella (a brazilian leguminous tree called bracatinga) as release-controlling agents, were obtained. Gums were used at 4, 8, 12.5 and 25% (w/w), either alone or i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.02.007

    authors： Vendruscolo CW,Andreazza IF,Ganter JL,Ferrero C,Bresolin TM

    更新日期：2005-05-30 00:00:00

  • Application of continuous twin screw granulation for the metformin hydrochloride extended release formulation.

    abstract：:This study focuses on evaluating the potential of transferring from a batch process to continuous process for manufacturing of the extended release formulation. Metformin hydrochloride (HCl) was used in the model formulation which was intended to contain the high amount of hydrophilic drug. The effects of barrel tempe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.07.019

    authors： Kim SH,Hwang KM,Cho CH,Nguyen TT,Seok SH,Hwang KM,Kim JY,Park CW,Rhee YS,Park ES

    更新日期：2017-08-30 00:00:00

  • Mucoadhesive olaminosomes: A novel prolonged release nanocarrier of agomelatine for the treatment of ocular hypertension.

    abstract：:Mucoadhesive olaminosomes are novel nanocarriers designed to control agomelatine release and enhance its bioavailability. Olaminosomes were prepared using oleic acid, oleylamine and sorbitan monooleate adopting thin film hydration technique. Chitosan HCl was added to impart the mucoadhesive properties to the olaminoso...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.070

    authors： Abd-Elsalam WH,ElKasabgy NA

    更新日期：2019-04-05 00:00:00

  • The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers.

    abstract：:Previous in vivo studies using PEG 400 showed an enhancement in the bioavailability of ranitidine. This study investigated the effect of PEG 200, 300 and 400 on ranitidine transport across Caco-2 cells. The effect of PEG polymers (20%, v/v) on the bi-directional flux of (3)H-ranitidine across Caco-2 cell monolayers wa...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.02.059

    authors： Ashiru-Oredope DA,Patel N,Forbes B,Patel R,Basit AW

    更新日期：2011-05-16 00:00:00

  • Dextrin-trypsin and ST-HPMA-trypsin conjugates: enzyme activity, autolysis and thermal stability.

    abstract：:Using monomethoxy poly(ethylene glycol) (mPEG)-trypsin conjugates we recently showed that both PEG molecular weight (1100-5000 g/mol) and linker chemistry affect the rate of protein autolysis and thermal stability. These important factors are often overlooked but they can guide the early choice of optimal polymer/chem...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.02.008

    authors： Treetharnmathurot B,Dieudonné L,Ferguson EL,Schmaljohann D,Duncan R,Wiwattanapatapee R

    更新日期：2009-05-21 00:00:00

  • 1H NMR quantification of spray dried and spray freeze-dried saccharide carriers in dry powder inhaler formulations.

    abstract：:Quantitative analysis using proton NMR (1H qNMR) has been employed in various areas such as pharmaceutical analysis (e.g., dissolution study), vaccines, natural products analysis, metabolites, and macrolide antibiotics in agriculture industry. However, it is not routinely used in the quantification of saccharides in d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.03.030

    authors： Babenko M,Peron JR,Kaialy W,Calabrese G,Alany RG,ElShaer A

    更新日期：2019-06-10 00:00:00

  • The influence of plate design on the properties of pellets produced by extrusion and spheronization.

    abstract：:The aim of this work was to produce pellets using a standard formulation by means of extrusion and spheronization. Three different spheroniser friction plate patterns (i.e. cross-hatch, radial, striated edge pattern) have been used in order to investigate whether the plate pattern affects physical properties of the pe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.05.050

    authors： Michie H,Podczeck F,Newton JM

    更新日期：2012-09-15 00:00:00

  • In-line monitoring of pellet coating thickness growth by means of visual imaging.

    abstract：:Coating thickness is the most important attribute of coated pharmaceutical pellets as it directly affects release profiles and stability of the drug. Quality control of the coating process of pharmaceutical pellets is thus of utmost importance for assuring the desired end product characteristics. A visual imaging tech...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.04.066

    authors： Oman Kadunc N,Sibanc R,Dreu R,Likar B,Tomaževič D

    更新日期：2014-08-15 00:00:00

  • Diclofenac-β-cyclodextrin for colonic drug targeting: In vivo performance in rats.

    abstract：:The aim of this in vivo study was to assess the ability of the prodrug conjugate diclofenac-β-cyclodextrin to release diclofenac in the colon following oral administration, using sulfapyridine (a metabolite of sulfasalazine) as a marker of colonic absorption. Two groups of rats were used; the test rats received a susp...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.01.024

    authors： Vieira AC,Serra AC,Veiga FJ,Gonsalves AM,Basit AW,Murdan S

    更新日期：2016-03-16 00:00:00

  • Phospholipid components of the synthetic pulmonary surfactant CHF5633 probed by fluorescence spectroscopy.

    abstract：:CHF5633 (Chiesi Farmaceutici, Italy) is a synthetic pulmonary surfactant currently under clinical development for the treatment of Respiratory Distress Syndrome in premature infants. The product is composed of phospholipids in liposomal organization, together with two peptide analogues of human surfactant proteins B a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.10.045

    authors： Faggiano S,Ronda L,Raboni S,Sartor F,Cavatorta V,Sgarbi E,Caivano G,Pertile M,Mozzarelli A

    更新日期：2018-12-20 00:00:00

  • Influence of ethanol on aspirin release from hypromellose matrices.

    abstract：:Release profiles of aspirin from hypromellose matrices in hydro-ethanolic media were studied. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however, dose dumping of aspirin did not occur. An initial rapid release was observed in m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.09.055

    authors： Roberts M,Cespi M,Ford JL,Dyas AM,Downing J,Martini LG,Crowley PJ

    更新日期：2007-03-06 00:00:00

  • Elaboration and evaluation of alginate foam scaffolds for soft tissue engineering.

    abstract：:Controlling microarchitecture in polymer scaffolds is a priority in material design for soft tissue applications. This paper reports for the first time the elaboration of alginate foam-based scaffolds for mesenchymal stem cell (MSC) delivery and a comparative study of various surfactants on the final device performanc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.02.060

    authors： Ceccaldi C,Bushkalova R,Cussac D,Duployer B,Tenailleau C,Bourin P,Parini A,Sallerin B,Girod Fullana S

    更新日期：2017-05-30 00:00:00

  • Sterilization of implantable polymer-based medical devices: A review.

    abstract：:This review article is focused on the sterilization techniques used for polymer-based implantable medical devices as well as the regulatory aspects governing sterile medical devices. Polymeric materials are increasingly used in implantable devices due to their biodegradable and biocompatible nature. Patients and medic...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.12.003

    authors： Tipnis NP,Burgess DJ

    更新日期：2018-06-15 00:00:00