Abstract:
:We present the design of an electronically controlled drug delivery system. The intravaginally located device is a low-invasive platform that can measure and react inside the cow vagina while providing external control and monitoring ability. The electronics manufactured from off the shelf components occupies 16 mL of a Theratron syringe. A microcontroller reads and logs sensor data and controls a gascell. The generated gas pressure propels the syringe piston and releases the formulation. A two way radio link allows communication between other devices or a base station. Proof of principle experiments confirm variable-rate, arbitrary profile drug delivery qualified by internal sensors. A total volume of 30 mL was dispensed over a 7-day-period with a volume error of +/- 1 mL or +/- 7% for larger volumes. Delivery was controlled or overridden via the wireless link, and proximity to other devices was detected and recorded. The results suggest that temperature and activity sensing or social grouping determined via proximity can be used to detect oestrus and trigger appropriate responses.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Cross PS,Künnemeyer R,Bunt CR,Carnegie DA,Rathbone MJdoi
10.1016/j.ijpharm.2004.05.023keywords:
subject
Has Abstractpub_date
2004-09-10 00:00:00pages
35-44issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517304002911journal_volume
282pub_type
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