Abstract：
:To predict drug dissolution and understand the mechanisms of drug release from wax matrix dosage forms containing glyceryl monostearate (GM; a wax base), aminoalkyl methacrylate copolymer E (AMCE; a pH-dependent functional polymer), and acetaminophen (APAP; a model drug), we tried to derive a novel mathematical model with respect to erosion and diffusion theory. Our model exhibited good agreement with the whole set of experimentally obtained values pertaining to APAP release at pH 4.0 and pH 6.5. In addition, this model revealed that the eroding speed of wax matrices was strongly influenced by the loading content of AMCE, but not that of APAP, and that the diffusion coefficient increased as APAP loading decreased and AMCE loading increased, thus directly defining the physicochemical properties of erosion and diffusion. Therefore, this model might prove a useful equation for the precise prediction of dissolution and for understanding the mechanisms of drug release from wax matrix dosage forms.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Agata Y,Iwao Y,Shiino K,Miyagishima A,Itai Sdoi
10.1016/j.ijpharm.2011.05.015subject
Has Abstractpub_date
2011-07-29 00:00:00pages
63-8issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(11)00410-8journal_volume
414pub_type
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