Abstract:
:The study of controlled release and drug release devices has been dominated by considerations of the bulk or average properties of material or devices. Yet the outermost surface atoms play a central role in their performance. The objective of this article has been to characterize the surface of hydrophilic matrix tablets using the contact angle (CA) method to ascertain the surface free energy, and atomic force microscopy (AFM) and confocal microscopy (CM) for the physical characterization of the surface of the hydrophilic matrix. The surface free energy results obtained show that hydroxypropylmethylcellulose K15M hinders the spreading of water on the surface of the tablet, such that the concentration of HPMC K15M increases the reaction rate of the hydrophobic interactions between the chains of HPMC K15M which increases with respect to the rate of penetration of water into the tablet. In this study, we developed a new method to characterize the swelling of the tablets and established a relationship between the new method based on microswelling and the swelling ratio parameter. The surface texture parameters have been determined and the morphology of the tablets of the different formulations and the evolution of the surface morphology after interacting with the water, swelling and forming a gel layer were characterized. This work represents significant progress in the characterization of matrix tablets.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Saurí J,Suñé-Negre JM,Díaz-Marcos J,Vilana J,Millán D,Ticó JR,Miñarro M,Pérez-Lozano P,García-Montoya Edoi
10.1016/j.ijpharm.2014.11.054subject
Has Abstractpub_date
2015-01-15 00:00:00pages
328-340issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(14)00869-2journal_volume
478pub_type
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