Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes: Evaluation of suitable plasticizers.


:The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes. Specifically, the effect of mannitol (MAN), sorbitol (SOR), sucrose (SUC), anhydrous citric acid (CA), triethyl citrate (TEC) and low-molecular weight polyethylene glycol (PEG400) on PVA's melting properties, physical state and thermal degradation was evaluated via differential scanning calorimetry (DSC), powder X-ray diffractometry (pXRD) and thermo-gravimetric analysis (TGA). Results showed that the use of MAN, SOR, SUC and PEG400 led to the reduction of PVA's melting onset temperature, while MAN, SUC, CA and SOR were amorphously dispersed within PVA's matrix, and the addition of SUC and CA resulted in significant reduction of PVA's crystallinity. TGA results showed the formation of thermally highly unstable PVA mixtures in the cases of CA and TEC (degradation started from ~150 °C and ~125 °C, respectively), while significant molecular interactions were identified by FTIR in the cases of PVA-MAN, PVA-SOR and PVA-SUC. Hot-stage polarized microscopy (HSM) revealed PVA's melt miscibility only with MAN and SOR, while melt flow index (MFI) measurements showed that the use of MAN, SOR and PEG400 resulted in a significant improvement of PVA's melt flow properties. Finally, MD simulations were in close agreement with the experimental observations, indicating that they can be considered as a promising tool for the theoretical modelling of such systems.


Int J Pharm


Katopodis K,Kapourani A,Vardaka E,Karagianni A,Chorianopoulou C,Kontogiannopoulos KN,Bikiaris DN,Kachrimanis K,Barmpalexis P




Has Abstract


2020-03-30 00:00:00












  • Bioavailability of ibuprofen from matrix mini-tablets based on a mixture of starch and microcrystalline wax.

    abstract::The bioavailability of ibuprofen from matrix mini-tablets based on microcrystalline wax and a starch derivative was tested. An oral dose of 300 mg of ibuprofen was administered to healthy volunteers (n=8) in a randomized cross-over study design either as a commercial matrix formulation (Ibu-Slow 600) or as mini-tablet...

    journal_title:International journal of pharmaceutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: De Brabander C,Vervaet C,Görtz JP,Remon JP,Berlo JA

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  • Systematic evaluation of design features enables efficient selection of Π electron-stabilized polymeric micelles.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Sheybanifard M,Beztsinna N,Bagheri M,Buhl EM,Bresseleers J,Varela-Moreira A,Shi Y,van Nostrum CF,van der Pluijm G,Storm G,Hennink WE,Lammers T,Metselaar JM

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  • Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method.

    abstract::Sustained-release nitrendipine microspheres were prepared in liquid system by quasi-emulsion solvent diffusion method, in which the Aerosil was employed as an inert dispersing carrier to improve the dissolution rate of nitrendipine, and Eudragit RS as a retarding agent to control the release rate. The resultant micros...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Yang Ms,Cui Fd,You Bg,Fan Yl,Wang L,Yue P,Yang H

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  • Synthesis and characterization of biocompatible poly(organophosphazenes) aiming for local delivery of protein drugs.

    abstract::Biocompatible and thermosensitive poly(organophosphazenes) with a lower critical solution temperature (LCST) below body temperature have been designed with the aim for the local delivery of peptide and protein drugs. These polymers could be synthesized by introducing short chain tri- or tetraethylene glycol as a hydro...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Seong JY,Jun YJ,Kim BM,Park YM,Sohn YS

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  • Formation, characterization and pH dependence of rifampicin: heptakis(2,6-di-O-methyl)-β-cyclodextrin complexes.

    abstract::Rifampicin (Rif) is a broad spectrum antibiotic used as a first line agent in the treatment of mycobacterial infections. However, its low solubility and reduced stability in water limit its bioavailability, thus requiring the use of complex formulations. Here, we present a systematic study of Rif in complex with a met...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Angiolini L,Agnes M,Cohen B,Yannakopoulou K,Douhal A

    更新日期:2017-10-15 00:00:00

  • Insulin nanoparticle preparation and encapsulation into poly(lactic-co-glycolic acid) microspheres by using an anhydrous system.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Han Y,Tian H,He P,Chen X,Jing X

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  • MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Handler AM,Fallah M,Just Pedersen A,Pommergaard Pedersen G,Troensegaard Nielsen K,Janfelt C

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Li HY,Xu EY

    更新日期:2017-09-15 00:00:00

  • Risperidone solid dispersion for orally disintegrating tablet: its formulation design and non-destructive methods of evaluation.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Rahman Z,Zidan AS,Khan MA

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Zariwala MG,Elsaid N,Jackson TL,Corral López F,Farnaud S,Somavarapu S,Renshaw D

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Moesby L,Jensen S,Hansen EW,Christensen JD

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Fukui H,Koike T,Saheki A,Sonoke S,Tomii Y,Seki J

    更新日期:2003-09-16 00:00:00

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Jia L,Li Z,Shen J,Zheng D,Tian X,Guo H,Chang P

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Mitra B,Thool P,Meruva S,Aycinena JA,Li J,Patel J,Patel K,Agarwal A,Karki S,Bowen W

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Romøren K,Pedersen S,Smistad G,Evensen Ø,Thu BJ

    更新日期:2003-08-11 00:00:00

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nuijen B,Bouma M,Henrar RE,Brauns U,Bette P,Bult A,Beijnen JH

    更新日期:2000-01-25 00:00:00

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Agu R,MacDonald C,Cowley E,Shao D,Renton K,Clarke DB,Massoud E

    更新日期:2011-03-15 00:00:00

  • Effect of storage on microstructural changes of Carbopol polymers tracked by the combination of positron annihilation lifetime spectroscopy and FT-IR spectroscopy.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Szabó B,Süvegh K,Zelkó R

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nunes PS,Rabelo AS,Souza JC,Santana BV,da Silva TM,Serafini MR,Dos Passos Menezes P,Dos Santos Lima B,Cardoso JC,Alves JC,Frank LA,Guterres SS,Pohlmann AR,Pinheiro MS,de Albuquerque RL Júnior,Araújo AA

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    journal_title:International journal of pharmaceutics

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Grabovac V,Bernkop-Schnürch A

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Reis AV,Cavalcanti OA,Rubira AF,Muniz EC

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    journal_title:International journal of pharmaceutics

    pub_type: 评论,杂志文章


    authors: Le Brun PP,de Boer AH,Gjaltema D,Hagedoorn P,Heijerman HG,Frijlink HW

    更新日期:1999-11-05 00:00:00

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Kraus T,Winter G,Engert J

    更新日期:2019-03-25 00:00:00

  • Synbiotic loaded chitosan-Ca-alginate microparticles reduces inflammation in the TNBS model of rat colitis.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Ivanovska TP,Mladenovska K,Zhivikj Z,Pavlova MJ,Gjurovski I,Ristoski T,Petrushevska-Tozi L

    更新日期:2017-07-15 00:00:00

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Krauland AH,Alonso MJ

    更新日期:2007-08-01 00:00:00

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    abstract::Well known aging problems with rubbery starch films are the migration of plasticizer and increased crystallinity leading to embrittlement. The effects of a combination of sorbitol and glycerol used as plasticizers on mechanical, moisture permeability and solid-state properties of rubbery amylose maize starch (Hylon VI...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Krogars K,Heinämäki J,Karjalainen M,Niskanen A,Leskelä M,Yliruusi J

    更新日期:2003-01-30 00:00:00

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Michie H,Podczeck F,Newton JM

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Lagarce F,Garcion E,Faisant N,Thomas O,Kanaujia P,Menei P,Benoit JP

    更新日期:2006-05-18 00:00:00

  • Applications of NIR spectroscopy to monitoring and analyzing the solid state during industrial crystallization processes.

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Févotte G,Calas J,Puel F,Hoff C

    更新日期:2004-04-01 00:00:00