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Development of a nanoamorphous exosomal delivery system as an effective biological platform for improved encapsulation of hydrophobic drugs.

Abstract：

:Despite their great potential, the nano-sized extracellular vesicles are yet to become effective delivery systems for poorly water-soluble drugs. Here, we present a novel platform of exosomes as a drug delivery system by engineering of a poorly water-soluble drug into a poloxamer-based molecular nanostructured dispersion composed of a hydrophilic and a hydrophobic moiety for an enhanced anticancer efficacy. For the first time, aspirin was loaded into exosomes as an anticancer agent via a one-step fabrication combining the nano-matrix formation of the nanostructured dispersion and exosomes loading. Our approach could transform crystalline aspirin to a nanoamorphous form in the nano-matrix structured exosomes, leading to increased drug encapsulation efficiency for exosomes, improved dissolution and strongly enhanced cytotoxicity of aspirin to cancer cells. Interestingly, cytotoxicity of aspirin to both breast and colorectal cancer cells could be strongly enhanced by the nanoamorphous aspirin-loaded exosomes, and this cytotoxic effect was more pronounced to parental cells of the exosomes, reminiscent of homing effect. Hence, this study has pioneered a novel nanoplatform of nanoamorphous exosomal delivery system to transform an anti-inflammatory drug into a potent anti-cancer agent.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Tran PHL,Wang T,Yin W,Tran TTD,Barua HT,Zhang Y,Midge SB,Nguyen TNG,Lee BJ,Duan W

doi

10.1016/j.ijpharm.2019.06.028

subject

Has Abstract

pub_date

2019-07-20 00:00:00

pages

697-707

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(19)30471-5

journal_volume

566

pub_type

杂志文章

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