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Multifunctional TK-VLPs nanocarrier for tumor-targeted delivery.

Abstract：

:Virus-like particles (VLPs) have been exploited for various biomedical applications, such as the monitoring, prevention, diagnosis and therapy of disease. In this study, a novel multifunctional VLPs nanocarrier (TK-VLPs) was prepared and used for tumor-targeted delivery. The SPR and cell uptake results indicated that the TK peptide is a "bi-functional ligand" with high affinity for Caco-2, HRT-18 and HUVEC cells through the integrin α6β1 and integrin αvβ3 receptors. The results of the direct immunofluorescence, SDS-PAGE and western blot assays demonstrated that the TK-VLPs were successfully prepared using the baculovirus expression system. Confocal laser scanning microscopy and the flow cytometry analysis validated that the TK-VLPs could target to Caco-2, HRT-18 and HUVEC cells. An in vivo study further confirmed that the TK-VLPs could target and efficiently deliver fluorescein to tumor cells and the tumor vasculature in mice bearing subcutaneous tumors. TK-VLPs-DOX displayed a uniform, spherical shape and an average size of approximately 28nm. The results of the cell uptake and cytotoxicity assays indicated that TK-VLPs-DOX could enhance the selectivity for colorectal cancer cells. Together, our studies provide strong evidence that TK-VLPs could target colon tumor cells and tumor angiogenesis with enhanced permeability and retention effects, suggesting that the TK-VLPs are a multifunctional nanocarrier with potential applications in a colon tumor-targeted drug delivery system.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Ren Y,Mu Y,Jiang L,Yu H,Yang S,Zhang Y,Wang J,Zhang H,Sun H,Xiao C,Peng H,Zhou Y,Lu W

doi

10.1016/j.ijpharm.2016.02.037

subject

Has Abstract

pub_date

2016-04-11 00:00:00

pages

249-57

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(16)30130-2

journal_volume

502

pub_type

杂志文章

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