Propolis as potential cosmeceutical sunscreen agent for its combined photoprotective and antioxidant properties.

abstract：:The purpose of this study was to optimize in vitro experimental conditions for the measurement of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) permeation across human skin using a flow-through diffusion cell system. The drug permeation rates through intact and stripped (stratum corneum (SC) removed) skin were also com...

journal_title：International journal of pharmaceutics

authors： Challapalli PV,Stinchcomb AL

更新日期：2002-07-25 00:00:00

abstract：:The main objective of the study was to evaluate if the liquid crystalline cubic phase gel of glyceryl monooleate (GMO) protects insulin from agitation induced aggregation. The aggregation of Humulin(R), Regular Iletin I(R) and Regular Iletin II(R), in cubic phase GMO gels at 30 U/g of gel was compared with that in PBS...

journal_title：International journal of pharmaceutics

authors： Sadhale Y,Shah JC

更新日期：1999-11-25 00:00:00

abstract：:The pharmacokinetics of miconazole were studied after intravenous administration to six sheep (4 mg/kg) of three aqueous solutions: a marketed micellar solution containing polyoxyl-35 castor oil (Daktarin IV(R)) was compared with two solutions both containing 50 mM lactic acid and a cyclodextrin derivative (100 mM HP-...

journal_title：International journal of pharmaceutics

authors： Piel G,Evrard B,Van Hees T,Delattre L

更新日期：1999-03-25 00:00:00

abstract：:The focus of the current study was to explore whether immobilization of proteases to microparticles could result in their enhanced penetration into mucus. The proteases papain (PAP) and bromelain (BROM) were covalently attached to a polyacrylate (PAA; Carbopol 971P) via amide bond formation based on carbodiimide react...

journal_title：International journal of pharmaceutics

authors： Mahmood A,Laffleur F,Leonaviciute G,Bernkop-Schnürch A

更新日期：2017-10-30 00:00:00

abstract：:Breast cancer is a heterogeneous group of neoplasms predominantly originating in the terminal duct lobular units. It represents the leading cause of cancer death in women and the survival frequencies for patients at advanced stages of the disease remain low. New treatment options need to be researched to improve these...

journal_title：International journal of pharmaceutics

authors： Aznar MÁ,Lasa-Saracíbar B,Estella-Hermoso de Mendoza A,Blanco-Prieto MJ

更新日期：2013-10-01 00:00:00

abstract：:A Therapeutic Nipple Shield (TNS) was previously developed to respond to the global need for new infant therapeutic delivery technologies. However, the release efficiency for the same Active Pharmaceutical Ingredient (API) from different therapeutic matrices within the TNS formulation has not yet been investigated. To...

journal_title：International journal of pharmaceutics

authors： Maier T,Scheuerle RL,Markl D,Bruggraber S,Zeitler A,Fruk L,Slater NKH

更新日期：2018-02-15 00:00:00

abstract：:The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery system...

journal_title：International journal of pharmaceutics

authors： Wang D,Li W,Pechar M,Kopecková P,Brömme D,Kopecek J

更新日期：2004-06-11 00:00:00

abstract：:Amorphous nanoparticles are able to enhance the kinetic solubility and concomitant dissolution rates of BCS class II and BCS class II/IV molecules due to their characteristic increased supersaturation levels, smaller particle size and greater surface area. A DoE approach was applied to investigate formulation and spra...

journal_title：International journal of pharmaceutics

authors： Jog R,Kumar S,Shen J,Jugade N,Tan DC,Gokhale R,Burgess DJ

更新日期：2016-02-10 00:00:00

abstract：:Curcumin (CCM), a yellow natural polyphenol extracted from turmeric (Curcuma longa), has potent anti-cancer properties as has been demonstrated in various human cancer cells. However, the widespread clinical application of this efficient agent in cancer and other diseases has been limited by its poor aqueous solubilit...

journal_title：International journal of pharmaceutics

authors： Kim TH,Jiang HH,Youn YS,Park CW,Tak KK,Lee S,Kim H,Jon S,Chen X,Lee KC

更新日期：2011-01-17 00:00:00

abstract：:An increasing human population requires a secure food supply and a cost effective, oral vaccine delivery system for livestock would help facilitate this end. Recombinant antigen adsorbed onto silica beads and coated with myristic acid, was released (∼15% (w/v)) over 24 h at pH 8.8. At pH 2, the myristic acid acted as ...

journal_title：International journal of pharmaceutics

authors： Pettit MW,Dyer PD,Mitchell JC,Griffiths PC,Alexander B,Cattoz B,Heenan RK,King SM,Schweins R,Pullen F,Wicks SR,Richardson SC

更新日期：2014-07-01 00:00:00

abstract：:Lopinavir (LVR) is extensively metabolized by CYP3A4 and is prevented from entering the cells by membrane efflux pumps such as P-gp and MRP2. In an approach to evade the first-pass metabolism and efflux of LVR, peptide prodrugs of LVR [valine-valine-lopinavir (VVL) and glycine-valine-lopinavir (GVL)] were synthesized....

journal_title：International journal of pharmaceutics

authors： Agarwal S,Boddu SH,Jain R,Samanta S,Pal D,Mitra AK

更新日期：2008-07-09 00:00:00

abstract：:The compaction of powder beds into solid bodies occurs by virtue of the formation of inter-particle bonds. The mechanical strength of the compact depends on the type of bonding interaction, as well as, the inter-particle contact area created in the compression process. A hybrid quasi-continuum computational approach h...

journal_title：International journal of pharmaceutics

authors： Koynov A,Akseli I,Cuitiño AM

更新日期：2011-10-14 00:00:00

abstract：:A novel delivery system based on drug-cyclodextrin (CD) complexation and liposomes has been developed to improve therapeutic effect. Three different means, i.e., co-evaporation (COE), co-ground (GR) and co-lyophilization (COL) and three different CDs (β-CD, HP-β-CD and SBE-β-CD) were contrasted to investigate the char...

journal_title：International journal of pharmaceutics

authors： Zhang L,Zhang Q,Wang X,Zhang W,Lin C,Chen F,Yang X,Pan W

更新日期：2015-08-15 00:00:00

abstract：:Local drug delivery into oral cavity offers many advantages over systemic administration in treatment of the oral infections. In this study, monolayer and bilayered mucoadhesive film and wafer formulations were developed as local drug delivery platforms using chitosan and hydroxypropyl methylcellulose (HPMC). Cefuroxi...

journal_title：International journal of pharmaceutics

authors： Timur SS,Yüksel S,Akca G,Şenel S

更新日期：2019-03-25 00:00:00

abstract：:Liposomes, coated with transferrin (Tf)-coupled polyethylene glycol are considered to be potent carriers for drug delivery to various organs via receptor-mediated endocytosis. Since Tf receptors were ubiquitously expressed in various organs, additional perturbation of the liposomes such as regulation of the size may b...

journal_title：International journal of pharmaceutics

authors： Hatakeyama H,Akita H,Maruyama K,Suhara T,Harashima H

更新日期：2004-08-20 00:00:00

abstract：:The aim of these studies was to evaluate the binding, uptake and transcytosis of 60 nm porous nanoparticles (NPs) that differed in their surface charge and inner composition on the blood-brain barrier (BBB). They were prepared from maltodextrins derived with or without a cationic ligand. In the cationic NPs an anionic...

journal_title：International journal of pharmaceutics

authors： Jallouli Y,Paillard A,Chang J,Sevin E,Betbeder D

更新日期：2007-11-01 00:00:00

abstract：:The use of mesh in hernia repair has become common, because of lower recurrence rate and simple application. Data from the meta-analysis and the multi-central studies support the use of meshes in hernia repair. One of the complications due to the hernia repair with mesh is the infection. The incidence range is between...

journal_title：International journal of pharmaceutics

authors： Cakmak A,Cirpanli Y,Bilensoy E,Yorganci K,Caliş S,Saribaş Z,Kaynaroğlu V

更新日期：2009-11-03 00:00:00

abstract：:Oral drug delivery is the most preferred route for patients; however, the low solubility of drugs and the resultant poor absorption compromise the benefits of oral administration. On the other hand, for years, the overwhelmingly accepted mechanism for enhanced oral absorption using lipid nanocarriers was based on the ...

journal_title：International journal of pharmaceutics

authors： He W,Yang K,Fan L,Lv Y,Jin Z,Zhu S,Qin C,Wang Y,Yin L

更新日期：2015-11-10 00:00:00

abstract：:Pharmacopoeias prescribe tests to determine the levels of arsenic in raw materials and glass containers. In this study, glass ampoules for injectables containing individually the main components of intravenous nutrition formulations were submitted to the hydrolytic resistance test by heating at 121 degrees C for 30 mi...

journal_title：International journal of pharmaceutics

authors： Bohrer D,Becker E,Nascimento PC,Mörschbächer V,de Carvalho LM,da Silva Marques M

更新日期：2006-06-06 00:00:00

abstract：:We studied skin occlusion effects in vitro and in vivo on local and systemic delivery of ketoprofen across the organ, using the drug in a conventional non-occlusive topical gel (Togal Mobil-Gel), an occlusive tape (Mohrus), and the new targeted analgesic (Diractin), comprising ultradeformable, hydrophilic carriers in ...

journal_title：International journal of pharmaceutics

authors： Cevc G,Mazgareanu S,Rother M,Vierl U

更新日期：2008-07-09 00:00:00

abstract：:Since the discovery of amylin its use has been discouraged by the inadequacy of the protocol involving multiple injections in addition to insulin. We aimed here to develop a combined fixed-dose formulation of pramlintide with fast-acting insulin. We have investigated the compatibility of regular and fast-acting insuli...

journal_title：International journal of pharmaceutics

authors： da Silva DC,Lima LMTR

更新日期：2018-08-25 00:00:00

abstract：:Sustained release of active interferon-α (IFN-α) has been achieved from core-shell nanoparticles (NPs) prepared by aqueous precipitation of IFN-α-enriched human serum albumin (HSA-IFN-α) and layer-by-layer (L-b-L) by coating of the IFN-α NPs with poly(sodium-4-styrene) sulphonate (PSS) and chitosan (Chit). The concent...

journal_title：International journal of pharmaceutics

authors： Kristó K,Szekeres M,Makai Z,Márki Á,Kelemen A,Bali L,Pallai Z,Dékány I,Csóka I

更新日期：2020-01-05 00:00:00

abstract：:Over the last 10 years, the development of intelligent biomaterials for medical and pharmaceutical applications has attracted growing interest by combining interdisciplinary efforts. Between them nanogels represent one of the most attractive carriers for innovative drug delivery systems. In the present investigation n...

journal_title：International journal of pharmaceutics

authors： Nita LE,Chiriac AP,Diaconu A,Tudorachi N,Mititelu-Tartau L

更新日期：2016-12-30 00:00:00

abstract：:A polymeric prodrug of cisplatin (CP) with simple chemical structure was synthesized based on pullulan and its therapeutic effects on human hepatocellular carcinoma (HCC) were studied in vitro and in vivo. Briefly, CP was linked to pullulan monosuccinate (SUPA) via coordination bond to form prodrug of CP-SUPA with the...

journal_title：International journal of pharmaceutics

authors： Wang Y,Liu Y,Liu Y,Zhou W,Wang H,Wan G,Sun D,Zhang N,Wang Y

更新日期：2015-04-10 00:00:00

abstract：:The present study investigated the ability of a polyelectrolyte complex (CS/CMCS-NPs), composed of chitosan (CS) and o-carboxymeymethy chitosan (CMCS) as a pH responsive carrier for oral delivery of doxorubicin hydrochloride (DOX). The obtained CS/CMCS-NPs were characterized for various parameters including morphology...

journal_title：International journal of pharmaceutics

authors： Feng C,Wang Z,Jiang C,Kong M,Zhou X,Li Y,Cheng X,Chen X

更新日期：2013-11-30 00:00:00

abstract：:The PEGylated liposomal (PEG-LP) Doxorubicin, PEG-LP (DOX), with a diameter of around 100nm, accumulates in tumors via the enhanced permeability and retention (EPR) effect, and is used clinically for the treatment of several types of cancer. However, there are a number of tumor types that are resistant to DOX. We repo...

journal_title：International journal of pharmaceutics

authors： Kibria G,Hatakeyama H,Sato Y,Harashima H

更新日期：2016-07-25 00:00:00

abstract：:The combination therapy of gestodene (GEST) and ethinylestradiol (EE) has shown advanced contraception effect and lower side effect. The present study was designed to develop a weekly sustained release matrix type transdermal patch containing GEST and EE using blends of different polymeric combinations. The multiple-l...

journal_title：International journal of pharmaceutics

authors： Gao Y,Liang J,Liu J,Xiao Y

更新日期：2009-07-30 00:00:00

abstract：:Nanoparticles delivery of oligonucleotides represents a potential approach for cancer treatment. However, most of the experiments were based on established cancer cell lines and may not reflect the original solid tumor in vivo. Both, tumor microenvironment and tumor cell biological properties in the tumor can influenc...

journal_title：International journal of pharmaceutics

authors： Dong M,Philippi C,Loretz B,Nafee N,Schaefer UF,Friedel G,Ammon-Treiber S,Griese EU,Lehr CM,Klotz U,Mürdter TE

更新日期：2011-10-31 00:00:00

abstract：:The present study reports the production and characterization of PEG-coated silica nanoparticles (SiNP-PEG) containing insulin for oral administration. High (PEG 20,000) and low (PEG 6000) PEG molecular weights were used in the preparations. SiNP were produced by sol-gel technology followed by PEG adsorption and chara...

journal_title：International journal of pharmaceutics

authors： Andreani T,de Souza AL,Kiill CP,Lorenzón EN,Fangueiro JF,Calpena AC,Chaud MV,Garcia ML,Gremião MP,Silva AM,Souto EB

更新日期：2014-10-01 00:00:00

abstract：:Polysaccharides-based delivery systems and interpolyelectrolyte complexes (IPECs) are interesting alternatives to control the release of drugs, thereby improving therapies. Benznidazole (BZ) is the selected drug for Chagas disease pharmacotherapy. However, its side effects limit its efficacy and safety. We developed n...

journal_title：International journal of pharmaceutics

authors： García MC,Manzo RH,Jimenez-Kairuz A

更新日期：2018-07-10 00:00:00