Propolis as potential cosmeceutical sunscreen agent for its combined photoprotective and antioxidant properties.


:Propolis, bee glue, and its main polyphenolic components show high antioxidant activity as found measuring their inhibitory action on lipid peroxidation of linoleic acid (LA) in sodium dodecyl sulfate (SDS) micelles. Furthermore, these substances evidence effectiveness as broad spectrum UVB and UVA photoprotection sunscreens, as it results by measurements of sun protection factor (SPF), the universal indicator related primarily to UVB radiations, and of the two parameters giving an indication of the UVA absorbance properties, i.e. UVA/UVB ratio and critical wavelength. The combination of these characteristics moves up propolis and its main polyphenolic components to the class of cosmeceuticals, as possible active ingredient of sunscreen commercial formulations for their protective and preventive properties.


Int J Pharm


Gregoris E,Fabris S,Bertelle M,Grassato L,Stevanato R




Has Abstract


2011-02-28 00:00:00














  • Emerging trends in the stabilization of amorphous drugs.

    abstract::The number of active pharmaceutical substances having high therapeutic potential but low water solubility is constantly increasing, making it difficult to formulate these compounds as oral dosage forms. The solubility and dissolution rate, and thus potentially the bioavailability, of these poorly water-soluble drugs c...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Laitinen R,Löbmann K,Strachan CJ,Grohganz H,Rades T

    更新日期:2013-08-30 00:00:00

  • Tensile and shear methods for measuring strength of bilayer tablets.

    abstract::Both shear and tensile measurement methods have been used to quantify interfacial bonding strength of bilayer tablets. The shear method is more convenient to perform, but reproducible strength data requires careful control of the placement of tablet and contact point for shear force application. Moreover, data obtaine...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Chang SY,Li JX,Sun CC

    更新日期:2017-05-15 00:00:00

  • Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: in vitro and in vivo evaluation.

    abstract::The present study investigated the ability of a polyelectrolyte complex (CS/CMCS-NPs), composed of chitosan (CS) and o-carboxymeymethy chitosan (CMCS) as a pH responsive carrier for oral delivery of doxorubicin hydrochloride (DOX). The obtained CS/CMCS-NPs were characterized for various parameters including morphology...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Feng C,Wang Z,Jiang C,Kong M,Zhou X,Li Y,Cheng X,Chen X

    更新日期:2013-11-30 00:00:00

  • Hydrogel blends with adjustable properties as patches for transdermal delivery.

    abstract::The effect of different preparation parameters were analyzed with respect to the rheological and pharmaceutical characteristics of hydrogel blend patches, as transdermal delivery formulation. Mixtures of pectin and gelatin were employed for the production of patches, with adjustable properties, following a two-step ge...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Mazzitelli S,Pagano C,Giusepponi D,Nastruzzi C,Perioli L

    更新日期:2013-09-15 00:00:00

  • Formulation characteristics and in vitro release testing of cyclosporine ophthalmic ointments.

    abstract::The aim of the present study was to investigate the relationship between formulation/process variables versus the critical quality attributes (CQAs) of cyclosporine ophthalmic ointments and to explore the feasibility of using an in vitro approach to assess product sameness. A definitive screening design (DSD) was used...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Dong Y,Qu H,Pavurala N,Wang J,Sekar V,Martinez MN,Fahmy R,Ashraf M,Cruz CN,Xu X

    更新日期:2018-06-10 00:00:00

  • Novel fenofibric acid-loaded controlled release pellet bioequivalent to choline fenofibrate-loaded commercial product in beagle dogs.

    abstract::The objective of this study was to develop a novel fenofibric acid-loaded controlled release pellet showing enhanced, or equivalent to, bioavailability compared with two commercially available products containing fenofibrate or choline fenofibrate. The effect of solubilizing agents on drug solubility and the impact of...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kim KS,Jin SG,Mustapha O,Yousaf AM,Kim DW,Kim YH,Kim JO,Yong CS,Woo JS,Choi HG

    更新日期:2015-07-25 00:00:00

  • Investigating permeability related hurdles in oral delivery of 11-keto-β-boswellic acid.

    abstract::11-Keto-β-boswellic acid (KBA) is an important and potent boswellic acids responsible for anti-inflammatory action of Boswellia extract. However, its pharmaceutical development has been severely limited by its poor oral bioavailability. The present work aims to investigate the permeability related hurdles in oral deli...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Bagul P,Khomane KS,Bansal AK

    更新日期:2014-04-10 00:00:00

  • Rapid microneedle fabrication by heating and photolithography.

    abstract::Many fabrication methods for microneedle (MN) involve harsh conditions and long drying time. This study aims to fabricate a dissolving MN patch in a simple and efficient manner under mild conditions, using a combination of thermal and photo polymerisation. The MN patch was fabricated by pre-polymerisation of vinylpyrr...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kathuria H,Kang K,Cai J,Kang L

    更新日期:2020-02-15 00:00:00

  • Rationally designed hyaluronic acid-based nano-complexes for pentamidine delivery.

    abstract::Nanoparticles of polymeric complexes made of hyaluronic acid and polyarginine were investigated for the encapsulation of the cationic hydrophilic drug pentamidine isethionate. The interaction between the anionic hyaluronic acid and the cationic pentamidine resulting in the formation of polyelectrolyte complexes was fi...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Carton F,Chevalier Y,Nicoletti L,Tarnowska M,Stella B,Arpicco S,Malatesta M,Jordheim LP,Briançon S,Lollo G

    更新日期:2019-09-10 00:00:00

  • Prolonged analgesic effect of PLGA-encapsulated bee venom on formalin-induced pain in rats.

    abstract::To enhance the medicinal activity of bee venom (BV) acupuncture, bee venom was loaded into biodegradable poly(D,L-lactide-co-glycolide) nanoparticles (BV-PLGA-NPs) by a water-in-oil-in-water-emulsion/solvent-evaporation technique. Rat formalin tests were performed after subcutaneous injection of BV-PLGA-NPs to the Zus...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Jeong I,Kim BS,Lee H,Lee KM,Shim I,Kang SK,Yin CS,Hahm DH

    更新日期:2009-10-01 00:00:00

  • Synthesis of a bi-functional dendrimer-based nanovehicle co-modified with RGDyC and TAT peptides for neovascular targeting and penetration.

    abstract::The dual-ligand dendritic polyamidoamine-(polyethylene glycol)n-cyclic RGDyC peptide-(TAT peptide) (PPnR(T)) with various supplied molar ratios of polyethylene glycol (PEG) to polyamidoamine (PAMAM) (n=5, 15, 30) were designed as drug-carriers for the treatment of neovascular diseases; their targeting and penetrating ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Li J,Zhang X,Wang M,Li X,Mu H,Wang A,Liu W,Li Y,Wu Z,Sun K

    更新日期:2016-03-30 00:00:00

  • Functionalized single-walled carbon nanotubes: cellular uptake, biodistribution and applications in drug delivery.

    abstract::The unique properties of single-walled carbon nanotubes (SWNTs) enable them to play important roles in many fields. One of their functional roles is to transport cargo into cell. SWNTs are able to traverse amphipathic cell membranes due to their large surface area, flexible interactions with cargo, customizable dimens...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Li Z,de Barros ALB,Soares DCF,Moss SN,Alisaraie L

    更新日期:2017-05-30 00:00:00

  • Positively charged microemulsions for topical application.

    abstract::The study reports pig-skin permeation and skin accumulation of miconazole nitrate (MCZ) from positively charged microemulsions containing water, 1-decanol/1-dodecanol (2:1, w/w), lecithin and/or decyl polyglucoside at different weight ratios, propylene glycol, 1,2 hexanediol and a cationic charge-inducing agent (stear...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Peira E,Carlotti ME,Trotta C,Cavalli R,Trotta M

    更新日期:2008-01-04 00:00:00

  • In vitro and in vivo degradation behavior and the long-term performance of biodegradable PLCL balloon implants.

    abstract::Biodegradable poly(l-lactide-co-ε-caprolactone) (PLCL) are used to prepare inflatable balloon implants in treating rotator-cuff injuries and tissue separation. These balloon implants act as a temporary spacer for tissues, while reducing pain and allowing rehabilitation after surgery. It is essential to ensure that eac...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Haim Zada M,Kumar A,Elmalak O,Markovitz E,Icekson R,Domb AJ

    更新日期:2020-01-25 00:00:00

  • The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers.

    abstract::Previous in vivo studies using PEG 400 showed an enhancement in the bioavailability of ranitidine. This study investigated the effect of PEG 200, 300 and 400 on ranitidine transport across Caco-2 cells. The effect of PEG polymers (20%, v/v) on the bi-directional flux of (3)H-ranitidine across Caco-2 cell monolayers wa...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Ashiru-Oredope DA,Patel N,Forbes B,Patel R,Basit AW

    更新日期:2011-05-16 00:00:00

  • Thermosensitive glycol chitosan-based hydrogel as a topical ocular drug delivery system for enhanced ocular bioavailability.

    abstract::In the present study, we developed and evaluated an in situ gelling system based on hexanoyl glycol chitosan (H-GCS) for enhanced ocular bioavailability. An aqueous solution of H-GCS exhibited a typical sol-gel transition at 32 °C. The formed H-GCS hydrogel was characterized by rheology and scanning electron microscop...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Shi H,Wang Y,Bao Z,Lin D,Liu H,Yu A,Lei L,Li X,Xu X

    更新日期:2019-10-30 00:00:00

  • Efficient incorporation and protection of lansoprazole in cyclodextrin metal-organic frameworks.

    abstract::Lansoprazole (LPZ) is an acid pump inhibitor, which readily degrades upon acidic or basic conditions and under heating. We investigated here LPZ stability upon incorporation in particles made of cyclodextrin metal-organic frameworks (CD-MOFs). LPZ loaded CD-MOFs were successfully synthesized, reaching high LPZ payload...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Li X,Porcino M,Martineau-Corcos C,Guo T,Xiong T,Zhu W,Patriarche G,Péchoux C,Perronne B,Hassan A,Kümmerle R,Michelet A,Zehnacker-Rentien A,Zhang J,Gref R

    更新日期:2020-07-30 00:00:00

  • Effects of polyamidoamine (PAMAM) dendrimers on the nasal absorption of poorly absorbable drugs in rats.

    abstract::The absorption enhancing effects of polyamidoamine (PAMAM) dendrimers with various concentrations and generations on the nasal absorption of fluorescein isothiocyanate-labeled dextran with an average molecular weight of 4400 (FD4) were initially studied in rats. PAMAM dendrimers with different generations improved the...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Dong Z,Katsumi H,Sakane T,Yamamoto A

    更新日期:2010-06-30 00:00:00

  • Dispersibility of lactose fines as compared to API in dry powders for inhalation.

    abstract::This work investigates the dispersion performance of fine lactose particles as function of processing time, and compares it to the API, using Beclomethasone Dipropionate (BDP) as model API. The total load of fine particles is kept constant in the formulations while the proportions of API and lactose fines are varied. ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Thalberg K,Åslund S,Skogevall M,Andersson P

    更新日期:2016-05-17 00:00:00

  • Permeation of cyproterone acetate through pig skin from different vehicles with phospholipids.

    abstract::The permeation of cyproterone acetate (CPA) from Derma Membrane Structure (DMS) creams and liposomal formulations was investigated. Standard diffusion experiments with dermatomed porcine skin were performed. The cumulative CPA amount permeated of the DMS creams was between 2.9 and 6.8 microg/cm(2) within 48 h. By addi...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Valenta C,Janisch M

    更新日期:2003-06-04 00:00:00

  • Selection of high efficient transdermal lipid vesicle for curcumin skin delivery.

    abstract::Curcumin shows effective anti-inflammatory activities but is seldom used in clinic because of its poor solubility in water and vulnerablity to sunshine ultraviolet effect. Novel lipid vesicles have been developed as carriers for skin delivery. In this paper, lipid vesicles-propylene glycol liposomes (PGL), Ethosomes a...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Zhao YZ,Lu CT,Zhang Y,Xiao J,Zhao YP,Tian JL,Xu YY,Feng ZG,Xu CY

    更新日期:2013-09-15 00:00:00

  • Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model.

    abstract::In this study, topical minoxidil solutions supplemented with TPGS in cosolvent systems of various compositions consisting of water, alcohol, and polyethylene glycol 400 were designed to evaluate the efficacy of promoting hair growth after topical application and the safety in terms of the amount of minoxidil absorbed ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Chen CH,Sheu MT,Wu AB,Lin KP,Ho HO

    更新日期:2005-12-08 00:00:00

  • Effects of molecular weight of polyvinylpyrrolidone on the glass transition and crystallization of co-lyophilized sucrose.

    abstract::The purpose of the present study was to investigate the effects of molecular weight (MW) of polyvinylpyrrolidone (PVP) on glass transition and crystallization of sucrose. Thus, sucrose was co-lyophilized with 2.5 and 5.0% w/w PVP of different molecular weights, which were characterized using gel permeation chromatogra...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Zeng XM,Martin GP,Marriott C

    更新日期:2001-05-07 00:00:00

  • Bovine serum albumin-meloxicam nanoaggregates laden contact lenses for ophthalmic drug delivery in treatment of postcataract endophthalmitis.

    abstract::Postcataract endophthalmitis treatment through eye drops is of low corneal bioavailability and short residence time. The dominant NSAIDs therapy also suffers from severe ocular irritancy and low patients compliance. This study dispersed bovine serum albumin (BSA) coated meloxicam (MX) nanocrystals encapsulating nanoag...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Zhang W,Zu D,Chen J,Peng J,Liu Y,Zhang H,Li S,Pan W

    更新日期:2014-11-20 00:00:00

  • Cold flow of estradiol transdermal systems: influence of drug loss on the in vitro flux and drug transfer across human epidermis.

    abstract::The objective was to quantify drug loss due to cold flow (CF) in marketed estradiol transdermal drug delivery systems (TDDS), and study its influence on the in vitro flux and drug transfer across contacting skin. TDDS samples (products-A and B) were induced with CF at 25 and 32°C/60% RH by applying 1-kg force for 72h....

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Krishnaiah YS,Yang Y,Hunt RL,Khan MA

    更新日期:2014-12-30 00:00:00

  • In vitro and in vivo studies on ocular vitamin A palmitate cationic liposomal in situ gels.

    abstract::N-trimethyl chitosan (TMC) with different degree of quaternization (DQ) as the coating materials, vitamin A palmitate (VAP)-loaded cationic liposomes dispersed in thermo-sensitive in situ gels (ISG) with poloxamer 407 (P407) as the base were prepared in this study. VAP-loaded liposomes (VAPL) were prepared using a fil...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: He W,Guo X,Feng M,Mao N

    更新日期:2013-12-31 00:00:00

  • Microencapsulation of amorphous solid dispersions of fenretinide enhances drug solubility and release from PLGA in vitro and in vivo.

    abstract::The purpose of this study was to develop solid dispersions of fenretinide(4HPR), incorporate them into poly(lactic-co-glycolic)(PLGA) millicylindrical implants, and evaluate the resulting implants in vitro and in vivo for future applications in oral cancer chemoprevention. Due to the extreme hydrophobicity of 4HPR, 4H...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nieto K,Mallery SR,Schwendeman SP

    更新日期:2020-08-30 00:00:00

  • Assessment of disorder in crystalline powders--a review of analytical techniques and their application.

    abstract::The need to be able to measure amorphous contents in crystalline powders is now recognised. In this review, calorimetric and gravimetric methods are reviewed in a way that should alert workers in the field to the theoretical, and practical considerations which are important to understanding how best to study crystalli...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Buckton G,Darcy P

    更新日期:1999-03-15 00:00:00

  • Stabilization of gene delivery systems by freeze-drying.

    abstract::Freeze-drying of three different forms of gene delivery systems was performed using a controlled two-step drying process and 10% sucrose as lyoprotectant. Complexes of pCMVL plasmid with transferrin-conjugated polyethylenimine, adenovirus-enhanced transferrinfection consisting of pCMVL/transferrin-polylysine complexes...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Talsma H,Cherng J,Lehrmann H,Kursa M,Ogris M,Hennink WE,Cotten M,Wagner E

    更新日期:1997-11-28 00:00:00

  • Characterization and monitoring of pseudo-polymorphs in manufacturing process by NIR.

    abstract::Moisture-sensitive pseudo-polymorphs with different stabilities were characterized, and their polymorphisms were monitored in the process of tableting and film coating by near-infrared (NIR) spectroscopy. In this study, we proved that we could successfully maintain the crystal form ratio in the tablet by controlling t...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kamada K,Yoshimura S,Murata M,Murata H,Nagai H,Ushio H,Terada K

    更新日期:2009-02-23 00:00:00