Propolis as potential cosmeceutical sunscreen agent for its combined photoprotective and antioxidant properties.


:Propolis, bee glue, and its main polyphenolic components show high antioxidant activity as found measuring their inhibitory action on lipid peroxidation of linoleic acid (LA) in sodium dodecyl sulfate (SDS) micelles. Furthermore, these substances evidence effectiveness as broad spectrum UVB and UVA photoprotection sunscreens, as it results by measurements of sun protection factor (SPF), the universal indicator related primarily to UVB radiations, and of the two parameters giving an indication of the UVA absorbance properties, i.e. UVA/UVB ratio and critical wavelength. The combination of these characteristics moves up propolis and its main polyphenolic components to the class of cosmeceuticals, as possible active ingredient of sunscreen commercial formulations for their protective and preventive properties.


Int J Pharm


Gregoris E,Fabris S,Bertelle M,Grassato L,Stevanato R




Has Abstract


2011-02-28 00:00:00














  • A study on polymorphic forms of rifampicin for inhaled high dose delivery in tuberculosis treatment.

    abstract::Rifampicin is a first-line, highly effective drug currently used orally as a part of a lengthy multi-drug regimen against tuberculosis (TB). Despite the potential of inhaled therapy as an effective approach for TB treatment, an inhalable formulation of rifampicin has not yet been developed for clinical use. In order t...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Khadka P,Hill PC,Zhang B,Katare R,Dummer J,Das SC

    更新日期:2020-09-25 00:00:00

  • Influence of acylation on the adsorption of GLP-2 to hydrophobic surfaces.

    abstract::Acylation of proteins with a fatty acid chain has proven useful for prolonging the plasma half-lives of proteins. In formulation of acylated protein drugs, knowledge about the effect of acylation with fatty acids on the adsorption behaviour of proteins at interfaces will be valuable. The aim of this work was to study ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Pinholt C,Kapp SJ,Bukrinsky JT,Hostrup S,Frokjaer S,Norde W,Jorgensen L

    更新日期:2013-01-02 00:00:00

  • Determination of tacrolimus crystalline fraction in the commercial immediate release amorphous solid dispersion products by a standardized X-ray powder diffraction method with chemometrics.

    abstract::Clinical performance of an amorphous solid dispersion (ASD) drug product is related to the amorphous drug content because of the greater bioavailability of this form of the drug than its crystalline form. Therefore, it is paramount to monitor the amorphous and the crystalline fractions in the ASD products. The objecti...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Rahman Z,Siddiqui A,Bykadi S,Khan MA

    更新日期:2014-11-20 00:00:00

  • Simultaneous determination of amiloride and furosemide in pharmaceutical formulations by first digital derivative spectrophotometry.

    abstract::This work presents a simple and fast method for the simultaneous determination of amiloride and furosemide by digital derivative spectrophotometry. HCl 1 x 10(-2) mol/l dissolved in ethanol was used as solvent and to extract drugs from formulations. Subsequently the samples were evaluated directly by first digital der...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Inés Toral M,Pope S,Quintanilla S,Richter P

    更新日期:2002-12-05 00:00:00

  • Effect of alkylcarbonates of gamma-cyclodextrins with different chain lengths on drug complexation and release characteristics.

    abstract::Alkylcarbonates of gamma-cyclodextrins were produced and their inclusion complexes with four poorly water-soluble drugs of different structures and solubilities were prepared. The alkylcarbonates and the alkylcarbonate drug complexes were characterized by DSC and XRPD; the physical mixtures were used as control. Solub...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Cavalli R,Trotta F,Trotta M,Pastero L,Aquilano D

    更新日期:2007-07-18 00:00:00

  • Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis.

    abstract::The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis. Physicochemical characterization of blend MS was assessed using scanning electron microscopy (SEM), Fourier tr...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Duan H,Lü S,Qin H,Gao C,Bai X,Wei Y,Wu X,Liu M,Zhang X,Liu Z

    更新日期:2017-01-10 00:00:00

  • Investigation into the sorption of nitroglycerin and diazepam into PVC tubes and alternative tube materials during application.

    abstract::Plastic bags and tubes are increasingly used for the storage and application of pharmaceutical formulations. The most common polymer material for drug application sets is plasticized poly(vinylchloride) (PVC). During application of pharmaceutical drug solution through PVC tubes, the polymer and the contact media inter...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Treleano A,Wolz G,Brandsch R,Welle F

    更新日期:2009-03-18 00:00:00

  • Effects of gefitinib treatment on cellular uptake of extracellular vesicles in EGFR-mutant non-small cell lung cancer cells.

    abstract::Extracellular vesicles (exosomes, EVs) are cell membrane particles (30-200 nm) secreted by virtually all cells. During intercellular communication in the body, secreted EVs play crucial roles by carrying functional biomolecules (e.g., microRNAs and enzymes) into other cells to affect cellular function, including disea...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Takenaka T,Nakai S,Katayama M,Hirano M,Ueno N,Noguchi K,Takatani-Nakase T,Fujii I,Kobayashi SS,Nakase I

    更新日期:2019-12-15 00:00:00

  • Design of smart GE11-PLGA/PEG-PLGA blend nanoparticulate platforms for parenteral administration of hydrophilic macromolecular drugs: synthesis, preparation and in vitro/ex vivo characterization.

    abstract::Active drug targeting and controlled release of hydrophilic macromolecular drugs represent crucial points in designing efficient polymeric drug delivery nanoplatforms. In the present work EGFR-targeted polylactide-co-glycolide (PLGA) nanoparticles were made by a blend of two different PLGA-based polymers. The first, G...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Colzani B,Speranza G,Dorati R,Conti B,Modena T,Bruni G,Zagato E,Vermeulen L,Dakwar GR,Braeckmans K,Genta I

    更新日期:2016-09-25 00:00:00

  • Enhanced antioxidation via encapsulation of isooctyl p-methoxycinnamate with sodium deoxycholate-mediated liposome endocytosis.

    abstract::Isooctyl p-methoxycinnamate(OMC) is a commonly used chemical ultraviolet B sunscreen that suffers rapid degradation with current delivery systems following sun exposure. In this study, deoxycholate-mediated liposome (DOC-LS) endocytosis was employed to improve the antioxidation effects of OMC following topical adminis...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Zhang Y,Shen L,Zhang K,Guo T,Zhao J,Li N,Feng N

    更新日期:2015-12-30 00:00:00

  • Investigation of surfactants suitable for stabilizing of latanoprost.

    abstract::The content of latanoprost, a therapeutic drug for glaucoma, is likely to decrease in solution. In a previous study, we confirmed that this was associated with latanoprost adsorption to the container and hydrolysis of latanoprost, and established a formulation of latanoprost eye drop solution that can be stored at roo...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Ochiai A,Ohkuma M,Danjo K

    更新日期:2012-10-15 00:00:00

  • 3D printed capsules for quantitative regional absorption studies in the GI tract.

    abstract::Drug development is a long process which requires careful evaluation of the drug substance (active pharmaceutical ingredient, API), drug product (tablet, capsule etc.) and the bioperformance (both pre-clinical and clinical) before testing the efficacy of the final dosage form. The earliest assessment of a new drug sub...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Smith D,Kapoor Y,Hermans A,Nofsinger R,Kesisoglou F,Gustafson TP,Procopio A

    更新日期:2018-10-25 00:00:00

  • Powder, capsule and device: An imperative ménage à trois for respirable dry powders.

    abstract:OBJECTIVES:The development of inhaled products to treat or to prevent lung infection is a very active research field in drug delivery. The pulmonary route is extremely attractive but very challenging. This paper reports the study of excipient, capsule brand and device influence on the aerodynamic behavior of dry powder...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Schoubben A,Blasi P,Giontella A,Giovagnoli S,Ricci M

    更新日期:2015-10-15 00:00:00

  • Evaluation of manufacturing process parameters causing multilayer tablets delamination.

    abstract::The aim of this study was to evaluate the influence of tableting process parameters, i.e. turret rotation speed, pre-compaction and main compaction pressures, and their interactions on layer adhesion of bilayer tablets. The elastic recovery after compaction was used as estimation for the elasticity of the material. Th...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Bellini M,Walther M,Bodmeier R

    更新日期:2019-10-30 00:00:00

  • Nose-to-brain delivery of disulfiram nanoemulsion in situ gel formulation for glioblastoma targeting therapy.

    abstract::Glioblastoma (GBM) is a difficult-to-treat cancer, likely attributed to the blood brain barrier and drug resistance. Nose-to-brain drug delivery is a direct and non-invasive pathway for brain targeting with low systemic toxicity. Disulfiram (DSF) has shown its effectiveness against GBM, especially with copper ion (Cu)...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Qu Y,Li A,Ma L,Iqbal S,Sun X,Ma W,Li C,Zheng D,Xu Z,Zhao Z,Ma D

    更新日期:2021-01-21 00:00:00

  • Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design.

    abstract::The present study focused on the development and optimization of glycerosomes for dermal delivery of fisetin. The fisetin loaded glycerosomes formulation was optimized by Box-Behnken design. The independent variables were the lipoid S 100, glycerol, and sonication time, whereas the dependent variables were the vesicle...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Moolakkadath T,Aqil M,Ahad A,Imam SS,Praveen A,Sultana Y,Mujeeb M

    更新日期:2020-03-30 00:00:00

  • Physicochemical studies on Ciclopirox olamine complexes with divalent metal ions.

    abstract::Ciclopirox olamine (CPO) metal complexes have been prepared and characterized using elemental analysis, infra red (IR), melting point and differential scanning calorimetry (DSC). Spectroscopic titration using molar ratio method indicated the occurrence of 1:1 complexes for CPO with almost all the examined metals. Phys...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Tarawneh RT,Hamdan II,Bani-Jaber A,Darwish RM

    更新日期:2005-01-31 00:00:00

  • Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN).

    abstract::Solid lipid nanoparticles (SLN) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinit...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Souto EB,Anselmi C,Centini M,Müller RH

    更新日期:2005-05-13 00:00:00

  • Permeation of cyproterone acetate through pig skin from different vehicles with phospholipids.

    abstract::The permeation of cyproterone acetate (CPA) from Derma Membrane Structure (DMS) creams and liposomal formulations was investigated. Standard diffusion experiments with dermatomed porcine skin were performed. The cumulative CPA amount permeated of the DMS creams was between 2.9 and 6.8 microg/cm(2) within 48 h. By addi...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Valenta C,Janisch M

    更新日期:2003-06-04 00:00:00

  • Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example.

    abstract::The aim of this study was to develop a sensitive and discriminative in vitro-in silico model able to simulate the in vivo performance of three fenofibrate immediate release formulations containing different surfactants. In addition, the study was designed to investigate the effect of dissolution volume when predicting...

    journal_title:International journal of pharmaceutics

    pub_type: 临床试验,杂志文章


    authors: Berthelsen R,Sjögren E,Jacobsen J,Kristensen J,Holm R,Abrahamsson B,Müllertz A

    更新日期:2014-10-01 00:00:00

  • Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy.

    abstract::There is evidence that swallowing issues and dysphagia are an increasing problem of the aging population in the coming decades that is affecting oral medication administration. There is a variety of clinical expressions of swallowing dysfunction caused by aging, acute or chronic disease conditions, decline in physiolo...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Stegemann S,Gosch M,Breitkreutz J

    更新日期:2012-07-01 00:00:00

  • Nanoliposome-mediated targeting of antibodies to tumors: IVIG antibodies as a model.

    abstract::Monoclonal antibodies are routinely used as tools in immunotherapies against solid tumors. However, administration of monoclonal antibodies may cause undesired side effects due to their accumulation in non-targeted organs. Nanoliposomes of less than 200 nm can target antibodies to tumors by enhanced permeation and ret...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Nikpoor AR,Tavakkol-Afshari J,Gholizadeh Z,Sadri K,Babaei MH,Chamani J,Badiee A,Jalali SA,Jaafari MR

    更新日期:2015-11-10 00:00:00

  • Enhancement in bioavailability of ketorolac tromethamine via intranasal in situ hydrogel based on poloxamer 407 and carrageenan.

    abstract::The objective of this study was to construct a new in situ gel system based on the combination of poloxamer 407 and carrageenan (carrageenan-poloxamer 407 hydrogel, CPH) for intranasal delivery of ketorolac tromethamine. CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow eros...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Li C,Li C,Liu Z,Li Q,Yan X,Liu Y,Lu W

    更新日期:2014-10-20 00:00:00

  • Understanding the structure and stability of paclitaxel nanocrystals.

    abstract::Previously, PTX/Pluronic F127 nanocrystals were prepared in our laboratory using the stabilization of nanocrystals (SNC) method. For PTX nanocrystals, dosages could be increased to yield improved antitumor activity over Taxol without incidence of acute toxicity. The objectives of this current study are to further unde...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Deng J,Huang L,Liu F

    更新日期:2010-05-10 00:00:00

  • Continuous direct compression as manufacturing platform for sustained release tablets.

    abstract::This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected. Two HPMC grades were evaluated as matrix former: standard Methocel CR and direc...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Van Snick B,Holman J,Cunningham C,Kumar A,Vercruysse J,De Beer T,Remon JP,Vervaet C

    更新日期:2017-03-15 00:00:00

  • Cell uptake, cytoplasmic diffusion and nuclear access of a 6.5 nm diameter dendrimer.

    abstract::Macromolecular crowding and the presence of organelles in the cytosol present barriers to particle mobility, such that it is unclear how nano-carriers can deliver their active agents to the nucleus. In this work a sixth generation amino terminated polyamide polylysine dendrimer (Gly-Lys(63) (NH(2))(64)) (MW 8149, diam...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Ruenraroengsak P,Al-Jamal KT,Hartell N,Braeckmans K,De Smedt SC,Florence AT

    更新日期:2007-03-01 00:00:00

  • Cinnamate of inulin as a vehicle for delivery of colonic drugs.

    abstract::Colon diseases are difficult to treat because oral administrated drugs are absorbed at the stomach and intestine levels and they do not reach colon; in addition, intravenous administrated drugs are eliminated from the body before reaching colon. Inulin is a naturally occurring polysaccharide found in many plants. It c...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: López-Molina D,Chazarra S,How CW,Pruidze N,Navarro-Perán E,García-Cánovas F,García-Ruiz PA,Rojas-Melgarejo F,Rodríguez-López JN

    更新日期:2015-02-01 00:00:00

  • Influence of dissolution medium buffer composition on ketoprofen release from ER products and in vitro-in vivo correlation.

    abstract::The purpose of this work was to investigate the influence of dissolution medium composition on the in vitro release of ketoprofen from a series of ER products and the impact of the different buffer media on the in vivo-in vitro (IVIV) relationship. The products investigated were coated micro bead preparations having i...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Corrigan OI,Devlin Y,Butler J

    更新日期:2003-03-26 00:00:00

  • Nutlin-3 loaded nanocarriers: Preparation, characterization and in vitro antineoplastic effect against primary effusion lymphoma.

    abstract::In this investigation, Nutlin-3 (Nut3), a novel antitumor drug with low water solubility (<0.1mg/L at 25°C), was loaded into liposomes (Lipo-Nut3), polymeric nanoparticles (NPs-Nut3) and nanoparticles engineered with an antibody direct against Syndecan-1/CD 138 (Syn-NPs-Nut3) to obtain carriers targeted to PEL (primar...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Belletti D,Tosi G,Riva G,Lagreca I,Galliania M,Luppi M,Vandelli MA,Forni F,Ruozi B

    更新日期:2015-07-25 00:00:00

  • Aptamers as the chaperones (Aptachaperones) of drugs-from siRNAs to DNA nanorobots.

    abstract::Aptamers, nucleic acid ligands that are specific against their corresponding targets are increasingly employed in a variety of applications including diagnostics and therapeutics. The specificity of the aptamers against their targets is also used as the basis for the formulation of the aptamer-based drug delivery syst...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Citartan M,Kaur H,Presela R,Tang TH

    更新日期:2019-08-15 00:00:00