Abstract：
:This review aims to evaluate the evidence for the existence of a direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity and transported via the olfactory epithelium and/or via the trigeminal nerves directly to the CNS. This is relevant in the field of drug delivery as well as for new developments in nanotechnology. Experiments in animal models have shown that nano-sized drug delivery systems can enhance nose-to-brain delivery of drugs compared to equivalent drug solutions formulations. Protection of the drug from degradation and/or efflux back into the nasal cavity may partly be the reason for this effect of nanoparticles. It is uncertain, however, whether drug from the nanoparticles is being released in the nasal cavity or the nanoparticles carrying the drug are transported via the olfactory system or the trigeminal nerves into the CNS where the drug is released. Furthermore, toxicity of nanoparticulate drug delivery systems in the nasal cavity and/or in the CNS has not been extensively studied and needs to be considered carefully.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Mistry A,Stolnik S,Illum Ldoi
10.1016/j.ijpharm.2009.06.019subject
Has Abstractpub_date
2009-09-08 00:00:00pages
146-57issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(09)00412-8journal_volume
379pub_type
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journal_title：International journal of pharmaceutics
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更新日期：2002-02-21 00:00:00
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pub_type： 杂志文章
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更新日期：2007-06-29 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.ijpharm.2013.12.051
更新日期：2014-04-10 00:00:00
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更新日期：2014-07-01 00:00:00
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更新日期：2020-02-15 00:00:00
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更新日期：2015-05-15 00:00:00
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更新日期：2014-07-01 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of pharmaceutics
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更新日期：2007-09-05 00:00:00
