Abstract:
:The potential of two derivatives of vitamin E, i.e. α-tocopheryl phosphate (TP) and di-α-tocopheryl phosphate (T2P), for the protection and delivery of therapeutics is being investigated in our laboratory and some promising results have been obtained so far. Novel nanocarrier systems containing TP, T2P and different lipids/phospholipids (phosphatidylcholine, stearyl amine, Phospholipon 90H, Phospholipon 100H) with and without cholesterol were prepared using Mozafari method. The preparation method did not require utilization of potentially toxic solvents, detergents or employment of harsh treatments such as sonication or high-shear force homogenization. Tocosomes, containing 5-fluorouracil (as a model drug), were shown to possess narrow size distribution, acceptable encapsulation efficiency and long-term stability (more than two years).
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Mozafari MR,Javanmard R,Raji Mdoi
10.1016/j.ijpharm.2017.06.037subject
Has Abstractpub_date
2017-08-07 00:00:00pages
381-382issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30545-8journal_volume
528pub_type
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